scholarly journals Effects of neonatal monocular enucleation on the number of GAD-positive puncta in rat visual cortex

1986 ◽  
Vol 62 (1) ◽  
Author(s):  
C.E. Ribak ◽  
R.T. Robertson
Keyword(s):  
Visual Cortex ◽  
Monocular Enucleation

The cross-modal aspect of mouse visual cortex plasticity induced by monocular enucleation is age dependent

2014 ◽  
Vol 522 (4) ◽  
pp. 950-970 ◽  
Author(s):  
Julie Nys ◽  
Jeroen Aerts ◽  
Ellen Ytebrouck ◽  
Samme Vreysen ◽  
Annelies Laeremans ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Monocular Enucleation ◽  
Age Dependent ◽  
The Cross ◽  
Mouse Visual Cortex

scholarly journals Blockade of retinal or cortical activity does not prevent the development of callosal patches normally associated with ocular dominance columns in primary visual cortex

2021 ◽  
Vol 38 ◽  
Author(s):  
Hsueh Chung Lu ◽  
Robyn J. Laing ◽  
Jaime F. Olavarria
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Neural Activity ◽  
Single Injection ◽  
Ocular Dominance ◽  
Cell Activity ◽  
Ocular Dominance Columns ◽  
Callosal Connections ◽  
Monocular Enucleation ◽  
Physiological Evaluation

Abstract Callosal patches in primary visual cortex of Long Evans rats, normally associated with ocular dominance columns, emerge by postnatal day 10 (P10), but they do not form in rats monocularly enucleated a few days before P10. We investigated whether we could replicate the results of monocular enucleation by using tetrodotoxin (TTX) to block neural activity in one eye, or in primary visual cortex. Animals received daily intravitreal (P6–P9) or intracortical (P7–P9) injections of TTX, and our physiological evaluation of the efficacy of these injections indicated that the blockade induced by a single injection lasted at least 24 h. Four weeks later, the patterns of callosal connections in one hemisphere were revealed after multiple injections of horseradish peroxidase in the other hemisphere. We found that in rats receiving either intravitreal or cortical injections of TTX, the patterns of callosal patches analyzed in tangential sections from the flattened cortex were not significantly different from the pattern in normal rats. Our findings, therefore, suggest that the effects of monocular enucleation on the distribution of callosal connections are not due to the resulting imbalance of afferent ganglion cell activity, and that factors other than neural activity are likely involved.

Monocular enucleation prevents retinal ganglion-cell loss following neonatal visual cortex damage in cats

1998 ◽  
Vol 15 (6) ◽  
pp. 1097-1105 ◽  
Author(s):  
KURT R. ILLIG ◽  
VON R. KING ◽  
PETER D. SPEAR
Keyword(s):  
Visual Cortex ◽  
Ganglion Cell ◽  
Ganglion Cells ◽  
Cell Loss ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Medium Size ◽  
Retinal Ganglion ◽  
Retrograde Degeneration ◽  
Monocular Enucleation ◽  
Binocular Interactions

Damage to primary visual cortex (VC) in young cats leads to severe retrograde degeneration of the dorsal lateral geniculate nucleus (dLGN) and selective transneuronal retrograde degeneration of a class of retinal ganglion cells (RGCs) that have a medium-size soma. Previous studies have shown that “programmed” RGC death associated with normal development in one eye can be attenuated by removal of the other eye, suggesting that binocular interactions can influence developmental RGC death. The present study investigated whether removal of one eye also attenuates the ganglion cell loss that accompanies an early VC lesion. Five one-week-old cats received a unilateral VC lesion (areas 17, 18, and 19), and three of these cats also underwent monocular enucleation at the same time. Two normal control animals also were examined. RGC measurements were made from flat-mounted retinae when the animals were 5 weeks old. Sampling was restricted to a retinal area corresponding to the retinotopic representation included in the VC lesion. Results indicate that there is a marked loss of medium-size RGCs in the hemiretinae projecting to the damaged hemisphere in cats that received a VC lesion alone. However, there is no such loss in VC-lesion animals that also have a monocular enucleation. These results indicate that the transneuronal RGC loss that occurs after an early visual cortex lesion can be influenced by binocular interactions.

1729 Effects of monocular enucleation on parvalbumin immunoreactivity in the rat visual cortex

1996 ◽  
Vol 25 ◽  
pp. S200
Author(s):  
Yoritsugu Hada ◽  
Yuko Yamada ◽  
Misao Yamamoto ◽  
Kazuyuki Imamura ◽  
Tsuyoshi Shiomitsu ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Monocular Enucleation

scholarly journals Evidence for Cross-Modal Plasticity in Adult Mouse Visual Cortex Following Monocular Enucleation

2011 ◽  
Vol 21 (9) ◽  
pp. 2133-2146 ◽  
Author(s):  
L. Van Brussel ◽  
A. Gerits ◽  
L. Arckens
Keyword(s):  
Visual Cortex ◽  
Adult Mouse ◽  
Monocular Enucleation ◽  
Mouse Visual Cortex

Modified distribution patterns of responses in rat visual cortex induced by monocular enucleation

Neuroscience ◽  
1988 ◽  
Vol 24 (1) ◽  
pp. 59-66 ◽  
Author(s):  
J. Toldi ◽  
F. Joo ◽  
O. Feher ◽  
J.R. Wolff
Keyword(s):  
Visual Cortex ◽  
Distribution Patterns ◽  
Monocular Enucleation
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