An immunohistochemical study of localization of type I and type II collagens in mandibular condylar cartilage compared with tibial growth plate

1990 ◽  
Vol 93 (6) ◽  
pp. 593-599 ◽  
Author(s):  
I. Mizoguchi ◽  
M. Nakamura ◽  
I. Takahashi ◽  
M. Kagayama ◽  
H. Mitani
Keyword(s):  
Growth Plate ◽  
Immunohistochemical Study ◽  
Type I ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Mandibular Condylar Cartilage ◽  
Tibial Growth Plate

An immunohistochemical study of regional differences in the distribution of type I and type II collagens in rat mandibular condylar cartilage

1996 ◽  
Vol 41 (8-9) ◽  
pp. 863-869 ◽  
Author(s):  
Itaru Mizoguchi ◽  
Ichiro Takahashi ◽  
Masanori Nakamura ◽  
Yasuyuki Sasano ◽  
Seiji Sato ◽  
...  
Keyword(s):  
Regional Differences ◽  
Immunohistochemical Study ◽  
Type I ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Mandibular Condylar Cartilage

Immunohistochemical findings type I and type II collagen in prenatal mouse mandibular condylar cartilage compared with the tibial anlage

1998 ◽  
Vol 43 (7) ◽  
pp. 545-550 ◽  
Author(s):  
Masako Ishii ◽  
Naoto Suda ◽  
Toshimoto Tengan ◽  
Shoichi Suzuki ◽  
Takayuki Kuroda
Keyword(s):  
Type Ii Collagen ◽  
Type I ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Mandibular Condylar Cartilage

Changes in Type I and Type II Collagen Expression in Rat Mandibular Condylar Cartilage Associated with Aging and Dietary Loading

2018 ◽  
Vol 32 (3) ◽  
pp. 258-265 ◽  
Author(s):  
Marko Orajärvi ◽  
Sakari Laaksonen ◽  
Riikka Hauru ◽  
Eerika Mursu ◽  
Egle Jonaviciute ◽  
...  
Keyword(s):  
Type Ii Collagen ◽  
Type I ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Collagen Expression ◽  
Mandibular Condylar Cartilage

Type II collagen and TGF-βs in developing and aging porcine mandibular condylar cartilage: immunohistochemical studies

1997 ◽  
Vol 289 (1) ◽  
pp. 119-124 ◽  
Author(s):  
J. R. Moroco ◽  
R. Hinton ◽  
P. Buschang ◽  
S. B. Milam ◽  
A. M. Iacopino
Keyword(s):  
Type Ii Collagen ◽  
Type Ii ◽  
Condylar Cartilage ◽  
Mandibular Condylar Cartilage ◽  
Immunohistochemical Studies

scholarly journals Expression of a Truncated, Kinase-Defective TGF-β Type II Receptor in Mouse Skeletal Tissue Promotes Terminal Chondrocyte Differentiation and Osteoarthritis

1997 ◽  
Vol 139 (2) ◽  
pp. 541-552 ◽  
Author(s):  
Rosa Serra ◽  
Mahlon Johnson ◽  
Ellen H. Filvaroff ◽  
James LaBorde ◽  
Daniel M. Sheehan ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Transgenic Mice ◽  
Growth Plate ◽  
Dominant Negative Mutant ◽  
Type I ◽  
Type Ii ◽  
Type X Collagen ◽  
Skeletal Tissue ◽  
Hypertrophic Cartilage ◽  
Growth Plate Cartilage

Members of the TGF-β superfamily are important regulators of skeletal development. TGF-βs signal through heteromeric type I and type II receptor serine/threonine kinases. When over-expressed, a cytoplasmically truncated type II receptor can compete with the endogenous receptors for complex formation, thereby acting as a dominant-negative mutant (DNIIR). To determine the role of TGF-βs in the development and maintenance of the skeleton, we have generated transgenic mice (MT-DNIIR-4 and -27) that express the DNIIR in skeletal tissue. DNIIR mRNA expression was localized to the periosteum/perichondrium, syno-vium, and articular cartilage. Lower levels of DNIIR mRNA were detected in growth plate cartilage. Transgenic mice frequently showed bifurcation of the xiphoid process and sternum. They also developed progressive skeletal degeneration, resulting by 4 to 8 mo of age in kyphoscoliosis and stiff and torqued joints. The histology of affected joints strongly resembled human osteo-arthritis. The articular surface was replaced by bone or hypertrophic cartilage as judged by the expression of type X collagen, a marker of hypertrophic cartilage normally absent from articular cartilage. The synovium was hyperplastic, and cartilaginous metaplasia was observed in the joint space. We then tested the hypothesis that TGF-β is required for normal differentiation of cartilage in vivo. By 4 and 8 wk of age, the level of type X collagen was increased in growth plate cartilage of transgenic mice relative to wild-type controls. Less proteoglycan staining was detected in the growth plate and articular cartilage matrix of transgenic mice. Mice that express DNIIR in skeletal tissue also demonstrated increased Indian hedgehog (IHH) expression. IHH is a secreted protein that is expressed in chondrocytes that are committed to becoming hypertrophic. It is thought to be involved in a feedback loop that signals through the periosteum/ perichondrium to inhibit cartilage differentiation. The data suggest that TGF-β may be critical for multifaceted maintenance of synovial joints. Loss of responsiveness to TGF-β promotes chondrocyte terminal differentiation and results in development of degenerative joint disease resembling osteoarthritis in humans.

Does high-grade endometrioid carcinoma (grade 3 FIGO) belong to type I or type II endometrial cancer? A clinical–pathological and immunohistochemical study

2010 ◽  
Vol 457 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Gian Franco Zannoni ◽  
Valerio Gaetano Vellone ◽  
Vincenzo Arena ◽  
Maria Grazia Prisco ◽  
Giovanni Scambia ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Immunohistochemical Study ◽  
Type I ◽  
High Grade ◽  
Type Ii ◽  
Endometrioid Carcinoma ◽  
Grade 3
Sign in / Sign up

Export Citation Format

Share Document