Physiologic tomography: A new means for the non-invasive measurement of myocardial metabolism, blood flow and function

1980 ◽  
Vol 5 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Heinrich R. Schelbert ◽  
Michael E. Phelps
Keyword(s):  
Blood Flow ◽  
Myocardial Metabolism ◽  
Non Invasive ◽  
And Function ◽  
Invasive Measurement

scholarly journals Quantitative blood flow measurement in rat brain with multiphase arterial spin labelling magnetic resonance imaging

2018 ◽  
Vol 39 (8) ◽  
pp. 1557-1569 ◽  
Author(s):  
James R Larkin ◽  
Manon A Simard ◽  
Alexandre A Khrapitchev ◽  
James A Meakin ◽  
Thomas W Okell ◽  
...  
Keyword(s):  
Blood Flow ◽  
Flow Measurement ◽  
Arterial Spin Labelling ◽  
Sprague Dawley ◽  
Functional Studies ◽  
Non Invasive ◽  
Disease States ◽  
Preclinical Mri ◽  
Invasive Measurement ◽  
Spin Labelling

Cerebral blood flow is an important parameter in many diseases and functional studies that can be accurately measured in humans using arterial spin labelling (ASL) MRI. However, although rat models are frequently used for preclinical studies of both human disease and brain function, rat CBF measurements show poor consistency between studies. This lack of reproducibility is due, partly, to the smaller size and differing head geometry of rats compared to humans, as well as the differing analysis methodologies employed and higher field strengths used for preclinical MRI. To address these issues, we have implemented, optimised and validated a multiphase pseudo-continuous ASL technique, which overcomes many of the limitations of rat CBF measurement. Three rat strains (Wistar, Sprague Dawley and Berlin Druckrey IX) were used, and CBF values validated against gold-standard autoradiography measurements. Label positioning was found to be optimal at 45°, while post-label delay was optimised to 0.55 s. Whole brain CBF measures were 109 ± 22, 111 ± 18 and 100 ± 15 mL/100 g/min by multiphase pCASL, and 108 ± 12, 116 ± 14 and 122 ± 16 mL/100 g/min by autoradiography in Wistar, SD and BDIX cohorts, respectively. Tumour model analysis shows that the developed methods also apply in disease states. Thus, optimised multiphase pCASL provides robust, reproducible and non-invasive measurement of CBF in rats.

In Vitro Simulation of the First Technique for Non-Invasive Measurement of Volumetric Ophthalmic Artery Blood Flow in Humans

2010 ◽  
Vol 41 (3) ◽  
pp. 375-382 ◽  
Author(s):  
Brent Siesky ◽  
Alon Harris ◽  
Larry Kagemann ◽  
Danny Moore ◽  
Adam Werne ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ophthalmic Artery ◽  
Artery Blood Flow ◽  
Non Invasive ◽  
In Vitro Simulation ◽  
Invasive Measurement

Portal blood flow in acute hepatitis with and without ascites: A non-invasive measurement using an ultrasonic Doppler

1995 ◽  
Vol 10 (1) ◽  
pp. 36-41 ◽  
Author(s):  
SIEN-SING YANG ◽  
CHI-HWA WU ◽  
TZEN-KWAN CHEN ◽  
CHIA-LONG LEE ◽  
YUNG-CHIH LAI ◽  
...  
Keyword(s):  
Blood Flow ◽  
Acute Hepatitis ◽  
Portal Blood Flow ◽  
Portal Blood ◽  
Non Invasive ◽  
Invasive Measurement
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