T and B lymphocytes in Hodgkin's disease

1973 ◽  
Vol 80 (3) ◽  
Author(s):  
W.M. Gallmeier ◽  
Uta Bruntsch ◽  
R. Pfeiffer ◽  
Ulrike Bestek ◽  
C.G. Schmidt
Keyword(s):  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
T And B Lymphocytes

T AND B LYMPHOCYTES IN SPLEENS IN HODGKIN'S DISEASE

The Lancet ◽  
1975 ◽  
Vol 305 (7921) ◽  
pp. 1378-1379 ◽  
Author(s):  
D.J.Th Wagener ◽  
E Geestman ◽  
A Borgonjen
Keyword(s):  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
T And B Lymphocytes

scholarly journals Splenic T and B lymphocytes and their mitogenic response in untreated Hodgkin's disease

Cancer ◽  
1980 ◽  
Vol 45 (4) ◽  
pp. 767-774 ◽  
Author(s):  
Tin Han ◽  
Jun Minowada ◽  
Vadakkencheri Subramanian ◽  
Maurice Barcos ◽  
Untae Kim
Keyword(s):  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
T And B Lymphocytes ◽  
Mitogenic Response

T AND B LYMPHOCYTES IN SPLEEN IN HODGKIN'S DISEASE

The Lancet ◽  
1975 ◽  
Vol 305 (7909) ◽  
pp. 747-748 ◽  
Author(s):  
R.R Joseph ◽  
D Belpomme
Keyword(s):  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
T And B Lymphocytes

scholarly journals Epstein-Barr virus (EBV)-associated lymphoproliferations in severe combined immunodeficient mice transplanted with Hodgkin's disease lymph nodes: implications of EBV-positive bystander B lymphocytes rather than EBV-infected Reed-Sternberg cells

Blood ◽  
1996 ◽  
Vol 87 (6) ◽  
pp. 2435-2442 ◽  
Author(s):  
F Meggetto ◽  
C Muller ◽  
S Henry ◽  
J Selves ◽  
B Mariame ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Hodgkin’S Disease ◽  
Scid Mice ◽  
Barr Virus ◽  
Epstein Barr

To establish an in vivo model for the study of Hodgkin's disease and Reed-Sternberg (RS) cells, 25 lymph node tissue samples involved by Hodgkin's disease were grafted into severe combined immunodeficiency (SCID) mice. Ten Epstein-Barr virus (EBV)-associated tumors were obtained in SCID mice. EBV-positive tumors growing in SCID mice were correlated with the presence of EBV-positive nonneoplastic B cells in patient tumors (90% v 26.6%; P>.01) and was independent of the EBV status of RS cells. Our results suggested that EBV-positive tumors growing in SCID mice originated from normal EBV-positive small lymphocytes (bystander B lymphocytes). We also compared the characteristics of these tumors with those obtained after transplantation of 15 non-Hodgkin's lymphoma and four reactive lymph nodes. The latent period to observe a growing tumor in SCID mice was similar between the two groups (12.86 +/- 5.59 weeks for Hodgkin's disease v 13.6 +/- 5.36 weeks for non-Hodgkin's lymphoma and reactive lymph nodes). The relatively high number of EBV-positive small lymphocytes detected in Hodgkin's disease and T-cell lymphoma compared with B-cell lymphoma may account for the greater percentage of EBV- positive tumors obtained in SCID mice. Our results show that SCID mice do not provide the growth conditions that are required for in vivo growth of RS cells. We noted in some SCID tumors, the presence of binucleated and/or multinucleated giant cells resembling RS cells. However, the presence of such cells was not restricted to mice grafted with lymph nodes involved by Hodgkin's disease. We postulate that in previous reports, cells resembling RS cells were just binucleated EBV- positive lymphoma blastoid cells rather than actual RS cells.

scholarly journals B Lymphocytes in Untreated Patients with Malignant Lymphoma and Hodgkin's Disease

1973 ◽  
Vol 52 (12) ◽  
pp. 3064-3073 ◽  
Author(s):  
Kazimiera J. Gajl-Peczalska ◽  
John A. Hansen ◽  
Clara D. Bloomfield ◽  
Robert A. Good
Keyword(s):  
Malignant Lymphoma ◽  
B Lymphocytes ◽  
Hodgkin's Disease ◽  
Hodgkin’S Disease
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