Effect of aminoglycoside antibiotics on the autolytic enzyme of Streptomyces griseus

1990 ◽  
Vol 155 (1) ◽  
pp. 99-102 ◽  
Author(s):  
Istv�n Szab� ◽  
Andr�s Penyige ◽  
Gy�rgy Barab�s ◽  
Judit Barab�s
Keyword(s):  
Streptomyces Griseus ◽  
Aminoglycoside Antibiotics ◽  
Autolytic Enzyme

scholarly journals Study on Streptomycin Level in Raw Milk

2011 ◽  
Vol 68 (2) ◽  
Author(s):  
Dorin TIBULCA ◽  
Mirela JIMBOREAN ◽  
Claudiu Dan SALAGEAN
Keyword(s):  
Antibiotic Resistance ◽  
Side Effects ◽  
Streptomyces Griseus ◽  
Raw Milk ◽  
Aminoglycoside Antibiotics ◽  
Three Components

Streptomycin consists of three components, which are linked together by glycoside bonds, and it belongs to the group of the aminoglycoside antibiotics. Streptomycin is naturally produced by actinobacterium Streptomyces griseus. Therapeutically it is used in the case of streptococcal and enterococcal enteritis. Because of its side effects it is rarely used in human treatment, but has an application in the veterinary area. After the treatment of mastitis in breeding animals, increased values of streptomycin were also recorded in liver, kidney, muscle and milk. Presence of Streptomycins in milk has hygienic and industrial implications. Concerning the industrial aspect the Streptomycin residues are inhibitors for proliferation of the lactic microflora. In terms of hygiene, streptomycin can induce the antibiotic resistance phenomenon

An enzymatic release of antibiotic-containing peptidoglycan fragments from streptomycin-producing Streptomyces griseus

1980 ◽  
Vol 26 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Gy. Barabás ◽  
I. Szabó ◽  
A. Ottenberger ◽  
V. Zs.-Nagy ◽  
G. Szabó
Keyword(s):  
Amino Acids ◽  
Cell Wall ◽  
Glutamic Acid ◽  
Streptomyces Griseus ◽  
Activity Analysis ◽  
Antibiotic Activity ◽  
Diaminopimelic Acid ◽  
Autolytic Enzyme ◽  
A Cell

A cell wall bound autolytic enzyme of a streptomycin-producing strain of Streptomyces griseus was investigated. The peptidoglycan fragments released by the enzyme showed antibiotic activity. Analysis of these fragments proved that streptomycin is bound to a cell wall peptide. The peptide contained the four amino acids characteristic of Streptomyces cell wall: alanine, glycine, diaminopimelic acid, and glutamine or glutamic acid.

Nomenclature Abstract for Streptomyces griseus alpha (Ciferri 1927) Pridham 1970 (Approved Lists 1980).

2003 ◽  
Author(s):  
Charles Thomas Parker ◽  
Nicole Danielle Osier ◽  
George M Garrity ◽  
Dorothea Taylor
Keyword(s):  
Streptomyces Griseus

The Development of a Turbidimetric Method for the Quantitative Determination of Antibiotics of the Aminoglycoside Group in Medications

2020 ◽  
Vol 65 (7-8) ◽  
pp. 37-41
Author(s):  
E. N. Semenova ◽  
S. I. Kuleshova ◽  
E. I. Sakanyan
Keyword(s):  
Quantitative Determination ◽  
Quality Assessment ◽  
Aminoglycoside Antibiotics ◽  
Metrological Characteristics ◽  
Streptomycin Sulfate ◽  
Turbidimetric Method ◽  
Validation Criteria ◽  
Validation Parameters ◽  
Validation Tests

A method for the quantitative determination of streptomycin sulfate in medicines by the turbidimetric method has been developedand validated. Based on the results of the experiments, it was found that the metrological characteristics of such validation parameters of the method as linearity, precision, and correctness do not exceed the validation criteria. Linearity was noted in the range of streptomycin concentrations from 3.75 to 8.43 μg/ml. The results of validation tests of the method for the quantitative determination of streptomycin indicate the prospects and feasibility of introducing the turbidimetric method into the domestic system for standardization and quality assessment of aminoglycoside antibiotics.

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