Comparative analysis of short-term and long-term prophylactic intravesical chemotherapy of superficial bladder cancer

1987 ◽  
Vol 20 (S1) ◽  
Author(s):  
Hideyuki Akaza ◽  
Shigeo Isaka ◽  
Kenkichi Koiso ◽  
Toshihiko Kotake ◽  
Toyohei Machida ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Comparative Analysis ◽  
Superficial Bladder Cancer ◽  
Intravesical Chemotherapy ◽  
Short Term

scholarly journals Analysis of Japanese Patients Treated with or without Long-Term Epirubicin Plus Ara-C Intravesical Instillation Therapy for Low-Grade Superficial Bladder Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Tomonori Kato ◽  
Kazushi Nomura ◽  
Fukuo Kondo ◽  
Masami Wakisaka ◽  
Akira Komiya
Keyword(s):  
Bladder Cancer ◽  
Tumor Recurrence ◽  
Superficial Bladder Cancer ◽  
Transitional Cell ◽  
Japanese Patients ◽  
Intravesical Instillation ◽  
Intravesical Chemotherapy ◽  
Low Grade ◽  
Free Rate

The high incidence of tumor recurrence following transurethral resection (TUR) represents a major problem encountered in the management of bladder cancer. This study examined the efficacy of intravesical chemotherapy in superficial bladder cancer. We retrospectively analyzed 90 Japanese cases with low-grade superficial transitional cell carcinoma (stage T1, grades 1 and 2) who were rendered tumor-free by TURBT (TUR of bladder tumor) and who thereafter were treated with or without intravesical chemotherapy. Among them, instillation was terminated in 2 patients due to adverse effects (severe but reversible chemical cystitis). Remaining 88 patients were divided into 2 groups according to therapy: the TURBT-only group(n=46), defined as patients treated with TURBT alone, and the Instillation group(n=42), defined as patients treated with weekly intravesical instillation therapies using epirubicin plus Ara-C. Recurrence-free rate was significantly higher in the Instillation group than in the TURBT-only group (p=0.02, HR = 0.457). The 5-year recurrence-free rate was 58.5% for the Instillation group and 38.6% for the TURBT-only group. Our instillation schedule represents the most intensive regimen among previously reported therapies and resulted in a 54.3% decrease in incidence of tumor recurrence. We believe that the results of this study could provide useful information on management of bladder cancer.

Short Schedule Intravesical Mitomycin Preceding Transurethral Resection for Recurrent Ta-T1, G1-G2 Bladder Cancer

1995 ◽  
Vol 81 (3) ◽  
pp. 191-193
Author(s):  
Massimo Maffezzini ◽  
Alchiede Simonato ◽  
Cristina Lodolo ◽  
Marco Raber ◽  
Giorgio Carmignani
Keyword(s):  
Bladder Cancer ◽  
Transurethral Resection ◽  
Small Volume ◽  
Superficial Bladder Cancer ◽  
Residual Disease ◽  
Intravesical Chemotherapy ◽  
Number Of Patients ◽  
Intravesical Instillations ◽  
Short Schedule

Aims and Background Intravesical instillations commonly follow resection, when all visible lesions have been removed, making impossible any direct assessment of efficacy. The study was conceived to evaluate the ablative effect on the tumor and the efficacy in reducing the risk of recurrence of short schedule intravesical chemotherapy administered before endoscopic resection. Study design Four weekly intravesical instillations of mitomycin C followed by transurethral resection (TUR) were administered to 31 patients with recurrent small volume superficial bladder cancer. Results At TUR no evidence of disease was found in 22 patients (70.9%) and residual disease in the remaining 9 (29.1%). At a median follow-up of 15 months (range, 3-33) 16 of 31 patients (51.6%) had recurrence of disease. The treatment was well tolerated. Conclusions Short-schedule intravesical chemotherapy can completely ablate small volume recurrent superficial bladder cancer in a relevant number of patients but is probably not sufficient to obtain long-term prophylaxis.

832: Optimized Intravesical Mitomycin C Treatment for Superficial Bladder Cancer: Long-Term Follow-Up

2006 ◽  
Vol 175 (4S) ◽  
pp. 268-269 ◽  
Author(s):  
Jessie L. Au ◽  
Robert A. Badalament ◽  
M. Guillaume Wientjes ◽  
Donn C. Young ◽  
Tong Shen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mitomycin C ◽  
Superficial Bladder Cancer ◽  
Long Term Follow Up

Results of Transurethral Resection Plus Adjuvant Intravesical Chemotherapy for Superficial Bladder Cancer

1998 ◽  
Vol 5 (6) ◽  
pp. 534-539 ◽  
Author(s):  
Masashi Nomi ◽  
Kazuo Gohji ◽  
Masayuki Okamoto ◽  
Atsushi Takenaka ◽  
Yoshiharu Ono ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Transurethral Resection ◽  
Superficial Bladder Cancer ◽  
Intravesical Chemotherapy

scholarly journals COMPARATIVE ANALYSIS OF LOW TEMPERATURE RESISTANCE FOR NANOCARBON AND OTHER BITUMENS

2020 ◽  
Vol 5 (443) ◽  
pp. 89-96
Author(s):  
Zhurinov M.Zh., ◽  
◽  
Teltayev B.B., ◽  
Kalybay A.A., ◽  
Rossi C.O., ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Low Temperature ◽  
Polyphosphoric Acid ◽  
Crumb Rubber ◽  
Petrochemical Plant ◽  
Short Term ◽  
Temperature Resistance ◽  
Coal Rock ◽  
Low Temperature Resistance

A comparative analysis of the low temperature resistance for a nanocarbon bitumen and other 30 neat and modified bitumens has been performed in the work. The stiffness at the temperatures of -24°С, -30°С and -36°С under technical system Superpave has been accepted as an indicator of low temperature resistance of the bitumens. The stiffness of the bitumens has been determined on a bending beam rheometer (standard ASTM D 6648-08). Before testing the bitumens have been subjected to the double artificial aging: short-term aging – under standard AASHTO Т 240-13 and long-term aging – under standard ASTM D 6521-08. The nanocarbon bitumen has been prepared in the laboratory of the Kazakhstan Highway Research Institute (KazdorNII) with the use of a road bitumen of the grade BND 70/100 produced by the Pavlodar petrochemical plant (PNHZ) and a nanocarbon powder (2% by weight) manufactured from a coal rock of the deposit “Saryadyr” “Corporation “ON-Olzha” LLP, Akmola region, Kazakhstan). The nanocarbon powder (150-200 nm) has been manufactured by three-stage size reduction of the coal rock: I – a mechanical dispergator (up to 2-3 mm), II – an aerodynamic mill (up to 20 mcm), III – a reactor with a rotating electromagnetic field. The neat bitumens of the grades BND 50/70, BND 70/100, BND 100/130 have been produced by the plants of Kazakhstan and Russia; they satisfy the requirements of the standard ST RK 1373-2013. The modified bitumens have been prepared in the laboratory of KazdorNII with the use of the neat bitumens, 7 types of the polymers, crumb rubber and polyphosphoric acid and they satisfy the requirements of the standard ST RK 2534-2014. It has been determined that the nanocarbon bitumen is one of the most resistant at the low temperatures: -24°С, -30°С and -36°С.

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