Frequency of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by cocultivation with normal cells

1979 ◽  
Vol 46 (3) ◽  
pp. 331-334 ◽  
Author(s):  
C. R. Bartram ◽  
H. W. R�diger ◽  
E. Passarge
Keyword(s):  
Sister Chromatid ◽  
Bloom Syndrome ◽  
Sister Chromatid Exchanges ◽  
Normal Cells ◽  
Chromatid Exchanges

Single and twin sister chromatid exchanges in endoreduplicated Bloom Syndrome cells.

1982 ◽  
Vol 58 (8) ◽  
pp. 260-264 ◽  
Author(s):  
Yukimasa SHIRAISHI ◽  
Tosihide H. YOSIDA ◽  
Avery A. SANDBERG
Keyword(s):  
Sister Chromatid ◽  
Bloom Syndrome ◽  
Sister Chromatid Exchanges ◽  
Twin Sister ◽  
Chromatid Exchanges

scholarly journals The DNA Helicase Activity of BLM Is Necessary for the Correction of the Genomic Instability of Bloom Syndrome Cells

1999 ◽  
Vol 10 (3) ◽  
pp. 665-676 ◽  
Author(s):  
Norma F. Neff ◽  
Nathan A. Ellis ◽  
Tian Zhang Ye ◽  
James Noonan ◽  
Kelly Huang ◽  
...  
Keyword(s):  
Genomic Instability ◽  
Nuclear Localization ◽  
Sister Chromatid ◽  
Autosomal Recessive ◽  
Autosomal Recessive Disorder ◽  
Bloom Syndrome ◽  
Dna Helicase ◽  
Sister Chromatid Exchanges ◽  
Growth Deficiency ◽  
Chromatid Exchanges

Bloom syndrome (BS) is a rare autosomal recessive disorder characterized by growth deficiency, immunodeficiency, genomic instability, and the early development of cancers of many types. BLM, the protein encoded by BLM, the gene mutated in BS, is localized in nuclear foci and absent from BS cells. BLMencodes a DNA helicase, and proteins from three missense alleles lack displacement activity. BLM transfected into BS cells reduces the frequency of sister chromatid exchanges and restores BLM in the nucleus. Missense alleles fail to reduce the sister chromatid exchanges in transfected BS cells or restore the normal nuclear pattern. BLM complements a phenotype of aSaccharomyces cerevisiae sgs1 top3 strain, and the missense alleles do not. This work demonstrates the importance of the enzymatic activity of BLM for its function and nuclear localization pattern.

Effect of poly(ADP-ribose)polymerase inhibitors on the frequency of sister-chromatid exchanges in Bloom syndrome cells

1983 ◽  
Vol 122 (2) ◽  
pp. 223-228 ◽  
Author(s):  
Yukimasa Shiraishi ◽  
Yuko Tanaka ◽  
Mieko Kato ◽  
Masanao Miwa ◽  
Takashi Sugimura
Keyword(s):  
Sister Chromatid ◽  
Bloom Syndrome ◽  
Sister Chromatid Exchanges ◽  
Polymerase Inhibitors ◽  
Chromatid Exchanges
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