scholarly journals Rat bladder in the early stages of streptozotocin-induced diabetes: adrenergic and cholinergic innervation

Diabetologia ◽  
1984 ◽  
Vol 26 (1) ◽  
Author(s):  
J. Lincoin ◽  
M. Crockett ◽  
A.J. Haven ◽  
G. Burnstock
Keyword(s):  
Cholinergic Innervation ◽  
Early Stages ◽  
Rat Bladder ◽  
Streptozotocin Induced Diabetes ◽  
Adrenergic And Cholinergic Innervation

The Smooth Muscle of Rat Bladder in the Early Stages of Streptozotocin-induced Diabetes

1984 ◽  
Vol 56 (1) ◽  
pp. 24-30 ◽  
Author(s):  
J. LINCOLN ◽  
A. J. HAVEN ◽  
M. SAWYER ◽  
G. BURNSTOCK
Keyword(s):  
Smooth Muscle ◽  
Early Stages ◽  
Rat Bladder ◽  
Streptozotocin Induced Diabetes

scholarly journals Glycine receptor is differentially expressed in the rat retina at early stages of streptozotocin-induced diabetes

2019 ◽  
Vol 712 ◽  
pp. 134506 ◽  
Author(s):  
Elizabeth Morales-Calixto ◽  
Miguel Ángel Velázquez-Flores ◽  
Gustavo Sánchez-Chávez ◽  
Ruth Ruiz Esparza-Garrido ◽  
Rocío Salceda
Keyword(s):  
Glycine Receptor ◽  
Differentially Expressed ◽  
Rat Retina ◽  
Early Stages ◽  
Streptozotocin Induced Diabetes

scholarly journals Morphology and Contractility of Cardiac Myocytes in Early Stages of Streptozotocin-Induced Diabetes Mellitus in Rats

2013 ◽  
pp. 489-501 ◽  
Author(s):  
M. CAGALINEC ◽  
I. WACZULÍKOVÁ ◽  
O. ULIČNÁ ◽  
D. CHORVAT
Keyword(s):  
Ventricular Myocytes ◽  
Calcium Transient ◽  
Detection Algorithm ◽  
Heart Tissue ◽  
Left Ventricular ◽  
Contour Detection ◽  
Point Of View ◽  
Calcium Handling ◽  
Early Stages ◽  
Streptozotocin Induced Diabetes

Diabetic cardiomyopathy is the leading cause of mortality in type 1 diabetes. Thus study of cardiomyocyte morphology and function during early stages of diabetes using modern analytical methods is of critical importance. Therefore, using confocal microscopy, we determined metric parameters, volumes and contractility, with calcium transients in isolated left-ventricular myocytes at one week after induction of diabetes in rats. Myocyte volume analysis from 3D confocal scans was performed using an automated contour detection algorithm that took the actual shape of the myocytes into account. We showed a significant reduction in myocyte volume in diabetic animals. We also showed a significant reduction in length and width but not in thickness of the myocytes, which suggests disproportional reorganization of the structure of the heart tissue during short-term diabetes. From a functional point of view, we observed a significant decrease in cell shortening at a stimulation frequency of 0.5 Hz. This was accompanied by a decrease in calcium transient amplitude. Together, these data suggest that impaired calcium handling is one of the factors that contributes to the observed decrease in myocyte shortening during early stages of streptozotocin-induced diabetes in rats.

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