Isolation of probes detecting restriction fragment length polymorphisms from X chromosome-specific libraries: potential use for diagnosis of Duchenne muscular dystrophy

1985 ◽  
Vol 70 (2) ◽  
pp. 148-156 ◽  
Author(s):  
M. H. Hofker ◽  
M. C. Wapenaar ◽  
Nicole Goor ◽  
E. Bakker ◽  
G. -J. B. van Ommen ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
X Chromosome ◽  
Restriction Fragment ◽  
Fragment Length ◽  
Restriction Fragment Length Polymorphisms ◽  
Length Polymorphisms ◽  
Potential Use ◽  
Restriction Fragment Length

Isolation and characterization of DNA probes from the short arm of the human X chromosome that detect restriction fragment length polymorphisms

Genome ◽  
1987 ◽  
Vol 29 (1) ◽  
pp. 201-205 ◽  
Author(s):  
Terence Starr ◽  
Stephen Wood
Keyword(s):  
X Chromosome ◽  
Restriction Fragment ◽  
Fragment Length ◽  
Restriction Fragment Length Polymorphisms ◽  
Somatic Cell Hybrids ◽  
Key Words Dna ◽  
Isolation And Characterization ◽  
Length Polymorphisms ◽  
Restriction Fragment Length

We have isolated 30 X chromosome specific probes from a flow-sorted library enriched for the human X chromosome. Hybridization to somatic cell hybrids containing different regions of the X chromosome localized nine of these probes to Xp. After testing 185 probe–enzyme combinations, three of the Xp probes were found to detect restriction fragment length polymorphisms. Key words: DNA probe, polymorphisms (restriction), X chromosome.

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