A physical map of the apolipoprotein gene cluster on human chromosome 19

1988 ◽  
Vol 78 (3) ◽  
pp. 244-247 ◽  
Author(s):  
Ola Myklebost ◽  
Sissel Rogne
Keyword(s):  
Human Chromosome ◽  
Gene Cluster ◽  
Physical Map ◽  
Chromosome 19 ◽  
Human Chromosome 19

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19

1995 ◽  
Vol 41 (6) ◽  
Author(s):  
S.M.G. Hoffman ◽  
P. Fernandez-Salguero ◽  
F.J. Gonzalez ◽  
H.W. Mohrenweiser
Keyword(s):  
Cytochrome P450 ◽  
Human Chromosome ◽  
Gene Cluster ◽  
Chromosome 19 ◽  
Human Chromosome 19

Organization, structure and evolution of the CYP2 gene cluster on human chromosome 19

2001 ◽  
Vol 11 (8) ◽  
pp. 687-698 ◽  
Author(s):  
Susan M. G. Hoffman ◽  
David R. Nelson ◽  
Diane S. Keeney
Keyword(s):  
Human Chromosome ◽  
Gene Cluster ◽  
Organization Structure ◽  
Chromosome 19 ◽  
Human Chromosome 19

An integrated metric physical map of human chromosome 19

1995 ◽  
Vol 11 (4) ◽  
pp. 422-427 ◽  
Author(s):  
Linda K. Ashworth ◽  
Mark A. Batzer ◽  
Brigitte Brandriff ◽  
Elbert Branscomb ◽  
Pieter de Jong ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Physical Map ◽  
Chromosome 19 ◽  
Human Chromosome 19

The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19

1984 ◽  
Vol 67 (2) ◽  
pp. 174-177 ◽  
Author(s):  
C. Julier ◽  
D. Weil ◽  
P. Couillin ◽  
J. C. Côté ◽  
Cong Van Nguyen ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Gene Cluster ◽  
Chorionic Gonadotropin ◽  
Chromosome 19 ◽  
Human Chromosome 19

A Continuous High-Resolution Physical Map Spanning 17 Megabases of the q12, q13.1, and q13.2 Cytogenetic Bands of Human Chromosome 19

Genomics ◽  
1995 ◽  
Vol 27 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Emilio Garcia ◽  
Jeffrey Elliott ◽  
Ann Gorvad ◽  
Brigitte Brandriff ◽  
Laurie Gordon ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Chromosome ◽  
Physical Map ◽  
Chromosome 19 ◽  
Human Chromosome 19

A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein

2002 ◽  
Vol 296 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Chiang Wang ◽  
Ida M McCarty ◽  
Louisa Balazs ◽  
Yi Li ◽  
Mitchell S Steiner
Keyword(s):  
Human Chromosome ◽  
Chromosome 19 ◽  
Human Chromosome 19 ◽  
Novel Protein

scholarly journals The Genomic Geography and Evolution of Clusters of Tandemly Duplicated Genes in the Human and Mammal Genomes

2018 ◽  
Author(s):  
Juan F Ortiz ◽  
Antonis Rokas
Keyword(s):  
Human Chromosome ◽  
Olfactory Receptors ◽  
Gene Families ◽  
Pathogen Resistance ◽  
Duplicated Genes ◽  
Chromosome 19 ◽  
Fusion Event ◽  
Origin And Evolution ◽  
Mammalian Genomes ◽  
Human Chromosome 19

Clusters of duplicated genes (CTDGs) are nearly ubiquitous in life's genomes, and are associated with several well-known gene families, such as olfactory receptors, zinc fingers, and immunity-related genes, as well as with several highly variable traits, including olfaction, body plan architecture, and pathogen resistance. However, these observations are usually anecdotal, restricted to specific cases, and lacking evolutionary context. In this study, we use a robust statistical approach to characterize the CTDG repertoire and analyze the distribution of CTDGs across 18 mammal genomes, including human. We found that, on average, 18% of the genes in each species are parts of CTDGs. Although genes in CTDGs are enriched for several biological processes, these tend to be involved in the interactions between the organism and its environment. We further found that mammalian CTDGs are not uniformly distributed across chromosomes and that orthologs of the human chromosome 19 are among the most clustered chromosomes in nearly all mammalian genomes analyzed. We also found evidence that the human chromosome 19 was formed by a fusion event that occurred before the diversification of the rodent and primate lineages and maintained its high density of CTDGs during its subsequent evolution. Finally, using chromosome-level alignments across mammalian genomes, we show how the syntenic regions of the human chromosome 19 have been shrinking, increasing their gene density and possibly increasing the compactness of its CTDGs. These results suggest that CTDGs are a major feature of mammalian genomes and provide novel insights into the origin and evolution of regions with unusually high densities of CTDGs.

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