Recurrent renal cell carcinoma following nephrectomy mimicking a normal kidney on bone scan

1983 ◽  
Vol 8 (4) ◽  
Author(s):  
AhsenT. Ozarda ◽  
ThomasP. Haynie ◽  
CarlosR. Gutierrez
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Bone Scan ◽  
Normal Kidney ◽  
Recurrent Renal Cell Carcinoma

Detection of Recurrent Renal Cell Carcinoma by Three-Phase Bone Scan

1993 ◽  
Vol 18 (5) ◽  
pp. 441-443 ◽  
Author(s):  
DENNIS W. WULFECK ◽  
NOLAN K. SAKOW ◽  
SEYTHAN SENLER
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Bone Scan ◽  
Three Phase ◽  
Recurrent Renal Cell Carcinoma

scholarly journals The DEAD/DEAH Box Helicase, DDX11, Is Essential for the Survival of Advanced Clear Cell Renal Cell Carcinoma and Is a Determinant of PARP Inhibitor Sensitivity

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2574
Author(s):  
Jee Soo Park ◽  
Myung Eun Lee ◽  
Won Sik Jang ◽  
Koon Ho Rha ◽  
Seung Hwan Lee ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Quantitative Polymerase Chain Reaction ◽  
Parp Inhibitor ◽  
Renal Tumors ◽  
Low Grade ◽  
Normal Kidney ◽  
The Dead ◽  
The Impact

Genes associated with the DEAD-box helicase DDX11 are significant biomarkers of aggressive renal cell carcinoma (RCC), but their molecular function is poorly understood. We analyzed the molecular pathways through which DDX11 is involved in RCC cell survival and poly (ADP-ribose) polymerase (PARP) inhibitor sensitivity. Immunohistochemistry and immunoblotting determined DDX11 expression in normal kidney tissues, benign renal tumors, and RCC tissues and cell lines. Quantitative polymerase chain reaction validated the downregulation of DDX11 in response to transfection with DDX11-specific small interfering RNA. Proliferation analysis and apoptosis assays were performed to determine the impact of DDX11 knockdown on RCC cells, and the relevant effects of sunitinib, olaparib, and sunitinib plus olaparib were evaluated. DDX11 was upregulated in high-grade, advanced RCC compared to low-grade, localized RCC, and DDX11 was not expressed in normal kidney tissues or benign renal tumors. DDX11 knockdown resulted in the inhibition of RCC cell proliferation, segregation defects, and rapid apoptosis. DDX11-deficient RCC cells exhibited significantly increased sensitivity to olaparib compared to sunitinib alone or sunitinib plus olaparib combination treatments. Moreover, DDX11 could determine PARP inhibitor sensitivity in RCC. DDX11 could serve as a novel therapeutic biomarker for RCC patients who are refractory to conventional targeted therapies and immunotherapies.

scholarly journals IgG is involved in the migration and invasion of clear cell renal cell carcinoma

2015 ◽  
Vol 69 (6) ◽  
pp. 497-504 ◽  
Author(s):  
Zhengzuo Sheng ◽  
Yang Liu ◽  
Caipeng Qin ◽  
Zhenhua Liu ◽  
Yeqing Yuan ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Western Blot ◽  
Cell Carcinoma ◽  
Cell Lines ◽  
Renal Cell ◽  
Clear Cell ◽  
Migration And Invasion ◽  
Cancer Therapies ◽  
Normal Kidney ◽  
Cell Renal Cell Carcinoma

OBJECTIVE:To investigate if IgG can be expressed in clear cell renal cell carcinoma (cRCC) , and the expression of IgG is involved in the cancer progression. If IgG expression can serve as a potential target in cancer therapies and be used for judging the prognosis.MATERIALS AND METHODS:By immunohistochemistry, we detected IgG in cRCC tissues(75 cRCC tissues and75 adjacent normal kidney tissues). Immunofluorescence and Western blot was used to detect the IgG in cRCC cell lines (786-0, ACHN and CAKI-I). By RT-PCR, the functional transcript of IgG heavy chain was detected. Knockdown of IgG was to analyze the proliferation, migration and invasion ability by CCK8, Transwell and Matrigel and apoptosis in cRCC cell lines.RESULTS:By immunohistochemistry, we found strong staining of IgG in 66 cases of 75 cRCC tissues and 63 cases of 75 adjacent normal kidney tissues. Immunofluorescence and Western blot was found IgG in cRCC cell lines. Knock-down IgG in cRCC cell lines resulted in significant inhibition of cell proliferation, migration and invasion, and the induction of apoptosis of the 786-0 cells. The immunohistochemistry analysis showed that high IgG expression significantly correlated with the poor differentiation and advanced stage of cRCC.CONCLUSION:IgG was over expressed in cRCC and was involved in the proliferation, migration and invasion of cancer cells. IgG expression may serve as a potential target in cancer therapies and could be used for judging the prognosis.

Recurrent renal cell carcinoma: clinical and prognostic value of FDG PET/CT

2015 ◽  
Vol 43 (3) ◽  
pp. 464-473 ◽  
Author(s):  
Pierpaolo Alongi ◽  
Maria Picchio ◽  
Fabio Zattoni ◽  
Marianna Spallino ◽  
Luigi Gianolli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Fdg Pet ◽  
Renal Cell ◽  
Prognostic Value ◽  
Pet Ct ◽  
Recurrent Renal Cell Carcinoma ◽  
Fdg Pet Ct

scholarly journals Recurrent renal cell carcinoma leading to a misdiagnosis of polycystic liver disease: A case report

2019 ◽  
Vol 25 (18) ◽  
pp. 2264-2270 ◽  
Author(s):  
Chen Liang ◽  
Kazuhiro Takahashi ◽  
Masanao Kurata ◽  
Shingo Sakashita ◽  
Tatsuya Oda ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Case Report ◽  
Liver Disease ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Polycystic Liver Disease ◽  
Polycystic Liver ◽  
Recurrent Renal Cell Carcinoma

scholarly journals Recurrent Renal Cell Carcinoma with Synchronous Tumor Growth in Azygoesophageal Recess and Duodenum: A Rare Cause of Anemia and Upper Gastrointestinal Bleeding

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Vamshidhar R. Vootla ◽  
Muhammad Kashif ◽  
Masooma Niazi ◽  
Suresh K. Nayudu
Keyword(s):  
Renal Cell Carcinoma ◽  
Gastrointestinal Bleeding ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Upper Gastrointestinal Bleeding ◽  
Synchronous Tumor ◽  
Acute Upper Gastrointestinal Bleeding ◽  
Recurrent Renal Cell Carcinoma ◽  
Sites Of Metastases ◽  
Upper Gastrointestinal

Renal cell carcinoma (RCC) has potential to present with distant metastasis several years after complete resection. The common sites of metastases include the lungs, bones, liver, renal fossa, and brain. RCCs metastasize rarely to the duodenum, and duodenal metastasis presenting with acute gastrointestinal bleed is infrequently reported in literature. We present a case of synchronous presentation of duodenal and azygoesophageal metastasis manifesting as acute upper gastrointestinal bleeding, four years after undergoing nephrectomy for RCC. The patient underwent further workup and was treated with radiation. The synchronous presentation is rare and stresses the importance of searching for recurrence of RCC in patients presenting with acute gastrointestinal bleeding.

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