Selective decontamination of the digestive tract improves survival in patients receiving differential lung ventilation

1988 ◽  
Vol 15 (1) ◽  
pp. 15-18 ◽  
Author(s):  
D. F. Zandstra ◽  
Ch. P. Stoutenbeek ◽  
H. K. F. van Saene ◽  
J. L. Bams
Keyword(s):  
Digestive Tract ◽  
Lung Ventilation ◽  
Selective Decontamination ◽  
Differential Lung Ventilation

scholarly journals Selective Decontamination of the Digestive Tract to Prevent Postoperative Pneumonia and Anastomotic Leakage after Esophagectomy: A Retrospective Cohort Study

Antibiotics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 43
Author(s):  
Robin Janssen ◽  
Frans Van Workum ◽  
Nikolaj Baranov ◽  
Harmen Blok ◽  
Jaap ten Oever ◽  
...  
Keyword(s):  
Cohort Study ◽  
Anastomotic Leakage ◽  
Digestive Tract ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Protective Factor ◽  
Gastrointestinal Surgery ◽  
Surgical Site Infections ◽  
Selective Decontamination ◽  
Postoperative Pneumonia

Infectious complications occur frequently after esophagectomy. Selective decontamination of the digestive tract (SDD) has been shown to reduce postoperative infections and anastomotic leakage in gastrointestinal surgery, but robust evidence for esophageal surgery is lacking. The aim was to evaluate the association between SDD and pneumonia, surgical-site infections (SSIs), anastomotic leakage, and 1-year mortality after esophagectomy. A retrospective cohort study was conducted in patients undergoing Ivor Lewis esophagectomy in four Dutch hospitals between 2012 and 2018. Two hospitals used SDD perioperatively and two did not. SDD consisted of an oral paste and suspension (containing amphotericin B, colistin, and tobramycin). The primary outcomes were 30-day postoperative pneumonia and SSIs. Secondary outcomes were anastomotic leakage and 1-year mortality. Logistic regression analyses were performed to determine the association between SDD and the relevant outcomes (odds ratio (OR)). A total of 496 patients were included, of whom 179 received SDD perioperatively and the other 317 patients did not receive SDD. Patients who received SDD were less likely to develop postoperative pneumonia (20.1% vs. 36.9%, p < 0.001) and anastomotic leakage (10.6% vs. 19.9%, p = 0.008). Multivariate analysis showed that SDD is an independent protective factor for postoperative pneumonia (OR 0.40, 95% CI 0.23–0.67, p < 0.001) and anastomotic leakage (OR 0.46, 95% CI 0.26–0.84, p = 0.011). Use of perioperative SDD seems to be associated with a lower risk of pneumonia and anastomotic leakage after esophagectomy.

scholarly journals Statistical Analysis Plan for the Selective Decontamination of the Digestive Tract in Intensive Care Unit (SuDDICU) study

2020 ◽  
Author(s):  
Laurent Billot ◽  
John Myburgh ◽  
Fiona Goodman ◽  
Simon Finfer ◽  
Ian Seppelt ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Statistical Analysis ◽  
Digestive Tract ◽  
Controlled Trial ◽  
Cluster Randomised Controlled Trial ◽  
Statistical Analysis Plan ◽  
Selective Decontamination ◽  
Cluster Randomised ◽  
Randomised Controlled

SuDDICU is an international, multicentre, cross-over, cluster randomised controlled trial comparing the effect of selective decontamination of the digestive tract to usual care on hospital mortality in patients receiving mechanical ventilation in the intensive care unit. This manuscript presents the pre-specified statistical analysis plan (SAP) for the SuDDICU trial. The SAP was written without knowledge of the effect of the intervention.

Unique differential lung ventilation system

2006 ◽  
Vol 39 ◽  
pp. S589
Author(s):  
J. Glapiński ◽  
M. Darowski ◽  
A. Nestorowicz ◽  
M. Ston ◽  
M. Michnikowski ◽  
...  
Keyword(s):  
Ventilation System ◽  
Lung Ventilation ◽  
Differential Lung Ventilation

Cost-Effectiveness of Perioperative Selective Decontamination of the Digestive Tract versus Placebo in Elective Gastrointestinal Surgery

2012 ◽  
Vol 29 (5) ◽  
pp. 384-390 ◽  
Author(s):  
L.M. Dijksman ◽  
D. Roos ◽  
M.F. Gerhards ◽  
J.G.P. Tijssen ◽  
D.J. Gouma ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Digestive Tract ◽  
Gastrointestinal Surgery ◽  
Selective Decontamination

Selective decontamination of the digestive tract

1995 ◽  
Vol 8 (2) ◽  
pp. 114-118 ◽  
Author(s):  
Peter D. Potgieter ◽  
Janet M.J. Hammond
Keyword(s):  
Digestive Tract ◽  
Selective Decontamination
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