The role of technetium-99m sestamibi whole-body scans in diagnosing metastatic Hurthle cell carcinoma of the thyroid gland after total thyroidectomy: a comparison with iodine-131 and thallium-201 whole-body scans

1994 ◽  
Vol 21 (9) ◽  
Author(s):  
Tzu-Chen Yen ◽  
Hong-Dar Line ◽  
Chen-Hsen Lee ◽  
Shu-Liam Change ◽  
Shin-Hwa Yeh
Keyword(s):  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Total Thyroidectomy ◽  
Thallium 201 ◽  
Whole Body ◽  
Technetium 99M Sestamibi ◽  
Technetium 99M ◽  
Hurthle Cell Carcinoma ◽  
Iodine 131

scholarly journals Cervical thymoma

1999 ◽  
Vol 117 (3) ◽  
pp. 132-135 ◽  
Author(s):  
Abrão Rapoport ◽  
Claudiane Ferreira Dias ◽  
João Paulo Aché de Freitas ◽  
Ricardo Pires de Souza
Keyword(s):  
Case Report ◽  
Thyroid Gland ◽  
Rare Disease ◽  
Female Patient ◽  
Thallium 201 ◽  
Accurate Diagnosis ◽  
Nuclear Resonance ◽  
Histological Findings ◽  
History Of ◽  
Iodine 131

CONTEXT: Cervical thymoma is a primitive thymic neoplasia. It is very rare. This disease presents higher incidence in female patients in their 4th to 6th decade of life. We present a case report of a cervical thymoma CASE REPORT: 54-year-old female patient, caucasian, with no history of morbidity, presenting a left cervical nodule close to the thyroid gland. During the 30 months of investigation a left cervical nodule grew progressively next to the thyroid while the patient showed no symptoms, making accurate diagnosis difficult. Tests on her thyroid function did not show changes, nor were there changes in any subsidiary tests. The diagnosis of the disease was made intra-operatively through total thyroid individualization. The results were confirmed by the histological findings from the ressected material. Cervical thymoma is a very rare disease, with difficult preoperatory diagnosis. Some additional study methods which are employed today are thallium 201, technetium 99 and iodine 131 scintigraphy, magnetic nuclear resonance and especially histopathological findings and classification.

scholarly journals Is there a role of whole-body bone scan in patients with esophageal squamous cell carcinoma

BMC Cancer ◽  
2012 ◽  
Vol 12 (1) ◽  
Author(s):  
Shau-Hsuan Li ◽  
Yung-Cheng Huang ◽  
Wan-Ting Huang ◽  
Wei-Che Lin ◽  
Chien-Ting Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Bone Scan ◽  
Whole Body ◽  
Body Bone

Preoperative Parathyroid Localization: Prospective Evaluation of Technetium 99m Sestamibi

1994 ◽  
Vol 111 (4) ◽  
pp. 467-472 ◽  
Author(s):  
Anjum Khan ◽  
Sameer Samtani ◽  
Vijay M. Varma ◽  
Andra Frost ◽  
Joshua Cohen
Keyword(s):  
Surgical Procedures ◽  
Surgical Approach ◽  
Thallium 201 ◽  
Parathyroid Glands ◽  
Technetium 99M Sestamibi ◽  
George Washington ◽  
Technetium 99M ◽  
Experienced Surgeon ◽  
Parathyroid Localization ◽  
Washington University

The utility of preoperative parathyroid localization remains controversial. The gold standard for Identification of abnormal parathyroid glands is exploration of the neck by an experienced surgeon. However, both for the experienced and less experienced surgeon. It may be desirable to localize the abnormality before surgery. Such a study would not only direct the surgeon to the site of the lesion but also would help reduce unnecessary dissection, the number of negative explorations, and operative anesthesia time. Unfortunately, currently used noninvasive techniques including ultrasonography, thalllum-technetium subtraction, computed tomography scan, and magnetic resonance Imaging have had only limited success (35% to 78%) In demonstrating abnormal parathyroid glands. Thirty patients with proven hyperparathyroidism were enrolled to compare a new imaging agent, technetium 99m sestamibi, as an alternative to thallium 201 for subtraction scintigraphy with technetium 99m pertechnetate. Only 14 of 30 patients operated on at George Washington University underwent an identical surgical approach (exploration of all four glands) and had complete preoperative calcium and parathormone levels, postoperative calcium levels, and total time of surgical procedures to formulate the basis of this report. The remaining 16 had their surgeries at other Institutions. A surgical approach different from that used at George Washington University and unavailability of postoperative calcium levels and times of surgical procedures from these Institutions necessitated deletion of these 16 patients from this report. Technetium 99m sestamibl—technetium 99m subtraction scans accurately localized the abnormal parathyroid gland in 13 of 14 patients, as compared with only 9 of 14 thallium 201–technetium 99m pertechnetate subtraction scans. These results support technetium 99m sestamibl scanning as the superior modality for preoperative parathyroid localization.

Histological Patterns of Locoregional Recurrence in Hürthle Cell Carcinoma of the Thyroid Gland

Thyroid ◽  
2012 ◽  
pp. 120301085144008
Author(s):  
Justin Bishop ◽  
Gaosong Wu ◽  
Ralph P. Tufano ◽  
William H Westra
Keyword(s):  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Locoregional Recurrence ◽  
Hürthle Cell ◽  
Hürthle Cell Carcinoma ◽  
Hurthle Cell Carcinoma

Attenuation-corrected rest thallium-201/stress technetium 99m sestamibi myocardial SPECT in normals*

1998 ◽  
Vol 5 (1) ◽  
pp. 48-55 ◽  
Author(s):  
I MATSUNARI ◽  
G BONING ◽  
S ZIEGLER ◽  
I KOSA ◽  
S NEKOLLA ◽  
...  
Keyword(s):  
Thallium 201 ◽  
Myocardial Spect ◽  
Technetium 99M Sestamibi ◽  
Technetium 99M ◽  
Attenuation Corrected

scholarly journals Metastases of Renal Cell Carcinoma to the Thyroid Gland with Synchronous Benign and Malignant Follicular Cell-Derived Neoplasms

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Carlos Zamarrón ◽  
Ihab Abdulkader ◽  
María C. Areses ◽  
Vanesa García-Paz ◽  
Luís León ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Growth Factor ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Growth Factor Receptor ◽  
Follicular Adenoma ◽  
Distant Metastases ◽  
Whole Body ◽  
Cell Renal Cell Carcinoma

Clear cell renal cell carcinoma (CCRCC) is the most common origin for metastasis in the thyroid. A 51-year-old woman was referred to our hospital for a subcarinal lesion. Ten years before, the patient had undergone a nephrectomy for CCRCC. Whole-body fluorodeoxyglucose positron emission tomography revealed elevated values in the thyroid gland, while the mediastinum was normal. An endoscopic ultrasonography-guided fine-needle aspiration biopsy of the mediastinal mass was consistent with CCRCC, and this was confirmed after resection. The thyroidectomy specimen also revealed lymphocytic thyroiditis, nodular hyperplasia, one follicular adenoma, two papillary microcarcinomas, and six foci of metastatic CCRCC involving both thyroid lobes. Curiously two of the six metastatic foci were located inside two adenomatoid nodules (tumor-in-tumor). The metastatic cells were positive for cytokeratins, CD10, epidermal growth factor receptor, and vascular endothelial growth factor receptor 2. NoBRAFgene mutations were found in any of the primary and metastatic lesions. The patient was treated with sunitinib and finally died due to CCRCC distant metastases 6 years after the thyroidectomy. In CCRCC patients, a particularly prolonged survival rate may be achieved with the appropriate therapy, in contrast to the ominous prognosis typically found in patients with thyroid metastases from other origins.

scholarly journals Appearance of Hürthle cell carcinoma soon after surgical extirpation of Hürthle cell adenoma and follicular adenoma of the thyroid gland

2015 ◽  
Vol 49 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Nevena Ristevska ◽  
Sinisa Stojanoski ◽  
Daniela Pop Gjorceva
Keyword(s):  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Tumour Size ◽  
Follicular Adenoma ◽  
Needle Aspiration ◽  
Cell Adenoma ◽  
Rare Tumour ◽  
Hürthle Cell ◽  
Hürthle Cell Carcinoma ◽  
Hurthle Cell Carcinoma

Abstract Background. Hürthle cell neoplasms could be benign (Hürthle cell adenoma) or malignant (Hürthle cell carcinoma). Hürthle cell carcinoma is a rare tumour, representing 5% of all differentiated thyroid carcinomas. The cytological evaluation of Hürthle cell neoplasms by fine needle aspiration biopsy (FNAB) is complicated because of the presence of Hürthle cells in both Hürthle cell adenoma and Hürthle cell carcinoma. Thus, the preoperative distinction between these two entities is very difficult and possible only with pathohistological findings of the removed tumour. Case report. A 57-year old female patient was admitted at our Department, for investigation of nodular thyroid gland. She was euthyroid and FNAB of the nodules in both thyroid lobes were consistent of Hürthle cell adenoma with cellular atypias. After thyroidectomy the histopathology revealed Hürthle cell adenoma with high cellular content and discrete cellular atypias in the left lobe and follicular thyroid adenoma without cellular atypias in the right lobe. One year after substitution therapy, a palpable tumour on the left side of the remnant tissue was found, significantly growing with time, presented as hot nodule on 99mTc-sestamibi scan and conclusive with Hürthle cell adenoma with marked cellularity on FNAB. Tumorectomy was performed and well-differentiated Hürthle cell carcinoma detected. The patient received ablative dose of 100 mCi 131I. No signs of metastatic disease are present up to date. Conclusions. The differences between Hürthle cell adenomas and Hürthle cell carcinomas could be clearly made only by histopathological evaluation. Patients with cytological diagnosis of Hürthle cell neoplasms should proceed to total thyroidectomy, especially if tumour size is > 1cm, FNAB findings comprise cellular atypias and/or multiple bilateral nodules are detected in the thyroid gland.

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