scholarly journals Encephalomyocarditis virus induced diabetes mellitus in mice: Long-term changes in the structure and function of islets of langerhans

Diabetologia ◽  
1983 ◽  
Vol 25 (1) ◽  
Author(s):  
K. Iwo ◽  
S.C. Bellomo ◽  
N. Mukai ◽  
J.E. Craighead
Keyword(s):  
Diabetes Mellitus ◽  
Islets Of Langerhans ◽  
Structure And Function ◽  
Encephalomyocarditis Virus ◽  
Long Term Changes ◽  
And Function

Long-term changes in structure and function of a tropical headwater stream following a disease-driven amphibian decline

2014 ◽  
Vol 60 (3) ◽  
pp. 575-589 ◽  
Author(s):  
Heidi M. Rantala ◽  
Amanda M. Nelson ◽  
Jessica N. Fulgoni ◽  
Matt R. Whiles ◽  
Robert O. Hall ◽  
...  
Keyword(s):  
Amphibian Decline ◽  
Structure And Function ◽  
Headwater Stream ◽  
Long Term Changes ◽  
And Function

scholarly journals Maternal Creatine Supplementation during Pregnancy Prevents Long-Term Changes in Diaphragm Muscle Structure and Function after Birth Asphyxia

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0149840 ◽  
Author(s):  
Domenic A. LaRosa ◽  
Stacey J. Ellery ◽  
Helena C. Parkington ◽  
Rod J. Snow ◽  
David W. Walker ◽  
...  
Keyword(s):  
Creatine Supplementation ◽  
Birth Asphyxia ◽  
Structure And Function ◽  
Diaphragm Muscle ◽  
Muscle Structure ◽  
Long Term Changes ◽  
And Function

Lung Structure And Function Relation In Elastase-Treated Rats: A Long-Term Follow Up Study

2012 ◽  
Author(s):  
Margit V. Szabari ◽  
Jozsef Tolnai ◽  
Balazs Maar ◽  
Harikrishnan Parameswaran ◽  
Elizabeth Bartolak-Suki ◽  
...  
Keyword(s):  
Structure And Function ◽  
Follow Up Study ◽  
Lung Structure ◽  
Long Term Follow Up ◽  
And Function ◽  
Function Relation

Abstract P138: Long-term Effects Of Severe Caloric Restriction To The Heart Function

Hypertension ◽  
2021 ◽  
Vol 78 (Suppl_1) ◽  
Author(s):  
Aline M De Souza ◽  
Jonathas Almeida ◽  
Nataliia Shults ◽  
Hong Ji ◽  
Kathryn Sandberg
Keyword(s):  
Cardiovascular Disease ◽  
Caloric Restriction ◽  
Heart Function ◽  
Left Ventricular ◽  
Structure And Function ◽  
Long Term Effects ◽  
Isolated Hearts ◽  
Ad Libitum ◽  
And Function

Severe caloric restriction (sCR) increases the risk for acute cardiovascular disease. Less understood are the long-term effects on cardiovascular disease risk after the sCR period has ended. We investigated the effects of sCR on heart structure and function months after refeeding (sCR-Refed). Female Fischer rats (3-months-old) were maintained on (CT) ad libitum or a 60% caloric restricted diet for 2 weeks. Thereafter, all rats received ad libitum chow for 3 months and they were analyzed by precision ultrasound to assess their heart function. After imaging, the animals were sacrificed and the hearts were subjected to ischemia-reperfusion (I/R) using a Langendorff preparation. After 2 weeks of sCR, rats lost 15% of their initial body weight (BW) [% (100*(Final-Initial/Initial)): CT, 1.5±0.8 vs sCR, -15.4±1.1; p<0.001;n=8]. After 3 months of refeeding, there was no detectable difference in BW between CT and sFR-Refed groups. Isolated hearts from the sCR-Refed rats exhibited worse myocardial pathology after I/R compared to CT rats. The parallel orientation of myofibers and striations normally present in cardiomyocytes was lost in sCR-Refed rats. Further analysis revealed uneven blood-filling of the microcirculatory vessels and prominent interstitial edema of the myocardium. Hearts from sCR-Refed rats had more atrophied cardiomyocytes than CT [Atrophied/Total (%): CT, 0.2±0.1 vs sCR-Refed, 50.6±1.1; p<0.001; n=5]. The number of arrhythmic events during a 30 min ischemic interval in isolated hearts doubled after 2 weeks on the sCR diet ( data not shown ) and remained doubled 3 months later [Arrhythmias (% of time): CT, 34±8 vs sCR-Refed, 68±9; p=0.02; n=8]. Ultrasound imaging showed no difference in stroke volume, coronary perfusion pressure and left ventricular mass. However, the thickness of the left ventricular posterior wall was significantly reduced in sCR-Refed rats [(mm): CT, 2.55 ±0.03 vs sCR-Refed, 2.10±0.04; p=0.002; n=4]. These findings indicate heart structure and function remained damaged months after the sCR period ended and BW was restored. These studies have adverse cardiovascular risk implications for who are subjected either voluntarily (crash diets) or involuntarily (very low food security) to periods of inadequate caloric intake.

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