scholarly journals Insulin autoantibodies at the clinical manifestation of Type 1 (insulin-dependent) diabetes ? a poor predictor of clinical course and antibody response to exogenous insulin

Diabetologia ◽  
1988 ◽  
Vol 31 (3) ◽  
pp. 129-133 ◽  
Author(s):  
J. Karjalainen ◽  
M. Knip ◽  
A. Mustonen ◽  
H. K. �kerblom
2008 ◽  
Vol 2008 ◽  
pp. 1-15 ◽  
Author(s):  
Daisuke Takahashi ◽  
Yang Xiao ◽  
Fei Hu ◽  
Michael Lewis

This paper surveys diabetes therapies from telemedicine viewpoint. In type 1 diabetes therapies, the exogenous insulin replacement is generally considered as a primary treatment. However, the complete replacement of exogenous insulin is still a challenging issue because of its complexity of modeling the dynamics, which is typically modeled nonlinearly. On the other hand, thanks to the progress of medical devices, currently the diabetes therapies are being automated. These medical devices include automated insulin pumps and blood glucose sensors. Insulin pumps are designed to create artificial insulin perfusion while they largely rely on the blood glucose profile measurements and these measurements are achieved by one or more blood glucose sensors. The blood glucose measurements are also important for the insulin-dependent diabetes therapies. An insulin pump along with sensors establishes a good feedback system providing the appropriate amount of the exogenous insulin on demand. Controlling the amount of exogenous insulin to suppress the blood glucose levels requires complicated computations. This paper mostly explains both type 1 and 2 diabetes and their mechanisms accompanied by descriptions of diabetes therapy and medical devices currently utilized in the therapy.


Metabolism ◽  
1988 ◽  
Vol 37 (11) ◽  
pp. 1005-1007 ◽  
Author(s):  
Mark Sutton ◽  
Leslie J. Klaff ◽  
Chris M. Asplin ◽  
Peter Clemons ◽  
Olga Tatpati ◽  
...  

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