Comparison of mathematical models for the maternal age dependence of Down's syndrome rates

1981 ◽  
Vol 59 (3) ◽  
Author(s):  
ScottH. Lamson ◽  
ErnestB. Hook
Keyword(s):  
Mathematical Models ◽  
Maternal Age ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Age Dependence

Incidence of Down's Syndrome by Maternal Age of Asian Population

2020 ◽  
Author(s):  
Song Yi ◽  
Jieping Song ◽  
Feng Liu ◽  
Xu Liu ◽  
Chengcheng Zhang ◽  
...  
Keyword(s):  
Maternal Age ◽  
Down's Syndrome ◽  
Asian Population ◽  
Down’S Syndrome

A study of maternal age in Down's syndrome

1966 ◽  
Vol 29 (3) ◽  
pp. 271-276 ◽  
Author(s):  
HANS OLOF ÅKESSON ◽  
H. HANS FORSSMAN
Keyword(s):  
Maternal Age ◽  
Down's Syndrome ◽  
Down’S Syndrome

scholarly journals Reliability of Statistics on Down's Syndrome Notifications

1997 ◽  
Vol 4 (2) ◽  
pp. 95-97 ◽  
Author(s):  
T Huang ◽  
H C Watt ◽  
N J Wald ◽  
J K Morris ◽  
D Mutton ◽  
...  
Keyword(s):  
Maternal Age ◽  
Antenatal Diagnosis ◽  
Down's Syndrome ◽  
Age Distribution ◽  
Down’S Syndrome ◽  
England And Wales ◽  
Birth Prevalence ◽  
Live Births ◽  
National Statistics ◽  
Using Data

Objectives— To evaluate the completeness of notifications of Down's syndrome live births and terminations to the Office for National Statistics (ONS) using data from the National Down Syndrome Cytogenetic Register (NDSCR). To examine the agreement of observed birth prevalence of Down's syndrome with the expected birth prevalence derived from published maternal age specific rates. Methods— The number of live births (adjusted to allow for the estimated under-ascertainment) and the number of terminations due to fetal Down's syndrome from NDSCR were compared with those figures reported to the ONS. Subsequently, using the NDSCR figures, the live birth prevalence of Down's syndrome that would have occurred in the absence of antenatal diagnosis and selective termination was calculated in England and Wales in the years 1990–1993. These figures were compared with those derived by applying published age specific prevalences to the maternal age distribution in England and Wales. Results— It is estimated that only 48% and 46% respectively of Down's syndrome live births and terminations of pregnancy were notified to ONS between 1990 and 1993. The annual expected birth prevalences of Down's syndrome obtained by applying maternal age specific prevalences to the maternal age distribution were in close agreement with observed rates from NDSCR. Conclusions— There is considerable underreporting of Down's syndrome births and terminations to ONS. The NDSCR data are more complete and therefore the effects of screening should be monitored using data from this source, or using estimates derived from the age specific rates of Down's syndrome.

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