The synaptonemal complexes of Caenorhabditis elegans

Chromosoma ◽  
1982 ◽  
Vol 84 (4) ◽  
pp. 585-597 ◽  
Author(s):  
Paul Goldstein ◽  
Darlina E. Slaton
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptonemal Complexes

scholarly journals Exposure to the anthelmintic dinitroaniline oryzalin causes changes in meiotic prophase morphology and loss of synaptonemal complexes in the nematode Caenorhabditis elegans

2021 ◽  
Vol 2 ◽  
Author(s):  
Paul Goldstein
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Matrix ◽  
Meiotic Prophase ◽  
Parasitic Nematodes ◽  
Nematode Caenorhabditis Elegans ◽  
Synaptonemal Complexes ◽  
Prophase I ◽  
Meiotic Prophase I

Abstract The anthelmintic dinitroaniline oryzalin interferes with the formation of microtubules and inhibits meiosis and mitosis in nematodes. Exposure to oryzalin resulted in deterioration in morphology of the oocytes and loss of synaptonemal complexes at meiotic prophase I. The nuclear matrix and envelope were poorly formed, and the central rachis was diminished. These results provide the basis for the loss of fecundity after treatment with the oryzalin resulting in control of parasitic nematodes.

Triplo-X hermaphrodite of Caenorhabditis elegans: pachytene karyotype analysis, synaptonemal complexes, and pairing mechanisms

1984 ◽  
Vol 26 (1) ◽  
pp. 13-17 ◽  
Author(s):  
Paul Goldstein
Keyword(s):  
Caenorhabditis Elegans ◽  
Karyotype Analysis ◽  
Real Difference ◽  
X Chromosomes ◽  
Synaptonemal Complexes ◽  
Chromosomal Complement ◽  
Male Line ◽  
Pachytene Karyotype

Pairing of the three X chromosomes in the triplo-X strain of Caenorhabditis elegans occurs at pachytene in a two-by-two fashion such that one bivalent and one univalent are formed. The XX bivalent pairs synchronously with the autosomes and the univalent X remains in a similar chromatic state as the rest of the chromosomal complement. Normal tripartite synaptonemal complexes (SC) are formed between all bivalents. The univalent X lacks a SC and an axial core is not observed. The condensation of the univalent X in the triplo-X is different than in the male where the univalent X is heterochromatic. This real difference in condensation states of the chromatin may explain the fact that the univalent X is maintained in the male line yet it is easily lost in the triplo-X strain.

The synaptonemal complexes of Caenorhabditis elegans: duplication mutants sDp1 and mnDp1, disjunction regulator regions and aneuploidy

Nematology ◽  
2010 ◽  
Vol 12 (5) ◽  
pp. 759-766
Author(s):  
Paul Goldstein
Keyword(s):  
Caenorhabditis Elegans ◽  
Linkage Group ◽  
X Chromosome ◽  
Initiation Site ◽  
Genetic Maps ◽  
Wild Type ◽  
Pachytene Nucleus ◽  
Synaptonemal Complexes ◽  
Recombination Nodules ◽  
Group I

AbstractThe duplication mutants sDp1 and mnDp1 in Caenorhabditis elegans differ in their size and recombination/pairing strategies within the pachytene nucleus. mnDp1 is a duplication of approximately 18% of the X chromosome with the duplicated segment transposed and inserted into linkage group V. sDp1 is a free duplication which covers 30 map units of linkage group I and crossing-over has been determined genetically with its homologue. Analysis of the synaptonemal complexes (SC) and pachytene karyotypes of both duplication mutants reveal that there is an extension of one of the SCs in mnDp1 while the sDp1 free duplication partially pairs with its homologue along a small portion of its length. The remaining region exists as a univalent in the pachytene nucleus. This indicates that there is at least one SC initiation site on the sDp1 free duplication. Only bivalent pairing is permitted and there are no trivalents. To some extent, the autosomes preferentially pair at the exclusion of the sDp1 duplication. Switching of pairing partners was evident between the duplication and the homologue, probably because of the size of the duplication. Thus, the mechanism of chromosome segregation in the two duplications is different. The number of Disjunction Regulator Regions, which are associated with X-chromosome nondisjunction, was three in both mutants compared to six in wild-type. The number of males produced in mnDp1 was 1.0%, in sDp1 it was 2.0%, while in wild-type it is 0.3%. Recombination nodules were not observed in any nuclei. The ultimate goal of these studies is to correlate the physical and genetic maps and in this study linkage group I has been identified in the pachytene nucleus.

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