Flow cytometric analysis of cellular DNA in human prostate cancer: relationship to 5?-reductase activity of the tissue

1989 ◽  
Vol 17 (4) ◽  
Author(s):  
F.K. Habib ◽  
A. Bissas ◽  
W.A. Neill ◽  
A. Busuttil ◽  
G.D. Chisholm
Keyword(s):  
Prostate Cancer ◽  
Reductase Activity ◽  
Flow Cytometric Analysis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Flow Cytometric ◽  
Cellular Dna

Cellular DNA content and proliferative index as markers in human prostate cancer

1987 ◽  
Vol 23 (8) ◽  
pp. 1237
Author(s):  
R. De Vita ◽  
D. Forte ◽  
F. Maggi ◽  
R. Tenaglia ◽  
F. Di Silverio
Keyword(s):  
Prostate Cancer ◽  
Dna Content ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Proliferative Index ◽  
Cellular Dna

scholarly journals Schistosoma Egg Antigen Induces Oncogenic Alterations in Human Prostate Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Isaac Tuffour ◽  
Irene Ayi ◽  
Theresa Manful Gwira ◽  
Edward Dumashie ◽  
Yvonne Ashong ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Flow Cytometric Analysis ◽  
Urine Samples ◽  
Human Prostate ◽  
Prostate Cell ◽  
Prostate Cells ◽  
Flow Cytometric ◽  
Egg Antigen ◽  
Excessive Proliferation

Schistosomiasis is a neglected tropical disease that affects 200 million people and accounts for 100,000 deaths annually. In endemic geographical areas, schistosomiasis has been implicated as an etiological agent in the pathogenesis of bladder, colorectal, and renal carcinoma largely due to Schistosoma eggs in tissues that comes with chronic infection. Several studies have also reported cases of association between Schistosoma infection and prostate cancer. The possible causal association is however poorly understood. We hypothesized in this study that infection of the prostate cells with Schistosoma spp promotes cancer. Urine samples from individuals living in Galilea, a schistosomiasis endemic community in the Ga South District of Ghana, were collected and screened for Schistosoma infection via microscopy and multiplex PCR. Soluble egg antigens (SEA) were prepared from Schistosoma egg-positive urine samples and assessed for the ability to induce cancer-like phenotypes including excessive proliferation, oxidative stress (reduced glutathione (GSH) depletion), and diminished apoptosis in cultured human prostate (PNT2) cells. Molecular analysis revealed infecting schistosome species to be S. haematobium and S. mansoni. Prostate cell proliferation was significantly induced by 12.5 μg/ml SEA (p=0.029). Also, SEA dose-dependently depleted cellular GSH. Flow cytometric analysis and fluorescence staining revealed that SEA dose-dependently diminished apoptosis, significantly, in prostate cells. Findings of this study suggest that schistosome infection may play a role in the pathogenesis of prostate cancer. In vivo studies are however needed to confirm this association.

629: Novel Laser Activated Gold Nanoshell Thermal Ablation of Human Prostate Cancer in Vivo

2007 ◽  
Vol 177 (4S) ◽  
pp. 210-211 ◽  
Author(s):  
Joshua M. Stern ◽  
Jennifer Stanfield ◽  
Jer-Tsang Hsieh ◽  
Jeffrey A. Cadeddu
Keyword(s):  
Prostate Cancer ◽  
Thermal Ablation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Gold Nanoshell

1495: Elevated Expression of Tumor-Associated Macrophages is Associated with Poor Prognosis of Human Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 483-483
Author(s):  
Hitoshi Takayama ◽  
Norio Nonomura ◽  
Daizo Oka ◽  
Masahiro Shiba ◽  
Yasuyuki Arai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Poor Prognosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Tumor Associated Macrophages ◽  
Elevated Expression

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines
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