Correlation between 1.25 dihydroxyvitamin D serum levels and fractional rate of intestinal calcium absorption in hypercalciuric nephrolithiasis. role of phosphate

1992 ◽  
Vol 20 (1) ◽  
pp. 96-97
Author(s):  
M. V. Alvarez-Arroyo ◽  
M. L. Traba ◽  
A. Rapado ◽  
C. de la Piedra ◽  
M. Torralbo
Keyword(s):  
Calcium Absorption ◽  
Serum Levels ◽  
Intestinal Calcium Absorption ◽  
Dihydroxyvitamin D ◽  
Fractional Rate

Role of prolactin in vitamin D metabolism and calcium absorption during lactation in the rat

1982 ◽  
Vol 94 (3) ◽  
pp. 443-453 ◽  
Author(s):  
C. J. Robinson ◽  
E. Spanos ◽  
M. F. James ◽  
J. W. Pike ◽  
M. R. Haussler ◽  
...  
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Parathyroid Hormone ◽  
Alkaline Phosphatase Activity ◽  
Plasma Levels ◽  
Calcium Absorption ◽  
High Plasma ◽  
Intestinal Calcium Absorption ◽  
Vitamin D Metabolism

Intestinal calcium absorption and plasma levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) were measured in lactating and non-lactating rats and the effects of bromocriptine and exogenous prolactin treatment were evaluated. In lactating rats calcium absorption and plasma levels of parathyroid hormone, 1,25(OH)2D3 and alkaline phosphatase activity were significantly increased. Bromocriptine treatment significantly reduced the enhanced calcium absorption and levels of plasma 1,25(OH)2D3 and alkaline phosphatase but had no significant effect on plasma levels of parathyroid hormone. Prolactin administered with bromocriptine to lactating animals prevented all the changes observed with bromocriptine treatment alone. It was concluded that the increased plasma levels of prolactin during lactation lead to high plasma levels of 1,25(OH)2D3 which are responsible for the enhanced intestinal calcium absorption.

scholarly journals Increased Circulatory Level of Biologically Active Full-Length FGF-23 in Patients with Hypophosphatemic Rickets/Osteomalacia

2002 ◽  
Vol 87 (11) ◽  
pp. 4957-4960 ◽  
Author(s):  
Yuji Yamazaki ◽  
Ryo Okazaki ◽  
Minako Shibata ◽  
Yukihiro Hasegawa ◽  
Kohei Satoh ◽  
...  
Keyword(s):  
Sandwich Elisa ◽  
Elevated Serum ◽  
Serum Levels ◽  
Biologically Active ◽  
Hypophosphatemic Rickets ◽  
Dihydroxyvitamin D ◽  
Autosomal Dominant Hypophosphatemic Rickets ◽  
Circulatory Level ◽  
Fgf 23

Abstract Hypophosphatemic rickets/osteomalacia with inappropriately low serum 1,25-dihidroxyvitamin D level is commonly observed in X-linked hypophosphatemic rickets/osteomalacia, autosomal dominant hypophosphatemic rickets/osteomalacia and tumor-induced osteomalacia. Although the involvement of a newly identified factor, FGF-23, in the pathogenesis of ADHR and TIO has been suggested, clinical evidence indicating the role of FGF-23 has been lacking. We have previously shown that FGF-23 is cleaved between Arg179 and Ser180, and this processing abolished biological activity of FGF-23 to induce hypophosphatemia. Therefore, sandwich ELISA for biologically active intact human FGF-23 was developed using two kinds of monoclonal antibodies that requires the simultaneous presence of both the N-terminal and C-terminal portion of FGF-23. The serum levels of FGF-23 in healthy adults were measurable and ranged from 8.2 to 54.3 ng/L. In contrast, those in a patient with TIO were over 200 ng/L. After the resection of the responsible tumor, the elevated FGF-23 level returned to normal level within 1 h. The increase of serum concentrations of 1,25-dihidroxyvitamin D and phosphate, and the decrease of serum 24,25-dihydroxyvitamin D followed the change of FGF-23. In addition, the elevated serum FGF-23 levels were demonstrated in most patients with XLH. It is likely that increased serum levels of FGF-23 contributes to the development of hypophosphatemia not only in TIO but also in XLH.

THE ROLE OF THE THYROID IN THE INTESTINAL EFFECT OF VITAMIN D ON RACHITIC RATS

1970 ◽  
Vol 48 (4) ◽  
pp. 541-544 ◽  
Author(s):  
M. WINTER ◽  
E. MORAVA ◽  
G. SIMON
Keyword(s):  
Vitamin D ◽  
Intestinal Absorption ◽  
Calcium Absorption ◽  
Intestinal Calcium Absorption ◽  
Thyroid Glands ◽  
And Control

SUMMARY The effect of 20 i.u. vitamin D3 on the intestinal absorption of calcium was investigated in thyroidectomized and control rachitic rats. Vitamin D3 increased both duodenal and jejunal calcium absorption in the absence of the thyroid glands. These results suggest that neither thyroxine nor calcitonin are necessary for the effect of vitamin D3 on intestinal calcium absorption.

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