Antitumor activity of 3?, 5?-diesters of 5-fluoro-2?-deoxyuridine against murine leukemia L1210 cells

1981 ◽  
Vol 6 (1) ◽  
Author(s):  
Fumihiko Kanzawa ◽  
Akio Hoshi ◽  
Kazuo Kuretani ◽  
Mineo Saneyoshi ◽  
Takeo Kawaguchi
Keyword(s):  
Antitumor Activity ◽  
L1210 Cells ◽  
Murine Leukemia

scholarly journals Benzoyl Peroxide Increases UVA-Induced Plasma Membrane Damage and Lipid Oxidation in Murine Leukemia L1210 Cells

1998 ◽  
Vol 110 (1) ◽  
pp. 79-83 ◽  
Author(s):  
Sally H. Ibbotson ◽  
Christopher R. Lambert ◽  
Michael N. Moran ◽  
Mary C. Lynch ◽  
Irene E. Kochevar
Keyword(s):  
Plasma Membrane ◽  
Lipid Oxidation ◽  
Benzoyl Peroxide ◽  
Membrane Damage ◽  
Plasma Membrane Damage ◽  
L1210 Cells ◽  
Murine Leukemia

scholarly journals Solanum lyratumExtracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Jai-Sing Yang ◽  
Chia-Chun Wu ◽  
Chao-Lin Kuo ◽  
Yu-Hsuan Lan ◽  
Chin-Chung Yeh ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Fas Ligand ◽  
Leukemia Cells ◽  
Cycle Arrest ◽  
Phase Arrest ◽  
Apoptotic Pathways ◽  
Murine Leukemia

We investigated the molecular mechanisms of cell cycle arrest and apoptotic death induced bySolanum lyratumextracts (SLE) or diosgenin in WEHI-3 murine leukemia cellsin vitroand antitumor activityin vivo. Diosgenin is one of the components of SLE. Our study showed that SLE and diosgenin decreased the viable WEHI-3 cells and inducedG0/G1phase arrest and apoptosis in concentration- or time-dependent manners. Both reagents increased the levels of ROS production and decreased the mitochondrial membrane potential (ΔΨm). SLE- and diosgenin-triggered apoptosis is mediated through modulating the extrinsic and intrinsic signaling pathways. Intriguingly, the p53 inhibitor (pifithrin-α), anti-Fas ligand (FasL) mAb, and specific inhibitors of caspase-8 (z-IETD-fmk), caspase-9 (z-LEHD-fmk), and caspase-3 (z-DEVD-fmk) blocked SLE- and diosgenin-reduced cell viability of WEHI-3 cells. Thein vivostudy demonstrated that SLE has marked antitumor efficacy against tumors in the WEHI-3 cell allograft model. In conclusion, SLE- and diosgenin-inducedG0/G1phase arrest and triggered extrinsic and intrinsic apoptotic pathways via p53 activation in WEHI-3 cells. SLE also exhibited antitumor activityin vivo. Our findings showed that SLE may be potentially efficacious in the treatment of leukemia in the future.

scholarly journals Lectinocytochemical detection of apoptotic murine leukemia L1210 cells

Cytometry ◽  
2003 ◽  
Vol 56A (2) ◽  
pp. 89-95 ◽  
Author(s):  
R. O. Bilyy ◽  
R. S. Stoika
Keyword(s):  
L1210 Cells ◽  
Murine Leukemia
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