Mapping of the colocalization of calretinin and tyrosine hydroxylase in the rat substantia nigra and ventral tegmental area

1994 ◽  
Vol 99 (1) ◽  
Author(s):  
KrystynaR. Isaacs ◽  
DavidM. Jacobowitz
Keyword(s):  
Tyrosine Hydroxylase ◽  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Ventral Tegmental ◽  
Rat Substantia Nigra

NMDA alters rotenone toxicity in rat substantia nigra zona compacta and ventral tegmental area dopamine neurons

2012 ◽  
Vol 33 (3) ◽  
pp. 429-435 ◽  
Author(s):  
Adam C. Munhall ◽  
Yan-Na Wu ◽  
John K. Belknap ◽  
Charles K. Meshul ◽  
Steven W. Johnson
Keyword(s):  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Dopamine Neurons ◽  
Ventral Tegmental ◽  
Rat Substantia Nigra

scholarly journals Understanding the Mechanism of Antidepressant-Related Sexual Dysfunction: Inhibition of Tyrosine Hydroxylase in Dopaminergic Neurons after Treatment with Paroxetine but Not with Agomelatine in Male Rats

2019 ◽  
Vol 8 (2) ◽  
pp. 133 ◽  
Author(s):  
Yanira Santana ◽  
Angel Montejo ◽  
Javier Martín ◽  
Ginés LLorca ◽  
Gloria Bueno ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Tyrosine Hydroxylase ◽  
Sexual Dysfunction ◽  
Substantia Nigra ◽  
Ventral Tegmental Area ◽  
Median Eminence ◽  
Zona Incerta ◽  
Mediobasal Hypothalamus ◽  
Ventral Tegmental ◽  
Serotonergic Antidepressant

Antidepressant-related sexual dysfunction is a frequent adverse event caused by serotonergic activation that intensely affects quality of life and adherence in depressed patients. The dopamine system has multiple effects promoting sexual behavior, but no studies have been carried out to confirm dopaminergic changes involved in animal models after antidepressant use. Methods: The sexual behavior-related dopaminergic system in the rat was studied by comparing two different antidepressants and placebo for 28 days. The antidepressants used were paroxetine (a serotonergic antidepressant that causes highly frequent sexual dysfunction in humans) and agomelatine (a non-serotonergic antidepressant without associated sexual dysfunction). The tyrosine hydroxylase immunoreactivity (THI) in the substantia nigra pars compacta, the ventral tegmental area, the zona incerta, and the hypothalamic arcuate nucleus, as well as the dopaminergic projections to the striatum, hippocampus, cortex, and median eminence were analyzed. Results: The THI decreased significantly in the substantia nigra and ventral tegmental area after treatment with paroxetine, and the labeling was reduced drastically in the zona incerta and mediobasal hypothalamus. The immunoreactive axons in the target regions (striatum, cortex, hippocampus, and median eminence) almost disappeared only in the paroxetine-treated rats. Conversely, after treatment with agomelatine, a moderate reduction in immunoreactivity in the substantia nigra was found without appreciable modifications in the ventral tegmental area, zona incerta, and mediobasal hypothalamus. Nevertheless, no sexual or copulatory behavior was observed in any of the experimental or control groups. Conclusion: Paroxetine but not agomelatine was associated with important decreased activity in dopaminergic areas such as the substantia nigra and ventral tegmental areas that could be associated with sexual performance impairment in humans after antidepressant treatment.

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