Development of meningeal leukemia in rats by intracerebral or intrameningeal inoculation of the acute transplantable leukemia L 5222

1976 ◽  
Vol 86 (3) ◽  
pp. 287-292 ◽  
Author(s):  
H. H. Fiebig ◽  
W. J. Zeller ◽  
D. Schm�hl
Keyword(s):  
Transplantable Leukemia ◽  
Leukemia L 5222 ◽  
Meningeal Leukemia

Meningeal Leukemia following Lymphoid Blast Crisis in Chronic Myeloid Leukemia: Therapeutic Implications

1982 ◽  
Vol 68 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Mario Cazzola ◽  
Giulio Nalli ◽  
Ercole Brusamolino ◽  
Maurizio Daccò ◽  
Angela Ghizzi ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Chronic Myeloid Leukemia ◽  
Complete Remission ◽  
Myeloid Leukemia ◽  
Lymphoblastic Leukemia ◽  
Blast Crisis ◽  
Early Prevention ◽  
Therapeutic Implications ◽  
Therapeutic Protocol ◽  
Meningeal Leukemia

Five of 40 patients with chronic myeloid leukemia (CML) had lymphoid blast crisis and 4 of them achieved complete remission of metamorphosis with vincristine and prednisone. While in hematologic remission, two of these subjects developed meningeal leukemia. Clinical and biologic data indicated that the course of the disease after lymphoid blast crisis was very similar to that of acute lymphoblastic leukemia (ALL). It is suggested that patients with CML who develop lymphoid blast crisis should be treated with an intensive therapeutic protocol including early prevention of meningeal leukemia.

scholarly journals Development of meningeal leukemia (L1210) during treatment of subcutaneously inoculated mice with methotrexate

Cancer ◽  
1964 ◽  
Vol 17 (3) ◽  
pp. 352-360 ◽  
Author(s):  
Louis B. Thomas ◽  
Michael A. Chirigos ◽  
Stewart R. Humphreys ◽  
Abraham Goldin
Keyword(s):  
Meningeal Leukemia

An animal model for meningeal leukemia

1974 ◽  
Vol 13 (6) ◽  
pp. 863-866 ◽  
Author(s):  
K. Perk ◽  
J. W. Pearson ◽  
J. A. Torgersen ◽  
M. A. Chirigos
Keyword(s):  
Animal Model ◽  
Meningeal Leukemia

Prophylaxis and “Total Therapy” of Meningeal Leukemia

1972 ◽  
pp. 109-122 ◽  
Author(s):  
Lawrence E. Broder ◽  
Stephen K. Carter
Keyword(s):  
Total Therapy ◽  
Meningeal Leukemia

Combination Radiotherapy and Chemotherapy in Meningeal Leukemia

1972 ◽  
pp. 87-88
Author(s):  
Lawrence E. Broder ◽  
Stephen K. Carter
Keyword(s):  
Meningeal Leukemia

scholarly journals Proliferative kinetics of the leukemic cells in meningeal leukemia

Cancer ◽  
1978 ◽  
Vol 42 (3) ◽  
pp. 1255-1262 ◽  
Author(s):  
Jun Tsuchiya ◽  
Masaki Moteki ◽  
Shunichi Shimano ◽  
Shogo Shinonome ◽  
Tetsuo Suda ◽  
...  
Keyword(s):  
Leukemic Cells ◽  
Kinetics Of ◽  
Meningeal Leukemia

scholarly journals Particulate Component in the Blood Plasma of Mice with Transplantable Leukemia

Blood ◽  
1955 ◽  
Vol 10 (4) ◽  
pp. 325-333 ◽  
Author(s):  
E. DE ROBERTIS ◽  
R. CANZANI ◽  
G. GASIC ◽  
B. EPSTEIN
Keyword(s):  
Particle Size ◽  
Electron Microscope ◽  
Blood Plasma ◽  
Survival Time ◽  
Red Cell ◽  
Mouse Leukemia ◽  
Probable Significance ◽  
Transplantable Leukemia ◽  
Large Peak ◽  
Red Cell Membranes

Abstract Blood and plasma smears of mice inoculated with two leukemic lines were studied under the electron microscope. In 15 mice of the AKR strain and in two C58 mice inoculated with the Hch leukemia line of the Instituto de Biología of Chile (372 to 382 transfers), dense submicroscopic particles were found in the blood plasma. In some cases isolated particles or clumps of them were found adsorbed on the red cell membranes. The particle size ranged between 19 and 58 mµ, with a large peak at 38 mµ. The survival time of the inoculated animals was of 5 days and the submicroscopic particles were constantly found between the 3rd and 5th day. Similar dense submicroscopic particles were found in blood plasma smears of three C58 mice at the 16th day after inoculation with the Ich leukemia line (86th transfer). The probable significance of these particles is discussed on the basis of the literature regarding the etiology of mouse leukemia.

scholarly journals The Effect of Endotoxin on Haemostasis in Normal and Leukemic Rats

1977 ◽  
Author(s):  
H. Rasche ◽  
D. Hoelzer
Keyword(s):  
Platelet Count ◽  
Early Phase ◽  
Elevated Level ◽  
Single Injection ◽  
Final Phase ◽  
Phase Group ◽  
Group A ◽  
Group B ◽  
Leukemia L 5222 ◽  
Normal Controls

Platelet count, fibrinogen and antithrombin levels were studied in normal rats (group A), in rats with the experimental rat leukemia L 5222 in an early phase (group B) and in a final phase (group C) of the disease. The animals were randomized and treated with o.5 mg endotoxin or placebo as a single i.v.injection. Four hours later blood samples were taken for laboratory tests. The results were as follows: 1. Groups A and B did not differ in the laboratory parameters under investigation 4 hours after injection of saline as a placebo. 2. Leukemic rats of group C treated with saline had significantly elevated levels of fibrinogen and antithromin as well as reduced platelet count compared to their normal counterparts. 3. The injection of endotoxin resulted in a comparable decrease of platelets in normal and leukemic animals. 4. The injection of endotoxin led to a decrease of fibrinogen levels in all groups. The most pronounced decrease was observed in group B, while there was only a slight fall in group C. The antithrombin levels of group A and B were not influenced by endotoxinaemia. The elevated level of antithrombin in group C, however, was completely normalized after a single injection of endotoxin.It can be concluded from these results that the haemostatic system of rats in the early phase of the leukemia L 5222 is more susceptible to endotoxin than that of normal controls. Possibly due to marked elevated levels of antithrombin rats in the final phase of the disease seem to be protected against the aggravation of the haemostatic defect by endotoxin.

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