scholarly journals Long-term effects of cyclosporin A on cultured mouse pancreatic islets

Diabetologia ◽  
1984 ◽  
Vol 27 (S1) ◽  
pp. 66-69 ◽  
Author(s):  
A. Andersson ◽  
H. Borg ◽  
A. Hallberg ◽  
C. Hellerstr�m ◽  
S. Sandler ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Pancreatic Islets ◽  
Long Term Effects ◽  
Mouse Pancreatic Islets

scholarly journals Does early weaning have both short‐ and long‐term effects on pancreatic islets and skeletal muscle?

2020 ◽  
Vol 598 (17) ◽  
pp. 3553-3554
Author(s):  
Reganne K. Briggs ◽  
Caleb C. Reichhardt ◽  
Austin Sears
Keyword(s):  
Skeletal Muscle ◽  
Pancreatic Islets ◽  
Early Weaning ◽  
Long Term Effects ◽  
Short And Long Term

Early weaning induces short‐ and long‐term effects on pancreatic islets in Wistar rats of both sexes

2020 ◽  
Vol 598 (3) ◽  
pp. 489-502 ◽  
Author(s):  
Carla Bruna Pietrobon ◽  
Rosiane Aparecida Miranda ◽  
Iala Milene Bertasso ◽  
Paulo Cezar de Freitas Mathias ◽  
Maria Lúcia Bonfleur ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Wistar Rats ◽  
Early Weaning ◽  
Long Term Effects ◽  
Short And Long Term

Verapamil and cyclosporin a sensitize human kidney tumor cells to vincristine in absence of membrane P-glycoprotein and without apparent changes in the cytoplasmic free Ca2+ concentration

1990 ◽  
Vol 10 (2) ◽  
pp. 231-237 ◽  
Author(s):  
P. Nygren ◽  
R. Larsson
Keyword(s):  
Cyclosporin A ◽  
Drug Sensitivity ◽  
Human Kidney ◽  
Chemotherapeutic Drug ◽  
Long Term Effects ◽  
Adenocarcinoma Cell Line ◽  
Glycoprotein P ◽  
P Glycoprotein ◽  
Sensitizing Effect

Vincristine (Vcr) dose dependently inhibited growth of the kidney adenocarcinoma cell line ACHN during 4 days of culture. Verapamil (Ver) at 10 μM and cyclosporin A (CsA) at 1 μg/ml had no effect on cell growth but significantly potentiated the action of Vcr, despite the absence of the multidrug resistance associated membrane P-glycoprotein (P-gp). Neither Ver nor CsA had any acute or long term effects on cytoplasmic free Ca2+ concentration (Ca2+i), except for a small Ver induced increase after 36 h of incubation. The results indicate that Ver and CsA may have a sensitizing effect on chemotherapeutic drug sensitivity also in absence of P-gp. However, these effects are probably not mediated by changes in Ca2+i.

scholarly journals Follow-up of cyclosporin A treatment in Type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects

Diabetologia ◽  
1991 ◽  
Vol 34 (6) ◽  
pp. 429-434 ◽  
Author(s):  
S. Martin ◽  
G. Schernthaner ◽  
J. Nerup ◽  
F. A. Gries ◽  
V. A. Koivisto ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Cyclosporin A ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Long Term Effects ◽  
Insulin Dependent

scholarly journals Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon

Diabetologia ◽  
2008 ◽  
Vol 51 (9) ◽  
pp. 1689-1693 ◽  
Author(s):  
S. C. Collins ◽  
A. Salehi ◽  
L. Eliasson ◽  
C. S. Olofsson ◽  
P. Rorsman
Keyword(s):  
Pancreatic Islets ◽  
Mouse Pancreatic Islets

Effects of cyclosporin A and verapamil on mouse pancreatic islets

1993 ◽  
Vol 129 (1) ◽  
pp. 54-58 ◽  
Author(s):  
Chun L Shi ◽  
Pål Rooth ◽  
Inge-Bert Täljedal
Keyword(s):  
Cyclosporin A ◽  
Pancreatic Islets ◽  
Plasma Glucose ◽  
Plasma Insulin ◽  
Nmri Mice ◽  
Mouse Pancreatic Islets ◽  
Beneficial Action ◽  
Primary Interaction

Treatment of NMRI mice with cyclosporin A (25 mg/kg body wt) for 11 days caused a marked fall in pancreas insulin content, although plasma glucose and plasma insulin were unchanged. When islets from untreated mice were exposed to cyclosporin A (2 mg/l) in vitro, no effect was seen in the first hour. After 24 h, cyclosporin A had significantly decreased the islet content of insulin. Post-culture microperifusion showed that cyclosporin A for 24 or 72 h inhibited the insulin secretory responsiveness. Verapamil in vivo (0.4 mg/kg body wt per day) or in vitro (37.5 μg/l) did not modify these effects. Verapamil at 25 mg/l suppressed the release of insulin but afforded no obvious protection against cyclosporin A during culture. The beneficial action of verapamil on islets transplanted to the kidney may reflect renal events rather than a primary interaction of drugs in the islets.

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