Nucleus basalis magnocellularis: optimal coordinates for selective reduction of choline acetyltransferase in frontal neocortex by ibotenic acid injections

1984 ◽  
Vol 56 (2) ◽  
Author(s):  
G.L. Wenk ◽  
B. Cribbs ◽  
L. McCall
Keyword(s):  
Choline Acetyltransferase ◽  
Selective Reduction ◽  
Ibotenic Acid ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis

Effects of altered cholinergic function on working and reference memory in the rat

1986 ◽  
Vol 64 (3) ◽  
pp. 376-382 ◽  
Author(s):  
Richard J. Beninger ◽  
B. A. Wirsching ◽  
Khem Jhamandas ◽  
Roland J. Boegman ◽  
Sherif R. El-Defrawy
Keyword(s):  
Working Memory ◽  
Choline Acetyltransferase ◽  
Radial Maze ◽  
Cholinergic Neurons ◽  
Reference Memory ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Memory Errors ◽  
Biochemical Assays ◽  
Alternation Task

Many data suggest that the brain's cholinergic neurons participate in the control of memory and it has been suggested that cholinergic systems are involved differentially in working and reference memory. To test this hypothesis the effects on memory of unilateral injections of the neurotoxins, quinolinic acid or kainic acid into the cortically projecting cholinergic cells of the nucleus basalis magnocellularis (nbm) were evaluated. In experiment 1, quinolinate-injected (n = 7) and sham-operated (n = 7) rats were tested in a T-maze alternation task that requires working memory. Lesion rats performed significantly more poorly than shams and subsequent biochemical assays of cortical choline acetyltransferase (CAT) activity revealed significant reductions in the lesion rats. In experiment 2, kainate-injected (n = 9) and sham-operated (n = 8) rats were trained in an eight-arm radial maze with only four arms baited. Lesion rats made significantly more working memory errors (entries into baited arms from which the food had already been collected) than reference memory errors (entries into never baited arms). CAT assays showed that the lesion led to a decrease in cortical CAT with no significant change in hippocampal CAT. The results of these studies support the hypothesis that cholinergic neurons of the basocortical system may be differentially involved in working and reference memory.

Electrolytic and ibotenic acid lesions of the nucleus basalis magnocellularis interrupt long-term retention, but not acquisition of two-way active avoidance, in rats

2002 ◽  
Vol 142 (1) ◽  
pp. 52-66 ◽  
Author(s):  
Anna Vale-Martínez ◽  
Gemma Guillazo-Blanch ◽  
Margarita Martí-Nicolovius ◽  
Roser Nadal ◽  
Rosa Arévalo-García ◽  
...  
Keyword(s):  
Active Avoidance ◽  
Ibotenic Acid ◽  
Nucleus Basalis ◽  
Nucleus Basalis Magnocellularis ◽  
Term Retention ◽  
Long Term Retention
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