Renal handling of cadmium and cadmium-metallothionein: studies on the isolated perfused rat kidney

1987 ◽  
Vol 60 (5) ◽  
pp. 370-375 ◽  
Author(s):  
J. Abel ◽  
D. H�hr ◽  
H. -J. Schurek
Keyword(s):  
Rat Kidney ◽  
Renal Handling ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Renal handling and effects of indomethacin in the isolated perfused rat kidney

1990 ◽  
Vol 183 (6) ◽  
pp. 2077
Author(s):  
P.G.F. Cox ◽  
M.M. Moons ◽  
F.G.M. Russel ◽  
C.A.M. van Ginneken
Keyword(s):  
Rat Kidney ◽  
Renal Handling ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Tubular reabsorption rates for myoglobin in the isolated perfused rat kidney

1986 ◽  
Vol 70 (6) ◽  
pp. 595-599 ◽  
Author(s):  
P. J. Ratcliffe ◽  
M. P. Esnouf ◽  
J. G. G. Ledingham
Keyword(s):  
Rat Kidney ◽  
Tubular Reabsorption ◽  
Renal Tubules ◽  
Immunoglobulin Light Chain ◽  
Renal Handling ◽  
Water Excretion ◽  
Isolated Perfused Rat Kidney ◽  
Saturation Kinetics ◽  
Perfused Rat Kidney ◽  
Kinetics Of

1. The renal handling of myoglobin has been studied in the isolated perfused rat kidney. 2. Myoglobin was freely filtered. Reabsorption by the renal tubules showed saturation kinetics with a relatively low maximum rate of reabsorption (Tmax) of 27-30 μg min−1 g−1 wet wt. at a perfusate concentration of 70-80 μg/ml. Myoglobin reabsorption is therefore much less than that reported for immunoglobulin light chain or lysozyme in this model. 3. Large increases in sodium and water excretion produced by omission of oncotic agent from the perfusate did not alter the kinetics of myoglobin reabsorption. 4. The use of bovine serum albumin as oncotic agent in the perfusate prevented the tubular reabsorption of myoglobin. Small amounts of albumin are filtered by the isolated perfused kidney and it is postulated that this albumin interferes with tubular reabsorption of myoglobin.

Renal Handling of Tobramycin in the Isolated Perfused Rat Kidney

1994 ◽  
Vol 83 (5) ◽  
pp. 723-726 ◽  
Author(s):  
Tetsuya Aiba ◽  
Yoshie Itoga ◽  
Hiromasa Shimizu ◽  
Yusuke Tanigawara ◽  
Ryohei Hori
Keyword(s):  
Rat Kidney ◽  
Renal Handling ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney

Indometacin: Renal Handling and Effects in the Isolated Perfused Rat Kidney

Pharmacology ◽  
1991 ◽  
Vol 42 (5) ◽  
pp. 287-296 ◽  
Author(s):  
Peter G.F. Cox ◽  
Miek M. Moons ◽  
Frans G.M. Russel ◽  
Cees A.M. van Ginneken
Keyword(s):  
Rat Kidney ◽  
Renal Handling ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney
Sign in / Sign up

Export Citation Format

Share Document