Vascular response in a non-uterine site to implantation-stage embryos following interspecies transfers between the rat, mouse, and guinea-pig

1989 ◽  
Vol 258 (2) ◽  
Author(s):  
A.M. Macpherson ◽  
P.A.W. Rogers ◽  
L.A. Beaton
Keyword(s):  
Guinea Pig ◽  
Vascular Response

XVI.—Observations on Artificially Induced Heat in Immature Guinea-Pigs

1942 ◽  
Vol 61 (2) ◽  
pp. 188-196 ◽  
Author(s):  
P. Bacsich ◽  
G. M. Wyburn
Keyword(s):  
Guinea Pig ◽  
Hormonal Treatment ◽  
Complete Response ◽  
Hormonal Activity ◽  
Vascular Response ◽  
Histological Changes ◽  
Vascular Change ◽  
Immature Animal ◽  
Uterine Endometrium ◽  
Number Of Authors

Treatment of the immature animal with æstrogenic or gonadotropic substances has been described by a number of authors in diverse experiments, and vaginal cornification, enlargement and typical histological changes in the uterus, ovulation, mating, and fertilisation, have all been produced, but no successful implantation. The histological changes which occur in the uterus and vagina of the treated immature animal are considered (Reynolds and others) to be characteristic of heat and similar to those in the adult uterus during heat. Nevertheless, it is suggested that the failure to procure implantation in treated immature animals may be due to an unfavourable condition of the uterine endometrium. If that is so, there must exist some difference between the response of the treated immature uterus and that of the mature uterus during cestrus which has thus far escaped detection. Recently we have described (Bacsich and Wyburn, 1940b) a cyclic vascular change in the uterus of the guinea-pig in the form of antimesometric hyperæmia present only during normal heat, and, moreover, have been able to induce this vascular response in spayed animals by hormonal treatment (Bacsich and Wyburn, 1941). As this cyclic vascular change provides a particularly delicate test of a complete response of the uterus to ovarian hormonal activity and may influence the site and the course of implantation, it seemed of interest to ascertain if the “characteristic” œstrogenic response of the immature uterus included antimesometric hyperæmia.

Different hepatic vascular response to noradrenaline and histamine between guinea-pig and rat

2004 ◽  
Vol 180 (3) ◽  
pp. 255-263 ◽  
Author(s):  
T. Shibamoto ◽  
M. Narushima ◽  
Y.-Q. Ling ◽  
T. Shimo ◽  
H. Tsuchida ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Vascular Response

Histaminergic receptors modulate the coronary vascular response in isolated guinea pig hearts. Role of nitric oxide

2003 ◽  
Vol 52 (9) ◽  
pp. 390-396 ◽  
Author(s):  
S. Pierpaoli ◽  
C. Marzocca ◽  
M. G. Bello ◽  
W. Schunack ◽  
P. F. Mannaioni ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Guinea Pig ◽  
Vascular Response

Effect of Contraceptive Steroids on the Endometrium of Guinea Pig: SEM study

1977 ◽  
Vol 35 ◽  
pp. 668-669
Author(s):  
Mai M. Said ◽  
Ramesh K. Nayak ◽  
Randall E. McCoy
Keyword(s):  
Guinea Pig ◽  
Reproductive Tract ◽  
Three Dimensional ◽  
Female Reproductive Tract ◽  
Human Female ◽  
Surface Ultrastructure ◽  
Transmission Electron ◽  
Sem Study ◽  
Uterine Mucosa ◽  
Group 1

Burgos and Wislocki described changes in the mucosa of the guinea pig uterus, cervix and vagina during the estrous cycle investigated by transmission electron microscopy. More recently, Moghissi and Reame reported the effects of progestational agents on the human female reproductive tract. They found drooping and shortening of cilia in norgestrel and norethindrone- treated endometria. To the best of our knowledge, no studies concerning the effects of mestranol and norethindrone given concurrently on the three-dimensional surface features on the uterine mucosa of the guinea pig have been reported. The purpose of this study was to determine the effect of mestranol and norethindrone on surface ultrastructure of guinea pig uterus by SEM.Seventy eight animals were used in this study. They were allocated into two groups. Group 1 (20 animals) was injected intramuscularly 0.1 ml vegetable oil and served as controls.

Ultrastructure and Drug Metabolism in the Developing Guinea Pig

1973 ◽  
Vol 31 ◽  
pp. 538-539
Author(s):  
W. Kuenzig ◽  
M. Boublik ◽  
J.J. Kamm ◽  
J.J. Burns
Keyword(s):  
Guinea Pig ◽  
Metabolic Activity ◽  
Animal Species ◽  
Adult Animal ◽  
Smooth Endoplasmic Reticulum ◽  
Fetal Life ◽  
Mixed Function Oxidase ◽  
Cytochrome P 450 ◽  
Microsomal Mixed Function Oxidase ◽  
Mixed Function Oxidase Activity

Unlike a variety of other animal species, such as the rabbit, mouse or rat, the guinea pig has a relatively long gestation period and is a more fully developed animal at birth. Kuenzig et al. reported that drug metabolic activity which increases very slowly during fetal life, increases rapidly after birth. Hepatocytes of a 3-day old neonate metabolize drugs and reduce cytochrome P-450 at a rate comparable to that observed in the adult animal. Moreover the administration of drugs like phenobarbital to pregnant guinea pigs increases the microsomal mixed function oxidase activity already in the fetus.Drug metabolic activity is, generally, localized within the smooth endoplasmic reticulum (SER) of the hepatocyte.

Glycogen in guinea pig neutrophils: Ultrastructural study of neutrophils at the intradermal site of BCG injection

1983 ◽  
Vol 41 ◽  
pp. 726-727
Author(s):  
Corazon D. Bucana
Keyword(s):  
Bone Marrow ◽  
Guinea Pig ◽  
Electron Density ◽  
Peritoneal Cavity ◽  
Ultrastructural Study ◽  
Guinea Pigs ◽  
Random Distribution ◽  
Glycogen Content ◽  
Polymorphonuclear Neutrophils ◽  
Ultrastructural Studies

In the circulating blood of man and guinea pigs, glycogen occurs primarily in polymorphonuclear neutrophils and platelets. The amount of glycogen in neutrophils increases with time after the cells leave the bone marrow, and the distribution of glycogen in neutrophils changes from an apparently random distribution to large clumps when these cells move out of the circulation to the site of inflammation in the peritoneal cavity. The objective of this study was to further investigate changes in glycogen content and distribution in neutrophils. I chose an intradermal site because it allows study of neutrophils at various stages of extravasation.Initially, osmium ferrocyanide and osmium ferricyanide were used to fix glycogen in the neutrophils for ultrastructural studies. My findings confirmed previous reports that showed that glycogen is well preserved by both these fixatives and that osmium ferricyanide protects glycogen from solubilization by uranyl acetate.I found that osmium ferrocyanide similarly protected glycogen. My studies showed, however, that the electron density of mitochondria and other cytoplasmic organelles was lower in samples fixed with osmium ferrocyanide than in samples fixed with osmium ferricyanide.

Ultrastructural Studies on Genital Infection with the Chlamydial Agent of Guinea Pig Inclusion Conjunctivitis

1977 ◽  
Vol 35 ◽  
pp. 352-353
Author(s):  
B. L. Soloff ◽  
A. L. Barron ◽  
H. J. White ◽  
R. G. Rank
Keyword(s):  
Guinea Pig ◽  
Sexual Contact ◽  
Chlamydia Psittaci ◽  
Genital Infection ◽  
Major Site ◽  
Ultrastructural Studies ◽  
Tissue Specimens ◽  
Guinea Pig Model ◽  
Adequate Tissue ◽  
Genital Tissue

Chlamydial organisms (specifically C. trachomatis) have been implicated as a frequent cause of genital infection in the human (1). Study of the histo- pathological aspects of such infections has been impeded because of difficulties in obtaining adequate tissue specimens and the lack of a suitable experimental host. In 1964, Murray (2) isolated the causative agent of guinea pig inclusion conjunctivitis which possesses similarities to human inclusion conjunctivitis. This guinea pig organism was found to be a member of the Chlamydia psittaci subgroup and was designated as the Gp-ic agent. Male guinea pigs have been successfully infected with Gp-ic by intraurethral inoculation. Transmission of the infection to the female by sexual contact has been demonstrated (3). We are not aware of any ultrastructural studies to date concerning the development of this agent in genital tissue.Studies in our laboratory have established that, in our guinea pig model, the cervix is the major site of injection.

Ultrastructural and chemical evidences of heterogeneity and hormone dependence of certain glycocalyces

1978 ◽  
Vol 36 (2) ◽  
pp. 322-323
Author(s):  
B. Monis ◽  
D. Lis ◽  
I. Parlanti ◽  
A. R. Eynard ◽  
M. A. Valentich ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Concanavalin A ◽  
Ruthenium Red ◽  
Transitional Epithelium ◽  
Membrane Material ◽  
Hormone Dependence ◽  
Cellulose Acetate Electrophoresis ◽  
Electrophoretic Data ◽  
Fat Globule ◽  
Collecting Tubules

We are gathering evidences which indicate ultrastructural variations and chemical heterogeneity of certain glycocalyces as well as hormone dependence of some of them. Thus, in the lumenal glycocalyx of renal collecting tubules of the guinea-pig granular and filamentous structures were seen (1, fig. 1). By isolation, chemical analysis and cellulose acetate electrophoresis in various buffers of tubular membrane material, glycopeptides and glycosaminoglycans were identified (fig. 2).Guinea-pig and rat transitional epithelium of urinary tract showed a filamentous lumenal glycocalyx demonstrable with ruthenium red (fig. 3) but which only in part stained with concanavalin A. Chemical and electrophoretic data indicated that urothelium contains glycoproteins, glycosaminoglycans and glycolipids.The glycocalyx of the fat globule membrane of milk of several species has a granular appearance as shown by cationic dyes and by concanavalin A (2, 3, fig. 4 and 5). Also, several glycoproteins were isolated and identified on polyacrilamide gel electrophoresis (fig. 6). Glycosaminoglycans and certain glycolipids such as sulfatides were chemically identified in this glycocalyx.

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