scholarly journals Limitations of capillary plasma immunoreactive insulin assay as an epidemiological tool

Diabetologia ◽  
1989 ◽  
Vol 32 (5) ◽  
pp. 329-329 ◽  
Author(s):  
D. Simmons ◽  
H. Dhar ◽  
T. D. R. Hockaday
Keyword(s):  
Immunoreactive Insulin ◽  
Epidemiological Tool ◽  
Plasma Immunoreactive Insulin

Effects of selective insulin or glucagon deficiency on glucose turnover.

1979 ◽  
Vol 236 (3) ◽  
pp. E255
Author(s):  
H L Lickley ◽  
G G Ross ◽  
M Vranic
Keyword(s):  
Glucose Production ◽  
Plasma Free Fatty Acid ◽  
Metabolic Effects ◽  
Glucose Turnover ◽  
Immunoreactive Insulin ◽  
Hormonal Changes ◽  
Futile Cycling ◽  
Plasma Immunoreactive Insulin ◽  
Glucagon Suppression ◽  
Glucagon And Insulin

To study the importance of glucagon and insulin in diabetes, somatostatin (ST) was infused, alone or with insulin or glucagon, in 11 conscious dogs. Plasma immunoreactive insulin (IRI) and glucagon (IRG) levels fell 65 +/- 4% and 33 +/- 3%, respectively, with somatostatin infusion. Glucose production (Ra) assessed by [3-3H]glucose, [2-3H]glucose, or [1-14C]glucose decreased transiently. This is in contrast to the rise in Ra seen after insulin withdrawal in depancreatized dogs, which have normal levels of IRG. Thus, suppression of IRG with somatostatin prevented an increase in Ra in spite of suppression of IRI. When near basal IRG levels were provided during ST infusion in normal dogs, Ra increased, indicating that glucagon contributes to the acute development of diabetes. When basal IRI levels were provided with ST, suppression of Ra was maintained, suggesting that the transience of the metabolic effects of ST-induced glucagon suppression requires concomitant insulin suppression. A comparison of glucose turnover measured using different tracers showed that ST-related hormonal changes did not alter the rate of futile cycling in the liver. ST induced a rise in plasma free fatty acid (FFA) levels, attributed solely to insulin deficiency, as glucagon suppression did not significantly alter FFA concentrations when normal insulin levels were maintained.

scholarly journals Effect of dietary proteins on the plasma immunoreactive insulin-like growth factor-1/somatomedin C concentration in the rat

1990 ◽  
Vol 63 (3) ◽  
pp. 521-534 ◽  
Author(s):  
Sachiko Takahashi ◽  
Mikio Kajikawa ◽  
Tsutomu Umezawa ◽  
Shin-Ichiro Takahashi ◽  
Hisanorl Kato ◽  
...  
Keyword(s):  
Growth Factor ◽  
Immunoreactive Insulin ◽  
Dietary Proteins ◽  
Insulin Like Growth Factor ◽  
Somatomedin C ◽  
Plasma Immunoreactive Insulin

GROWTH HORMONE RELATED TO INSULIN AND SUGAR IN NOCTURNAL BLOOD PLASMA OF LACTATING COWS

1976 ◽  
Vol 82 (4) ◽  
pp. 767-773 ◽  
Author(s):  
K. Halse ◽  
Anne Kristine Blom ◽  
K. Hove
Keyword(s):  
Growth Hormone ◽  
Blood Plasma ◽  
Immunoreactive Insulin ◽  
Plasma Samples ◽  
Plasma Growth Hormone ◽  
Lactating Cows ◽  
High Insulin ◽  
Plasma Immunoreactive Insulin ◽  
Correlation Tests ◽  
Lactation Cycle

ABSTRACT Nocturnal blood plasma samples from about 190 indoor-fed cows at varying stages of the lactation cycle showed wide variations in the concentrations of sugar (43–88 mg/100 ml) and acetoacetate (0.12–8.7 mg/100 ml). Plasma immunoreactive insulin decreased and acetoacetate increased with decreasing sugar. Plasma growth hormone (GH) was significantly correlated to insulin (r = −0.24, P < 0.001) and to sugar (r = −0.15, P < 0.05), but not to acetoacetate (r = +0.13). Since the plasma level of GH in bovines is known to vary widely from hour to hour, individual cows are poorly represented by single determinations of the hormone. However, in accordance with the results from the correlation tests, different GH averages, about 11 and 9 ng/ml, were found for groups of animals with plasma sugar respectively below and above 70 mg/100 ml. By subgrouping according to insulin levels within sugar ranges, categories could be singled out with GH averages as different as 12.7 ng/ml (low sugar - low insulin) and 8.3 ng/ml (high sugar - high insulin). The findings are consistent with the view that GH is involved in the regulation of energy metabolism in bovines. But no support has been provided for the hypothesis of GH hypersecretion as a cause of ketosis in cows.

CHANGES IN PLASMA GROWTH HORMONE AND INSULIN OF THE HUMAN FOETUS FOLLOWING HYSTEROTOMY

1971 ◽  
Vol 66 (4) ◽  
pp. 577-586 ◽  
Author(s):  
R. C. Turner ◽  
B. Schneeloch ◽  
P. Paterson
Keyword(s):  
Growth Hormone ◽  
Plasma Insulin ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Immunoreactive Insulin ◽  
Plasma Growth Hormone ◽  
Plasma Insulin Concentration ◽  
Plasma Immunoreactive Insulin ◽  
The Mean ◽  
Serial Samples

ABSTRACT Plasma immunoreactive insulin and growth hormone of 20–24 weeks' gestation human foetuses were assayed in serial samples following delivery by hysterotomy. The mean umbilical cord plasma growth hormone concentration was 71 ng/ml (range 13–120 ng/ml) and the mean plasma insulin was 5 μU/ml (range 2–8 μU/ml). Following delivery the growth hormone levels increased, but there was no significant change in plasma insulin concentration. The hypothalamic-hypophyseal axis controlling growth hormone secretion appears to be developed by 20 weeks' gestation, and »stress« appears to be a provocative stimulus.

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