Development of the blood-brain barrier to horseradish peroxidase in the chick embryo

1978 ◽  
Vol 195 (2) ◽  
Author(s):  
Susumu Wakai ◽  
Nobutaka Hirokawa
Keyword(s):  
Chick Embryo ◽  
Horseradish Peroxidase ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

Effect of atrial natriuretic factor on blood–brain barrier permeability

1989 ◽  
Vol 67 (6) ◽  
pp. 637-640 ◽  
Author(s):  
Sukriti Nag ◽  
Stephen C. Pang
Keyword(s):  
Horseradish Peroxidase ◽  
Blood Brain Barrier ◽  
Atrial Natriuretic Factor ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Natriuretic Factor ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Atrial Natriuretic

Recent studies have demonstrated receptors for atrial natriuretic factor on endothelium of intracerebral vessels. The physiological role of these receptors is not known. The present study was undertaken to determine whether atrial natriuretic factor has an effect on blood–brain barrier permeability to protein and ions using horseradish peroxidase and lanthanum as markers of permeability alterations. This study does not demonstrate a significant effect of atrial natriuretic factor on blood–brain barrier permeability mechanisms in steady states.Key words: blood–brain barrier, atrial natriuretic factor, horseradish peroxidase, lanthanum, ultrastructure.

Effects of 6-aminonicotinamide gliotoxin on blood-brain barrier differentiation in the chick embryo cerebellum

2003 ◽  
Vol 207 (3) ◽  
pp. 209-219 ◽  
Author(s):  
Mirella Bertossi ◽  
Francesco Girolamo ◽  
Mariella Errede ◽  
Daniela Virgintino ◽  
Luisa Roncali
Keyword(s):  
Chick Embryo ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain

O2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins

1986 ◽  
Vol 251 (4) ◽  
pp. H693-H699 ◽  
Author(s):  
E. P. Wei ◽  
M. D. Ellison ◽  
H. A. Kontos ◽  
J. T. Povlishock
Keyword(s):  
Horseradish Peroxidase ◽  
Blood Brain Barrier ◽  
Topical Application ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Blood Brain Barrier Permeability ◽  
Cranial Window ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Pial Arterioles

We studied the effect of topical application of arachidonate on the brain surface on blood-brain barrier permeability to either 125I-labeled human albumin or to horseradish peroxidase administered intravenously. Arachidonate was applied under a cranial window, and the concentration of albumin was measured in brain after elimination of the blood by perfusion-fixation. Permeability to 125I-labeled albumin was increased in the superficial 4 mm of the cortex but not in the deeper cortical layer 4-6 mm from the surface. This increased permeability to albumin was prevented by simultaneous topical application of superoxide dismutase (60 U/ml) and catalase (40 U/ml). Alterations in vascular permeability to horseradish peroxidase were evaluated in semiquantitative fashion, and they behaved similarly. Extravasated horseradish peroxidase was found in the wall of penetrating arterioles, and to a lesser extent in the wall of intraparenchymal vessels and capillaries, but not in the wall of pial arterioles or veins, although these latter vessels displayed focal endothelial lesions. We conclude that arachidonate increases the blood-brain barrier permeability to proteins. This increase in permeability is mediated by O2 radicals. The increased permeability occurs primarily in penetrating arterioles and not in pial arterioles or veins.

scholarly journals Pharmacological Modification of Blood-Brain Barrier Permeability Following a Cold Lesion

1984 ◽  
Vol 11 (4) ◽  
pp. 447-451 ◽  
Author(s):  
Jennifer J. Raymond ◽  
David M. Robertson ◽  
Henry B. Dinsdale ◽  
Sukriti Nag
Keyword(s):  
Horseradish Peroxidase ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Permeability ◽  
Cold Lesion ◽  
Blood Brain ◽  
Brain Barrier Permeability ◽  
Contralateral Cortex ◽  
Bbb Permeability ◽  
Pharmacological Modification

ABSTRACTThe effect of desipramine, imidazole, thioridazine and trifluoperazine on blood-brain barrier(BBB) permeability after a 24 hour cold lesion was studied in rats. Changes in BBB permeability were determined using a quantitative horseradish peroxidase (HRP) assay. The four drugs tested did not alter the quantity of HRP in the cortex of control animals, or in the contralateral cortex of test animals. However, imidazole, desipramine and trifluoperazine significantly reduced the HRP extravasation in and around the cold lesion. Several mechanisms for this effect are suggested; one possible mechanism common to all these drugs is the reduction of increased vesicular transport in cortical vessels adjacent to the cold lesions.

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