scholarly journals Poor metabolic control, hypertension and microangiopathy independently increase the transcapillary escape rate of albumin in diabetes

Diabetologia ◽  
1983 ◽  
Vol 25 (3) ◽  
pp. 260-263 ◽  
Author(s):  
J. A. O'Hare ◽  
J. B. Ferriss ◽  
B. Twomey ◽  
D. J. O'Sullivan
Keyword(s):  
Metabolic Control ◽  
Escape Rate ◽  
Poor Metabolic Control ◽  
Transcapillary Escape Rate

Changes in Blood Pressure, Body Fluids, Circulating Angiotensin II and Aldosterone, with Improved Diabetic Control

1982 ◽  
Vol 63 (s8) ◽  
pp. 415s-418s ◽  
Author(s):  
J. A. O'hare ◽  
J. B. Ferriss ◽  
B. M. Twomey ◽  
H. Gonggrijp ◽  
D. J. O'sullivan
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Metabolic Control ◽  
Plasma Volume ◽  
Diabetic Control ◽  
Escape Rate ◽  
Diabetic Patients ◽  
Exchangeable Sodium ◽  
Poor Metabolic Control ◽  
Transcapillary Escape Rate

1. We studied 12 normotensive non-ketotic diabetic patients during poor metabolic control, with sustained hyperglycaemia, and again, after an interval of 3 weeks, when metabolic control was improved. On each occasion we measured blood pressure, total exchangeable sodium, plasma volume, transcapillary escape rate of albumin, and plasma concentrations of angiotensin II and aldosterone. 2. With improved diabetic control there was a small but significant fall in arterial pressure. Total exchangeable sodium was normal when control was poor but rose significantly to above normal with improved control. 3. Plasma volume also rose significantly with improved control, and the transcapillary escape rate of albumin fell and the intravascular mass of albumin rose. 4. Plasma angiotensin II and aldosterone concentrations were significantly above normal during poor metabolic control, but fell to normal with improved control. 5. These findings indicate a resetting of the relationship between blood pressure and exchangeable sodium when diabetic control improves. The association between exchangeable sodium and concentrations of angiotensin II and aldosterone also appears altered in diabetic patients. These changes associated with varying metabolic control must be considered when studying cardiovascular disease in diabetic patients.

Increased transcapillary escape rate of albumin in nondiabetic men in response to hyperinsulinemia

Diabetes ◽  
1990 ◽  
Vol 39 (10) ◽  
pp. 1212-1217 ◽  
Author(s):  
J. E. Nestler ◽  
C. O. Barlascini ◽  
G. A. Tetrault ◽  
M. J. Fratkin ◽  
J. N. Clore ◽  
...  
Keyword(s):  
Escape Rate ◽  
Transcapillary Escape Rate

scholarly journals Large Neutral Amino Acids (LNAAs) Supplementation Improves Neuropsychological Performances in Adult Patients with Phenylketonuria

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1092 ◽  
Author(s):  
Iris Scala ◽  
Maria Pia Riccio ◽  
Maria Marino ◽  
Carmela Bravaccio ◽  
Giancarlo Parenti ◽  
...  
Keyword(s):  
Amino Acids ◽  
Executive Functions ◽  
Metabolic Control ◽  
Cognitive Functions ◽  
Well Being ◽  
Wisconsin Card Sorting Test ◽  
Card Sorting ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids ◽  
Poor Metabolic Control

Phenylketonuria is an inborn error of phenylalanine (Phe) metabolism diagnosed by newborn screening and treated early with diet. Although diet prevents intellectual disability, patients often show impairment of executive functions, working memory, sustained attention, and cognitive flexibility. Large neutral amino acids (LNAAs) have been proposed as a dietary supplement for PKU adults. Few studies show that LNAAs may help in improving metabolic control as well as cognitive functions. In this study, 10 adult PKU patients with poor metabolic control were treated for 12 months with LNAAs (MovisCom, 0.8–1 g/kg/day) and underwent Phe and Tyrosine (Tyr) monitoring monthly. Neuropsychological assessment was performed at T0, T+3, and T+12 months by using the American Psychological General Well-Being Index, the Wisconsin Card Sorting Test, the Test of Attentional Performance, and the 9-Hole Peg Test. No change in plasma Phe levels was observed during LNAAs supplementation, while Tyr levels significantly improved during LNAAs supplementation (p = 0.03). Psychometric tests showed an improvement of distress and well-being rates, of executive functions, attention, and vigilance, whereas no difference was noted regarding hand dexterity. This study adds evidence of the advantage of LNAAs supplementation in improving cognitive functions and well-being in patients with PKU with poor metabolic control.

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control

2015 ◽  
Vol 243 (2) ◽  
pp. 638-644 ◽  
Author(s):  
Daniel M. Mueller ◽  
Martina Allenspach ◽  
Alaa Othman ◽  
Christoph H. Saely ◽  
Axel Muendlein ◽  
...  
Keyword(s):  
Metabolic Control ◽  
Kidney Function ◽  
Plasma Levels ◽  
Poor Metabolic Control
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