emb-5, a gene required for the correct timing of gut precursor cell division during gastrulation in Caenorhabditis elegans, encodes a protein similar to the yeast nuclear protein SPT6

1993 ◽  
Vol 239 (3) ◽  
pp. 313-322 ◽  
Author(s):  
Kiyoji Nishiwaki ◽  
Tohru Sano ◽  
Johji Miwa
Keyword(s):  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Nuclear Protein ◽  
Precursor Cell

scholarly journals The EGL-13 SOX Domain Transcription Factor Affects the Uterine Cell Lineages in Caenorhabditis elegans

Genetics ◽  
2003 ◽  
Vol 165 (3) ◽  
pp. 1623-1628
Author(s):  
Hediye Nese Cinar ◽  
Keri L Richards ◽  
Kavita S Oommen ◽  
Anna P Newman
Keyword(s):  
Transcription Factor ◽  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Cell Fate ◽  
Cell Lineages

Abstract We isolated egl-13 mutants in which the cells of the Caenorhabditis elegans uterus initially appeared to develop normally but then underwent an extra round of cell division. The data suggest that egl-13 is required for maintenance of the cell fate.

scholarly journals A complex containing the Sm protein CAR-1 and the RNA helicase CGH-1 is required for embryonic cytokinesis in Caenorhabditis elegans

2005 ◽  
Vol 171 (2) ◽  
pp. 267-279 ◽  
Author(s):  
Anjon Audhya ◽  
Francie Hyndman ◽  
Ian X. McLeod ◽  
Amy S. Maddox ◽  
John R. Yates ◽  
...  
Keyword(s):  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Rna Binding ◽  
Rna Binding Protein ◽  
Rna Helicase ◽  
Aurora B ◽  
Aurora B Kinase ◽  
Daughter Cells ◽  
Sm Protein ◽  
Spindle Structure

Cytokinesis completes cell division and partitions the contents of one cell to the two daughter cells. Here we characterize CAR-1, a predicted RNA binding protein that is implicated in cytokinesis. CAR-1 localizes to germline-specific RNA-containing particles and copurifies with the essential RNA helicase, CGH-1, in an RNA-dependent fashion. The atypical Sm domain of CAR-1, which directly binds RNA, is dispensable for CAR-1 localization, but is critical for its function. Inhibition of CAR-1 by RNA-mediated depletion or mutation results in a specific defect in embryonic cytokinesis. This cytokinesis failure likely results from an anaphase spindle defect in which interzonal microtubule bundles that recruit Aurora B kinase and the kinesin, ZEN-4, fail to form between the separating chromosomes. Depletion of CGH-1 results in sterility, but partially depleted worms produce embryos that exhibit the CAR-1–depletion phenotype. Cumulatively, our results suggest that CAR-1 functions with CGH-1 to regulate a specific set of maternally loaded RNAs that is required for anaphase spindle structure and cytokinesis.

scholarly journals The nucleoporin Nup205/NPP-3 is lost near centrosomes at mitotic onset and can modulate the timing of this process in Caenorhabditis elegans embryos

2012 ◽  
Vol 23 (16) ◽  
pp. 3111-3121 ◽  
Author(s):  
Virginie Hachet ◽  
Coralie Busso ◽  
Mika Toya ◽  
Asako Sugimoto ◽  
Peter Askjaer ◽  
...  
Keyword(s):  
Cell Division ◽  
Rna Interference ◽  
Caenorhabditis Elegans ◽  
Nuclear Envelope ◽  
Aurora A Kinase ◽  
Aurora A ◽  
Time And Space ◽  
Local Loss ◽  
Necessary And Sufficient

Regulation of mitosis in time and space is critical for proper cell division. We conducted an RNA interference–based modifier screen to identify novel regulators of mitosis in Caenorhabditis elegans embryos. Of particular interest, this screen revealed that the Nup205 nucleoporin NPP-3 can negatively modulate the timing of mitotic onset. Furthermore, we discovered that NPP-3 and nucleoporins that are associated with it are lost from the nuclear envelope (NE) in the vicinity of centrosomes at the onset of mitosis. We demonstrate that centrosomes are both necessary and sufficient for NPP-3 local loss, which also requires the activity of the Aurora-A kinase AIR-1. Our findings taken together support a model in which centrosomes and AIR-1 promote timely onset of mitosis by locally removing NPP-3 and associated nucleoporins from the NE.

scholarly journals lin-8, Which Antagonizes Caenorhabditis elegans Ras-Mediated Vulval Induction, Encodes a Novel Nuclear Protein That Interacts With the LIN-35 Rb Protein

Genetics ◽  
2005 ◽  
Vol 171 (3) ◽  
pp. 1017-1031 ◽  
Author(s):  
Ewa M. Davison ◽  
Melissa M. Harrison ◽  
Albertha J. M. Walhout ◽  
Marc Vidal ◽  
H. Robert Horvitz
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Protein ◽  
Rb Protein

scholarly journals Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates

2015 ◽  
Vol 472 (3) ◽  
pp. 329-338 ◽  
Author(s):  
Malik M. Keshwani ◽  
Kendra L. Hailey ◽  
Brandon E. Aubol ◽  
Laurent Fattet ◽  
Maria L. McGlone ◽  
...  
Keyword(s):  
Cell Division ◽  
Protein Kinase ◽  
Nuclear Protein ◽  
Cell Division Cycle ◽  
Protein Substrates ◽  
Docking Mechanism ◽  
Physiological Substrates

CLK1 (Cdc (cell division cycle)2-like kinase 1) uses an oligomerization mechanism to recognize its physiological protein substrates.

Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans

2007 ◽  
Vol 313 (7) ◽  
pp. 1460-1472 ◽  
Author(s):  
Qiongmei Ji ◽  
Cheng-Han Huang ◽  
Jianbin Peng ◽  
Sarwar Hashmi ◽  
Tianzhang Ye ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Protein

scholarly journals Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

1987 ◽  
Vol 105 (5) ◽  
pp. 2123-2135 ◽  
Author(s):  
A A Hyman ◽  
J G White
Keyword(s):  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Early Embryogenesis ◽  
The Other ◽  
Nuclear Complex ◽  
Centrosome Separation

The establishment of cell division axes was examined in the early embryonic divisions of Caenorhabditis elegans. It has been shown previously that there are two different patterns of cleavage during early embryogenesis. In one set of cells, which undergo predominantly determinative divisions, the division axes are established successively in the same orientation, while division axes in the other set, which divide mainly proliferatively, have an orthogonal pattern of division. We have investigated the establishment of these axes by following the movement of the centrosomes. Centrosome separation follows a reproducible pattern in all cells, and this pattern by itself results in an orthogonal pattern of cleavage. In those cells that divide on the same axis, there is an additional directed rotation of pairs of centrosomes together with the nucleus through well-defined angles. Intact microtubules are required for rotation; rotation is prevented by inhibitors of polymerization and depolymerization of microtubules. We have examined the distribution of microtubules in fixed embryos during rotation. From these and other data we infer that microtubules running from the centrosome to the cortex have a central role in aligning the centrosome-nuclear complex.

Using fast-acting temperature-sensitive mutants to study cell division in Caenorhabditis elegans

2017 ◽  
pp. 283-306 ◽  
Author(s):  
T. Davies ◽  
S. Sundaramoorthy ◽  
S.N. Jordan ◽  
M. Shirasu-Hiza ◽  
J. Dumont ◽  
...  
Keyword(s):  
Cell Division ◽  
Caenorhabditis Elegans ◽  
Temperature Sensitive ◽  
Temperature Sensitive Mutants ◽  
Fast Acting
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