Correlations among climbing fiber responses of nearby cerebellar Purkinje cells in the immature rat

1979 ◽  
Vol 37 (3) ◽  
Author(s):  
J.L. Dupont ◽  
F. Crepel
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Immature Rat ◽  
Cerebellar Purkinje Cells ◽  
Climbing Fiber Responses

scholarly journals Responses of cerebellar Purkinje cells during fictive optomotor behavior in larval zebrafish

2016 ◽  
Vol 116 (5) ◽  
pp. 2067-2080 ◽  
Author(s):  
Karina Scalise ◽  
Takashi Shimizu ◽  
Masahiko Hibi ◽  
Nathaniel B. Sawtell
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Visual Responses ◽  
Optomotor Response ◽  
General Role ◽  
Larval Stages ◽  
Larval Zebrafish ◽  
Electrophysiological Recordings ◽  
Cerebellar Purkinje Cells ◽  
Climbing Fiber Responses

Although most studies of the cerebellum have been conducted in mammals, cerebellar circuitry is highly conserved across vertebrates, suggesting that studies of simpler systems may be useful for understanding cerebellar function. The larval zebrafish is particularly promising in this regard because of its accessibility to optical monitoring and manipulations of neural activity. Although several studies suggest that the cerebellum plays a role in behavior at larval stages, little is known about the signals conveyed by particular classes of cerebellar neurons. Here we use electrophysiological recordings to characterize subthreshold, simple spike, and climbing fiber responses in larval zebrafish Purkinje cells in the context of the fictive optomotor response (OMR)—a paradigm in which fish adjust motor output to stabilize their virtual position relative to a visual stimulus. Although visual responses were prominent in Purkinje cells, they lacked the direction or velocity sensitivity that would be expected for controlling the OMR. On the other hand, Purkinje cells exhibited strong responses during fictive swim bouts. Temporal characteristics of these responses are suggestive of a general role for the larval zebrafish cerebellum in controlling swimming. Climbing fibers encoded both visual and motor signals but did not appear to encode signals that could be used to adjust OMR gain, such as retinal slip. Finally, the observation of diverse relationships between simple spikes and climbing fiber responses in individual Purkinje cells highlights the importance of distinguishing between these two types of activity in calcium imaging experiments.

Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules

2008 ◽  
Vol 68 (8) ◽  
pp. 997-1006 ◽  
Author(s):  
Mathieu Letellier ◽  
Melina L. Willson ◽  
Vanessa Gautheron ◽  
Jean Mariani ◽  
Ann M. Lohof
Keyword(s):  
Purkinje Cells ◽  
Mhc Class I ◽  
Climbing Fiber ◽  
Class I ◽  
Normal Adult ◽  
Cerebellar Purkinje Cells ◽  
Mhc Class I Molecules

scholarly journals Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells

2019 ◽  
Vol 22 (6) ◽  
pp. 950-962 ◽  
Author(s):  
Dimitar Kostadinov ◽  
Maxime Beau ◽  
Marta Blanco-Pozo ◽  
Michael Häusser
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Cerebellar Purkinje Cells

scholarly journals Voltage- and Branch-Specific Climbing Fiber Responses in Purkinje Cells

Cell Reports ◽  
2018 ◽  
Vol 24 (6) ◽  
pp. 1536-1549 ◽  
Author(s):  
Yunliang Zang ◽  
Stéphane Dieudonné ◽  
Erik De Schutter
Keyword(s):  
Purkinje Cells ◽  
Climbing Fiber ◽  
Climbing Fiber Responses

scholarly journals Impaired motor coordination and persistent multiple climbing fiber innervation of cerebellar Purkinje cells in mice lacking G q

1997 ◽  
Vol 94 (25) ◽  
pp. 14089-14094 ◽  
Author(s):  
S. Offermanns ◽  
K. Hashimoto ◽  
M. Watanabe ◽  
W. Sun ◽  
H. Kurihara ◽  
...  
Keyword(s):  
Purkinje Cells ◽  
Motor Coordination ◽  
Climbing Fiber ◽  
Cerebellar Purkinje Cells
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