Pharmacological properties of the postsynaptic inhibition by Purkinje cell axons and the action of ?-aminobutyric acid on Deiters neurones

1967 ◽  
Vol 4 (1) ◽  
Author(s):  
K. Obata ◽  
M. Ito ◽  
R. Ochi ◽  
N. Sato
Keyword(s):  
Purkinje Cell ◽  
Aminobutyric Acid ◽  
Pharmacological Properties ◽  
Postsynaptic Inhibition ◽  
Deiters Neurones

The physiological properties and therapeutic potential of α5-GABAA receptors

2009 ◽  
Vol 37 (6) ◽  
pp. 1334-1337 ◽  
Author(s):  
Loren J. Martin ◽  
Robert P. Bonin ◽  
Beverley A. Orser
Keyword(s):  
Science Fiction ◽  
Gabaa Receptors ◽  
Therapeutic Potential ◽  
Memory Performance ◽  
Aminobutyric Acid ◽  
Pharmacological Properties ◽  
Physiological Properties ◽  
Drug Treatments ◽  
Subtype A ◽  
Memory Enhancing

The notion that drug treatments can improve memory performance has moved from the realm of science fiction to that of serious investigation. A popular working hypothesis is that cognition can be improved by altering the balance between excitatory and inhibitory neurotransmission. This review focuses on the unique physiological and pharmacological properties of GABAARs [GABA (γ-aminobutyric acid) subtype A receptors] that contain the α5 subunit (α5-GABAAR), as these receptors serve as candidate targets for memory-enhancing drugs.

scholarly journals The Effect of the GABA-A Agonist THIP on Regional Cortical Blood Flow in Humans. A New Test of Hemispheric Dominance

1988 ◽  
Vol 8 (3) ◽  
pp. 314-323 ◽  
Author(s):  
Per E. Roland ◽  
Lars Friberg
Keyword(s):  
Internal Carotid ◽  
Water Soluble ◽  
Aminobutyric Acid ◽  
Hemispheric Dominance ◽  
Synaptic Inhibition ◽  
Postsynaptic Inhibition ◽  
Gaba A ◽  
Baseline Levels ◽  
Superior Frontal Cortex

We studied the effect of a γ-aminobutyric acid (GABA)–A receptor–induced postsynaptic inhibition on regional CBF (rCBF) in awake humans. For this purpose we used a new specific GABA–A agonist, 4,5,6,7-tetrahydroisoxazolo(5,4)-pyridin-3-ol (THIP). As part of a new diagnostic procedure for the determination of which hemisphere subserved language, THIP was infused into the internal carotid artery 20 s before measurement of the rCBF. Administered by this route the THIP is distributed to the neocortex and neostriatum. THIP induced a dosage-dependent decrease of the rCBF. The rCBF decrease was not due to any direct effect on the cerebral vessels. The efficiency of the THIP-induced postsynaptic inhibition was tested by having the subjects voluntarily activate the inhibited cortex. During submaximal inhibition the subjects were able voluntarily to counteract decreases of rCBF in superior frontal cortex and motor cortex. Larger doses of THIP abolished this response and depressed the rCBF to baseline levels (20 ml/100 g/min). This was associated with 10-min total depression of function of the anterior two-thirds of the injected hemisphere. An analysis of the changes of rCBF in activated and nonactivated cortex—with and without THIP-induced inhibition—showed that it would be very unlikely that average increases in synaptic inhibition would increase rCBF in neocortical areas. Intracarotid injection of the water-soluble, nonirritative THIP is a very useful alternative to sodium amytal injection for determination of hemispheric dominance.

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