Osteoclast precursors circulate in avian blood

1992 ◽  
Vol 51 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Jose. I. Alvarez ◽  
F. Patrick Ross ◽  
Nicholas A. Athanasou ◽  
Harry C. Blair ◽  
Edward M. Greenfield ◽  
...  
Keyword(s):  
Osteoclast Precursors ◽  
Avian Blood

scholarly journals Biological Effects of β-Glucans on Osteoclastogenesis

Molecules ◽  
2021 ◽  
Vol 26 (7) ◽  
pp. 1982
Author(s):  
Wataru Ariyoshi ◽  
Shiika Hara ◽  
Ayaka Koga ◽  
Yoshie Nagai-Yoshioka ◽  
Ryota Yamasaki
Keyword(s):  
Bone Resorption ◽  
Bone Marrow Cells ◽  
Biological Effects ◽  
Osteoclast Differentiation ◽  
Treatment Strategies ◽  
Alcaligenes Faecalis ◽  
Osteoclast Formation ◽  
Osteoclast Precursors

Although the anti-tumor and anti-infective properties of β-glucans have been well-discussed, their role in bone metabolism has not been reviewed so far. This review discusses the biological effects of β-glucans on bone metabolisms, especially on bone-resorbing osteoclasts, which are differentiated from hematopoietic precursors. Multiple immunoreceptors that can recognize β-glucans were reported to be expressed in osteoclast precursors. Coordinated co-stimulatory signals mediated by these immunoreceptors are important for the regulation of osteoclastogenesis and bone remodeling. Curdlan from the bacterium Alcaligenes faecalis negatively regulates osteoclast differentiation in vitro by affecting both the osteoclast precursors and osteoclast-supporting cells. We also showed that laminarin, lichenan, and glucan from baker’s yeast, as well as β-1,3-glucan from Euglema gracilisas, inhibit the osteoclast formation in bone marrow cells. Consistent with these findings, systemic and local administration of β-glucan derived from Aureobasidium pullulans and Saccharomyces cerevisiae suppressed bone resorption in vivo. However, zymosan derived from S. cerevisiae stimulated the bone resorption activity and is widely used to induce arthritis in animal models. Additional research concerning the relationship between the molecular structure of β-glucan and its effect on osteoclastic bone resorption will be beneficial for the development of novel treatment strategies for bone-related diseases.

scholarly journals SAT0161 Menatetrenone acts directly on circulating human osteoclast precursors

2001 ◽  
Author(s):  
T Hirayama ◽  
H Taira ◽  
O Kudo ◽  
I Itonaga ◽  
T Torisu ◽  
...  
Keyword(s):  
Osteoclast Precursors ◽  
Human Osteoclast

The Effect of Poly( d , l -Lactide-co-Glycolide)-Alendronate Conjugate Nanoparticles on Human Osteoclast Precursors

2012 ◽  
Vol 23 (10) ◽  
pp. 1285-1300 ◽  
Author(s):  
Elisabetta Cenni ◽  
Sofia Avnet ◽  
Donatella Granchi ◽  
Caterina Fotia ◽  
Manuela Salerno ◽  
...  
Keyword(s):  
Osteoclast Precursors ◽  
Human Osteoclast

scholarly journals The Integrin αvβ5 Is Expressed on Avian Osteoclast Precursors and Regulated by Retinoic Acid

1999 ◽  
Vol 14 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Karen Sago ◽  
Steven L. Teitelbaum ◽  
Kristy Venstrom ◽  
Louis F. Reichardt ◽  
F. Patrick Ross
Keyword(s):  
Retinoic Acid ◽  
Osteoclast Precursors
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