Unusual response to bifunctional alkylating agents in a case of Fanconi anaemia

1983 ◽  
Vol 64 (4) ◽  
pp. 384-387 ◽  
Author(s):  
M. L. Kwee ◽  
E. H. A. Poll ◽  
J. J. P. van de Kamp ◽  
H. de Koning ◽  
A. W. Eriksson ◽  
...  
Keyword(s):  
Alkylating Agents ◽  
Fanconi Anaemia

Fanconi anaemia group A (FANCA) mutations in Israeli non-Ashkenazi Jewish patients

2000 ◽  
Vol 111 (1) ◽  
pp. 338-343 ◽  
Author(s):  
H. Tamary ◽  
R. Bar-Yam ◽  
L. Shalmon ◽  
G. Rachavi ◽  
M. Krostichevsky ◽  
...  
Keyword(s):  
Fanconi Anaemia ◽  
Ashkenazi Jewish ◽  
Group A

Photocatalytic Alkylation of Pyrroles and Indoles with α-Diazo Esters

2019 ◽  
Author(s):  
Łukasz Ciszewski ◽  
Jakub Durka ◽  
Dorota Gryko
Keyword(s):  
Aromatic Compounds ◽  
Reaction Pathway ◽  
Alkylating Agents ◽  
Catalytic Amount ◽  
Radical Formation ◽  
Reaction Selectivity ◽  
Diazo Esters ◽  
Electron Withdrawing Substituents

This article describes direct photoalkylation of electron-rich aromatic compounds with diazo compoiunds. C-2 alkylated indoles and pyrroles are obtained with good yields even though the photocatalyst (Ru(bpy)3Cl2) loading is as low as 0.075 mol %. For substrates bearing electron-withdrawing substituents the addition of a catalytic amount of N,N-dimethyl-4-methoxyaniline is required. Both EWG-EWG and EWG-EDG substituted diazo esters are suitable as alkylating agents. The reaction selectivity and mechanistic experiments suggest that carbenes/carbenoid intermediates are not involved in the reaction pathway, instead radical formation is proposed.

Hydrogeochemistry of Toxic Elements in Urbanized Geotechnical Systems

1997 ◽  
Vol 32 (3) ◽  
pp. 523-550
Author(s):  
S.N. Volkov
Keyword(s):  
Heavy Metals ◽  
Toxic Elements ◽  
Life Support ◽  
Alkylating Agents ◽  
Pollution Sources ◽  
The Urals

Abstract In urbanized geotechnical systems (UGSs), the majority of problems related to the ecological hydrochemistry of Cd, Pb, Ni and other heavy metals are the result of emergent characteristics of a system as a whole as opposed to individual pollution sources. In petrochemical UGSs, pollution of the environment from compounds containing methylating or alkylating agents results in an increase in the mobility of Cd, Pb, Ni, Cr and As. This process is controlled by environmental and microclimatic factors rather than by pollution sources. Under conditions of predominant dust and element effects, geo-chemically paradoxical associations of Cd with Ni, Mn and Cr can be formed in the main life support media in mining and metallurgical UGSs. Uncontrolled processes of hydrochemical interactions take place in complex multifunctional UGSs, leading to a change in speciation of heavy metals, particularly cadmium. This report is part of a 5-year study of the geotechnical systems in the Urals.

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