The effect of posterior spinal fixation with acrylic cement on the vertebral growth plate and intervertebral disc in dogs

1986 ◽  
Vol 10 (1) ◽  
Author(s):  
Myung-Sang Moon ◽  
In-Young Ok ◽  
Kee-Yong Ha
Keyword(s):  
Intervertebral Disc ◽  
Growth Plate ◽  
Spinal Fixation ◽  
Acrylic Cement ◽  
Vertebral Growth

Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc

2019 ◽  
Vol 476 (2) ◽  
pp. 225-243 ◽  
Author(s):  
Cindy C. Shu ◽  
Susan M. Smith ◽  
Christopher B. Little ◽  
James Melrose
Keyword(s):  
Extracellular Matrix ◽  
Intervertebral Disc ◽  
Growth Plate ◽  
Intervertebral Discs ◽  
Tissue Homeostasis ◽  
Disc Cell ◽  
Null Mouse ◽  
Growth Plates ◽  
Matrix Deposition ◽  
Vertebral Growth

Abstract Heparan sulfate (HS) regulates diverse cell signalling events in intervertebral disc development and homeostasis. The aim of the present study was to investigate the effect of ablation of perlecan HS/CS on murine intervertebral disc development. Genetic models carrying mutations in genes encoding HS biosynthetic enzymes have identified multiple roles for HS in tissue homeostasis. In the present study, we utilised an Hspg2 exon 3 null HS/CS-deficient mouse to assess the role of perlecan HS in disc cell regulation. HS makes many important contributions to growth factor sequestration, stabilisation/delivery, and activation of receptors directing cellular proliferation, differentiation, and assembly of extracellular matrix. Perlecan HS/CS-mediated interactions promote extracellular matrix assembly/stabilisation and tissue functional properties, and thus, removal of perlecan HS/CS should affect extracellular matrix function and homeostasis. Hspg2 exon 3 null intervertebral discs accumulated significantly greater glycosaminoglycan in the nucleus pulposus, annulus fibrosus, and vertebral growth plates than C57BL/6 wild-type (WT) I intervertebral discs. Proliferation of intervertebral disc progenitor cells was significantly higher in Hspg2 exon 3 null intervertebral discs, and these cells became hypertrophic by 12 weeks of age and were prominent in the vertebral growth plates but had a disorganised organisation. C57BL/6 WT vertebral growth plates contained regular columnar growth plate chondrocytes. Exostosis-like, ectopic bone formation occurred in Hspg2 exon 3 null intervertebral discs, and differences were evident in disc cell maturation and in matrix deposition in this genotype, indicating that perlecan HS/CS chains had cell and matrix interactive properties which repressively maintained tissue homeostasis in the adult intervertebral disc.

P5. Experimental study on the expression of growth factors in the vertebral growth plate and pedicle in severe idiopathic scoliosis

2019 ◽  
Vol 19 (9) ◽  
pp. S160
Author(s):  
Tao Li ◽  
Yingsong Wang ◽  
Jing-Ming Xie ◽  
Zhiyue Shi ◽  
Quan Li ◽  
...  
Keyword(s):  
Experimental Study ◽  
Growth Factors ◽  
Idiopathic Scoliosis ◽  
Growth Plate ◽  
Vertebral Growth

Expression of Runx2 and Type X Collagen in Vertebral Growth Plate of Patients with Adolescent Idiopathic Scoliosis

2010 ◽  
Vol 51 (3) ◽  
pp. 188-196 ◽  
Author(s):  
Shoufeng Wang ◽  
Yong Qiu ◽  
Zhaolong Ma ◽  
Caiwei Xia ◽  
Feng Zhu ◽  
...  
Keyword(s):  
Adolescent Idiopathic Scoliosis ◽  
Idiopathic Scoliosis ◽  
Growth Plate ◽  
Type X Collagen ◽  
Vertebral Growth

scholarly journals Persistence of vertebral growth plate cartilage in aged cynomolgus monkeys

2018 ◽  
Vol 31 (2) ◽  
pp. 151-154 ◽  
Author(s):  
Munetaka Iwata ◽  
Wataru Yamamoto ◽  
Takasumi Shimomoto ◽  
Yuki Okada ◽  
Satomi Oosawa ◽  
...  
Keyword(s):  
Growth Plate ◽  
Cynomolgus Monkeys ◽  
Growth Plate Cartilage ◽  
Vertebral Growth
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