Long-range restriction map of a region of human chromosome 19 containing the apolipoprotein genes, a CLL-associated translocation breakpoint, and two polymorphic MluI sites

1989 ◽  
Vol 83 (1) ◽  
pp. 71-74 ◽  
Author(s):  
Duncan J. Shaw ◽  
Helen G. Harley ◽  
J. David Brook ◽  
Timothy W. McKeithan
Keyword(s):  
Human Chromosome ◽  
Long Range ◽  
Translocation Breakpoint ◽  
Restriction Map ◽  
Chromosome 19 ◽  
Range Restriction ◽  
Human Chromosome 19

Long range restriction map of the von Hippel-Lindau gene region on human chromosome 3p

1993 ◽  
Vol 92 (3) ◽  
Author(s):  
SusanneC. Szymanski ◽  
Holger Hummerich ◽  
Farida Latif ◽  
MichaelI. Lerman ◽  
Gunter R�hrborn ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Long Range ◽  
Gene Region ◽  
Restriction Map ◽  
Range Restriction ◽  
Von Hippel Lindau ◽  
Chromosome 3P

A long range restriction map spanning the myxoid liposarcoma breakpoint in the q13-14 region of human chromosome 12

1994 ◽  
Vol 94 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Anne Forus ◽  
Patrick F. J. Kools ◽  
Eric F. P. M. Schoenmakers ◽  
Wim J. M. Van de Ven ◽  
Ola Myklebost
Keyword(s):  
Human Chromosome ◽  
Long Range ◽  
Myxoid Liposarcoma ◽  
Chromosome 12 ◽  
Restriction Map ◽  
Range Restriction

A Long-Range Restriction Map of Human Chromosome 5q21-q23

Genomics ◽  
1993 ◽  
Vol 17 (1) ◽  
pp. 15-24 ◽  
Author(s):  
J.R.Tristan Ward ◽  
Sally Cottrell ◽  
Huw J.W. Thomas ◽  
Tania A. Jones ◽  
Cathy M. Howe ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Long Range ◽  
Restriction Map ◽  
Range Restriction

A prostate-derived cDNA that is mapped to human chromosome 19 encodes a novel protein

2002 ◽  
Vol 296 (2) ◽  
pp. 281-287 ◽  
Author(s):  
Chiang Wang ◽  
Ida M McCarty ◽  
Louisa Balazs ◽  
Yi Li ◽  
Mitchell S Steiner
Keyword(s):  
Human Chromosome ◽  
Chromosome 19 ◽  
Human Chromosome 19 ◽  
Novel Protein

scholarly journals CpG island mapping of a mouse double-minute chromosome.

1993 ◽  
Vol 13 (8) ◽  
pp. 4459-4464 ◽  
Author(s):  
J L Beland ◽  
J A Longo ◽  
P J Hahn
Keyword(s):  
Cell Line ◽  
Long Range ◽  
Molecular Mechanisms ◽  
Cpg Island ◽  
Single Copy ◽  
Restriction Map ◽  
Chromosomal Dna ◽  
Dhfr Gene ◽  
Range Restriction ◽  
Double Minute

The development of double-minute chromosomes (DMs) and subsequent gene amplification are important genomic alterations resulting in increased oncogene expression in a variety of tumors. The molecular mechanisms mediating the development of these acentric extrachromosomal elements have not been completely defined. To elucidate the mechanisms involved in DM formation, we have developed strategies to map amplified circular DM DNA. In this study, we present a long-range restriction map of a 980-kb DM. A cell line cloned from mouse EMT-6 cells was developed by stepwise selection for resistance to methotrexate. This cloned cell line contains multiple copies of the 980-kb DM carrying the dihydrofolate reductase (DHFR) gene. A long-range restriction map was developed in which a hypomethylated CpG-rich region near the DHFR gene served as a landmark. This strategy was combined with plasmid-like analysis of ethidium bromide-stained pulsed-field gels and indicated that a single copy of the DHFR gene was located near a hypomethylated region containing SsII and NotI sites. At least 490 kb of this DM appears to be composed of unrearranged chromosomal DNA.

scholarly journals The Genomic Geography and Evolution of Clusters of Tandemly Duplicated Genes in the Human and Mammal Genomes

2018 ◽  
Author(s):  
Juan F Ortiz ◽  
Antonis Rokas
Keyword(s):  
Human Chromosome ◽  
Olfactory Receptors ◽  
Gene Families ◽  
Pathogen Resistance ◽  
Duplicated Genes ◽  
Chromosome 19 ◽  
Fusion Event ◽  
Origin And Evolution ◽  
Mammalian Genomes ◽  
Human Chromosome 19

Clusters of duplicated genes (CTDGs) are nearly ubiquitous in life's genomes, and are associated with several well-known gene families, such as olfactory receptors, zinc fingers, and immunity-related genes, as well as with several highly variable traits, including olfaction, body plan architecture, and pathogen resistance. However, these observations are usually anecdotal, restricted to specific cases, and lacking evolutionary context. In this study, we use a robust statistical approach to characterize the CTDG repertoire and analyze the distribution of CTDGs across 18 mammal genomes, including human. We found that, on average, 18% of the genes in each species are parts of CTDGs. Although genes in CTDGs are enriched for several biological processes, these tend to be involved in the interactions between the organism and its environment. We further found that mammalian CTDGs are not uniformly distributed across chromosomes and that orthologs of the human chromosome 19 are among the most clustered chromosomes in nearly all mammalian genomes analyzed. We also found evidence that the human chromosome 19 was formed by a fusion event that occurred before the diversification of the rodent and primate lineages and maintained its high density of CTDGs during its subsequent evolution. Finally, using chromosome-level alignments across mammalian genomes, we show how the syntenic regions of the human chromosome 19 have been shrinking, increasing their gene density and possibly increasing the compactness of its CTDGs. These results suggest that CTDGs are a major feature of mammalian genomes and provide novel insights into the origin and evolution of regions with unusually high densities of CTDGs.

CpG island mapping of a mouse double-minute chromosome

1993 ◽  
Vol 13 (8) ◽  
pp. 4459-4464
Author(s):  
J L Beland ◽  
J A Longo ◽  
P J Hahn
Keyword(s):  
Cell Line ◽  
Long Range ◽  
Molecular Mechanisms ◽  
Cpg Island ◽  
Single Copy ◽  
Restriction Map ◽  
Chromosomal Dna ◽  
Dhfr Gene ◽  
Range Restriction ◽  
Double Minute

The development of double-minute chromosomes (DMs) and subsequent gene amplification are important genomic alterations resulting in increased oncogene expression in a variety of tumors. The molecular mechanisms mediating the development of these acentric extrachromosomal elements have not been completely defined. To elucidate the mechanisms involved in DM formation, we have developed strategies to map amplified circular DM DNA. In this study, we present a long-range restriction map of a 980-kb DM. A cell line cloned from mouse EMT-6 cells was developed by stepwise selection for resistance to methotrexate. This cloned cell line contains multiple copies of the 980-kb DM carrying the dihydrofolate reductase (DHFR) gene. A long-range restriction map was developed in which a hypomethylated CpG-rich region near the DHFR gene served as a landmark. This strategy was combined with plasmid-like analysis of ethidium bromide-stained pulsed-field gels and indicated that a single copy of the DHFR gene was located near a hypomethylated region containing SsII and NotI sites. At least 490 kb of this DM appears to be composed of unrearranged chromosomal DNA.

A Quantitative Trait Locus Influencing Activin-to-Estrogen Ratio in Pedigreed Baboons Maps to a Region Homologous to Human Chromosome 19

Human Biology ◽  
2001 ◽  
Vol 73 (6) ◽  
pp. 787-800 ◽  
Author(s):  
Lisa J. Martin ◽  
John Blangero ◽  
Jeffrey Rogers ◽  
Michael C. Mahaney ◽  
James E. Hixson ◽  
...  
Keyword(s):  
Quantitative Trait Locus ◽  
Human Chromosome ◽  
Quantitative Trait ◽  
Chromosome 19 ◽  
Trait Locus ◽  
Human Chromosome 19
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