scholarly journals Diabetic nephropathy and arterial hypertension

Diabetologia ◽  
1983 ◽  
Vol 24 (1) ◽  
Author(s):  
H.-H. Parving ◽  
A.R. Andersen ◽  
U.M. Smidt ◽  
B. Oxenb�ll ◽  
B. Edsberg ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Arterial Hypertension

scholarly journals ASSESSMENT OF NEPHRIN AND PODOCIN LEVELS IN THE URINE OF PATIENTS WITH DIABETES MELLITUS

2017 ◽  
Vol 21 (2) ◽  
pp. 33-40
Author(s):  
I. N. Bobkova ◽  
A. A. Shchukina ◽  
M. V. Shestakova
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Arterial Hypertension ◽  
Healthy Subjects ◽  
Early Diagnostics ◽  
Urinary Levels ◽  
Patients With Diabetes ◽  
Early Diabetic Nephropathy

THE AIM:to assess excretion value of podocytes injury biomarkers in urine and to clarify their significance for early diabetic nephropathy (DN) diagnostics in diabetes mellitus (DM) patients with different severity of albuminuria (AU)/proteinuria(PU).PATIENTS AND METHODS.74 DM pts were studied, including 30 with type1 DM (T1DM) and 44 pts with type2 DM (T2DM). They were divided into three groups: 41 pts with AU <30 mg/gCr (A1), 13 pts with AU 30-300 mg/gCr (A2), 20 pts with PU (A3). CKD S1 was revealed in 41pts, CKD S2 – in 25 pts, CKD S3 – in 8 pts. Arterial hypertension was observed in 52 pts of 74(70%), mainly in T2DM. 10 healthy subjects were studied as control. Urinary levels of nephrin and podocin (an important slit diaphragm proteins) were measured by ELISA.RESULTS.Nephrinuria (NU) >5,84ng/ml/g, which not detecting in controls, was revealed in 63% of A1 pts, in 77% – in A2, in 80% – in A3. Podocinuria (PdU)>1,73ng/ml/g was revealed in 78% of A1 pts, in 54% of A2 and in 83% – A3. NU in pts with PU was significantly higher than in AU<30 mg/g. PDU in groups with different AU/PU was equally high and has no differ between DM types. Direct correlation was obtained between NU and AU (R=0,947 p<0,05). NU and PdU in T1DM correlated directly with serum creatinine (R=0,489 p<0,05 and R=0,468 p<0,05) and indirectly with GFR (R=-0,461 p<0,05 and R=-0,36 р<0,05). In DM duration less than 5 years NU directly correlated with НbА1с level, in T2DM – indirectly with systolic blood pressure.CONCLUSON. Nephrin and podocin levels can be useful for early diagnostics and monitoring of DN. 

scholarly journals Effectiveness of atorvastatin therapy in patients with arterial hypertension, diabetic nephropathy and diabetes mellitus type 2

2019 ◽  
pp. 105-110
Author(s):  
O. M. Chernatska ◽  
T. S. Mazur ◽  
N. V. Demikhova ◽  
O. M. Vlasenko ◽  
T. M. Rudenko ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Arterial Hypertension ◽  
Lipid Profile ◽  
Cardiovascular Complications ◽  
Actual Problem ◽  
Type 2 Dm

The actual problem of internal medicine is the managemen of patients with comorbid pathology. Arterial hypertension (AH) is determined in about quarter of the population in the world. Moreover, the coexistence of AH and type 2 diabetes mellitus (DM) connected with the increased risk of cardiovascular complications (CVC) compared with patients with AH. In principle dyslipidemia is the common link between AH and type 2 DM, which need the correction. No doubt that reduction of atherogenic and increase of anti atherogenic lipoproteins is necessary for persons with comorbid pathology. The objective of our study was the assessment of atorvastatin treatment in patients with AH, diabetic nephropathy and type 2 DM. We obtained 96 patients with AH, diabetic nephropathy and type 2 DM (І group), 25 persons with AH (ІІ group), 15 conditionally healthy individuals. Persons had CVC in the past. For patients from the І and ІІ group CVC were defined accordingly (4,97 ± 0,20) years and (4,10 ± 0,05) years ago (P = 0,0291). The duration of AH is (8,1 ± 0,2) years for the І group and (8,90 ± 0,13) years for the ІІ group. The levels of lipid profile spectrum were determined according to the methods of W. T. Friedewald. The results of investigation were analyzed with the help of Microsoft Excel 2016. Correction of lipid profile spectrum is the important part of multipurpose treatment for persons with coexistent pathology. All patients were treated by atorvastatin (10−40 mg/day) during 6 months in a complex therapy. The target levels of general cholesterol during 6 months were presented in 30 persons (31.91 %), low density lipoproteids – in 10 persons (10.64 %), high density lipoproteids – in 26 persons (27.66 %), triglycerides – in 34 persons (36.17 %) among patients with AH, diabetic nephropathy and type 2 DM. In conclusion, it is advisable to prescribe atorvastatin (10–40 mg/day) for correction of dyslipidemia, reduction of proatherogenic orientation, prevention of atherosclerotic process manifestation and cardiovascular complications in patients with AH with diabetic nephropathy and type 2 diabetes mellitus.

scholarly journals Structural, functional and endothelial peculiarities of diabetic nephropathy in patients with arterial hypertension

2018 ◽  
pp. 13-17
Author(s):  
О. M. Chernatska ◽  
N. V. Demikhova
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Arterial Hypertension ◽  
Glycosylated Hemoglobin ◽  
Albumin Excretion Rate ◽  
Endothelin 1 ◽  
Patients With Diabetes

The aim of our one-stage observational study was the detail analysis of structural, functional, endothelial peculiarities of diabetic nephropathy in patients with coexistent arterial hypertension. Methods. Our study involved 96people with arterial hypertension and type 2 diabetes mellitus (I group), 25 patients with arterial hypertension (II group), 15 practically healthy persons (III group) treated and obtained in Sumy City Clinical Hospital №1. Cardiovascular complications were determined in all patients from I and II groups. The average age of the patients was 62.31 ± 0.2 years. The level of glycosylated hemoglobin (HbAlc) was determined by the biochemical method, albuminuria by immunoassay. The level of endothelin-1 (ET-1) in serum was studied using ELISA. Results. It was found that the level of ET-1 was significantly higher in patients with diabetes compared with only hypertensive patients. In the patients with urine albumin excretion rate category A2 the level of endothelin-1 was significantly higher compared with the category A1 patients and less compared with category A3 patients (11.42 ± 49 vs 25 ± 0.57pg/ml, p = 0.0329 and 11.42 ± 0.49 vs 2.25 ± 1.04pg/ml, p <0.0001, respectively. So, the level of ET-1 increased in proportion to albuminuria. In patients with the albuminuria category A2, the endothelin-1 level was higher than in subjects with the A1 category and lower than in patients with the A3 category. In addition, we identified a moderate direct correlation between the blood level of ET-1 in the patients with diabetes and blood glucose level (r = 0.29;p = 0.004). Conclusion. Finally, it is the confirmation of greater endothelial function disorders for arterial hypertension and type 2 diabetes mellitus. In conclusion, endothelial dysfunction promotes diabetic nephropathy progression.

Diabetic Nephropathy and Arterial Hypertension: The Effect of Antihypertensive Treatment

Diabetes ◽  
1983 ◽  
Vol 32 (Supplement_2) ◽  
pp. 83-87 ◽  
Author(s):  
H.-H. Parving ◽  
A. R. Andersen ◽  
U. M. Smidt ◽  
J. S. Christiansen ◽  
B. Oxenboll ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Arterial Hypertension ◽  
Antihypertensive Treatment

scholarly journals Response of fibroblast growth factor 23 to volume interventions in arterial hypertension and diabetic nephropathy

Medicine ◽  
2016 ◽  
Vol 95 (46) ◽  
pp. e5003 ◽  
Author(s):  
Jelmer K. Humalda ◽  
Sarah Seiler-Muler ◽  
Arjan J. Kwakernaak ◽  
Marc G. Vervloet ◽  
Gerjan Navis ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Growth Factor ◽  
Arterial Hypertension ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth

scholarly journals Reliability of peripheral arterial tonometry in patients with heart failure, diabetic nephropathy and arterial hypertension

2017 ◽  
Vol 22 (4) ◽  
pp. 292-300 ◽  
Author(s):  
Fabian Weisrock ◽  
Max Fritschka ◽  
Sebastian Beckmann ◽  
Simon Litmeier ◽  
Josephine Wagner ◽  
...  
Keyword(s):  
Heart Failure ◽  
Diabetic Nephropathy ◽  
Endothelial Dysfunction ◽  
Ejection Fraction ◽  
Arterial Hypertension ◽  
Peripheral Arterial Tonometry ◽  
Clinical Trial Registration ◽  
Good Reliability ◽  
Reliable Technique ◽  
Reduced Ejection Fraction

Endothelial dysfunction plays a major role in cardiovascular diseases and pulse amplitude tonometry (PAT) offers a non-invasive way to assess endothelial dysfunction. However, data about the reliability of PAT in cardiovascular patient populations are scarce. Thus, we evaluated the test-retest reliability of PAT using the natural logarithmic transformed reactive hyperaemia index (LnRHI). Our cohort consisted of 91 patients (mean age: 65±9.7 years, 32% female), who were divided into four groups: those with heart failure with preserved ejection fraction (HFpEF) ( n=25), heart failure with reduced ejection fraction (HFrEF) ( n=22), diabetic nephropathy ( n=21), and arterial hypertension ( n=23). All subjects underwent two separate PAT measurements at a median interval of 7 days (range 4–14 days). LnRHI derived by PAT showed good reliability in subjects with diabetic nephropathy (intra-class correlation (ICC) = 0.863) and satisfactory reliability in patients with both HFpEF (ICC = 0.557) and HFrEF (ICC = 0.576). However, in subjects with arterial hypertension, reliability was poor (ICC = 0.125). We demonstrated that PAT is a reliable technique to assess endothelial dysfunction in adults with diabetic nephropathy, HFpEF or HFrEF. However, in subjects with arterial hypertension, we did not find sufficient reliability, which can possibly be attributed to variations in heart rate and the respective time of the assessments. Clinical Trial Registration Identifier: NCT02299960.

scholarly journals DOPLEROGRAPHIC DESCRIPTION OF RENAL BLOOD SUPPLY DISTURBANCE IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE I-II AND ARTERIAL HYPERTENSION

2016 ◽  
pp. 66-70
Author(s):  
L.O. Zub ◽  
S.D. Novychenko ◽  
О.І. Novychenko
Keyword(s):  
Blood Flow ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
Arterial Hypertension ◽  
Blood Supply ◽  
Chronic Renal Disease ◽  
Blood Velocity ◽  
Stage I ◽  
Stage Ii ◽  
Disease Stage

The purpose of this work was to investigate renal blood supply disturbance in patients with chronic renal disease stage I-II (pyelonephritis, glomerulonephritis, diabetic nephropathy). Material and methods. The authors carried out 131 complex ultrasonic investigations using ultrasonic duplex color kidney scanning. 47patients with chronic pyelonephritis (ChPN), 48patients with diabetic nephropathy stage IV (DN) and 36patients with chronic glomerulonephritis (ChGN) were involved into investigation. Each group consisted of 2 subgroups – with arterial hypertension (AH) and without AH. 20 healthy persons were examined as well. Results. Scantyintrarenal blood flow which is characterized with a decrease of maximal systolic (Vs), minimal diastolic blood velocity(Vd), as well as a decrease of indices of the averaged, according to time, maximal blood velocity (TAMX) and volumetric blood velocity (Vvol) and an increase of index resistance (IR) have been revealed in patients with chronic renal disease (ChRD) stage I-II with the presence of AH stage II. Indices of the vascular renal blood flow under study correlated with the main factors of ChRD progression – glomerular filtration rate (GFR) and daily proteinuria. Conclusion. Reliable Vs, Vd, TAMX and Vvol decrease and a reliable IR increase may be considered as early noninvasive criteria of ChRD progression with the presence of AH stage II.

scholarly journals Arterial hypertension in patients with type 1 diabetes mellitus and orthostatic disorders and its correction: Clinical features and possibilities of correction

2010 ◽  
Vol 16 (4) ◽  
pp. 418-422
Author(s):  
V. V. Schekotov ◽  
S. G. Shulkina ◽  
A. A. Antipova ◽  
O. V. Shanko ◽  
N. L. Kiseleva
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Cognitive Function ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Cognitive Disorders ◽  
Dyscirculatory Encephalopathy ◽  
Design And Methods ◽  
State Examination

Objective. To characterize diabetic nephropathy and cognitive function in patients with arterial hypertension (AH) and diabetes mellitus (DM) type 1, complicated by orthostatic hypotension (OH), and to assess the benefits of venoprotector therapy for the correction of dyscirculatory encephalopathy (DE) and diabetic nephropathy (DN). Design and methods. Sixty patients with AH, DM type 1 and OH were included in the study. Schellongs' orthostatic probe, microalbuminuria (MAU) screening with «Micral-Test-11», Mini Mental State examination (MMSE) test, 10 words memo probe, Spielberg test, Beck questionnaire were used. Antihypertensive therapy included «Enalapril» («Hemofarm», Serbia), venoprotective therapy - with «Detralex» («Servier», France). Results. Adequate antihypertensive therapy in patients with DM type 1 in combination with AH and OH leads to aggravation of postural hypertension symptoms. Blood pressure decrease in orthostatic probe and cognitive disorders are associated (r = 0,56, p = 0,009). Use of active orthostatic probe (AOP) leads to the increase of MAU. Venotonic therapy attenuates the symptoms of postural hypotension, leads to the decrease of MAU in AOP and improves cognitive function.

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