?-endorphin and adrenocorticotropic hormone production during marathon and incremental exercise

1993 ◽  
Vol 66 (3) ◽  
pp. 269-274 ◽  
Author(s):  
H.-Ch. Heitkamp ◽  
K. Schmid ◽  
K. Scheib
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Incremental Exercise ◽  
Hormone Production

Adrenocorticotropin Production by a Mammary Carcinoma

1977 ◽  
Vol 35 ◽  
pp. 462-463
Author(s):  
K.S. McCarty ◽  
N.R. Wallace ◽  
W. Litaker ◽  
S. Wells ◽  
G. Eisenbarth
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Small Cell ◽  
Hormone Production ◽  
Carcinoma Of The Breast ◽  
Ectopic Acth ◽  
Ultrastructural Studies ◽  
Subcutaneous Metastases ◽  
Ectopic Acth Production ◽  
The Right ◽  
Pituitary Carcinomas

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.

scholarly journals Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells

2017 ◽  
Vol Volume 10 ◽  
pp. 4329-4338 ◽  
Author(s):  
Yuko Asari ◽  
Kazunori Kageyama ◽  
Yuki Nakada ◽  
Mizuki Tasso ◽  
Shinobu Takayasu ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Inhibitory Effects ◽  
Hormone Production ◽  
Jak2 Inhibitor

scholarly journals ACTH-PRODUCING PERIPHERAL PULMONARY CARCINOID

2018 ◽  
Vol 99 (4) ◽  
pp. 211-215
Author(s):  
I. Z. Korobkova ◽  
D. A. Dremin ◽  
S. M. Kacalov ◽  
I. V. Kirsan ◽  
A. A. Ugrimov ◽  
...  
Keyword(s):  
Neuroendocrine Tumors ◽  
Adrenocorticotropic Hormone ◽  
Imaging Techniques ◽  
Diagnostic Algorithm ◽  
Integrated Approach ◽  
Hormone Production ◽  
Pulmonary Carcinoid ◽  
Topical Diagnosis ◽  
Acth Secreting ◽  
Rule Out

The paper describes a clinical example of the topical diagnosis of adrenocorticotropic hormone (ACTH)-producing typical peripheral pulmonary carcinoid. The first stage in its diagnosis was to rule out the production of ACTH by the pituitary gland. The paper presents information on the most common localization of functioning neuroendocrine tumors, as well as a diagnostic algorithm to search for an ectopic focus of the ACTH-secreting tumor that causes hypercorticism. Taking into account that bronchopulmonary neuroendocrine tumors with ectopic hormone production occur rarely (5%), a clinical example is given to demonstrate the capabilities of imaging techniques and standards for their implementation using an integrated approach.

scholarly journals Synchronous aldosterone- and cortisol-producing adrenocortical adenomas diagnosed using CYP11B immunohistochemistry

2019 ◽  
Vol 7 ◽  
pp. 2050313X1988377
Author(s):  
Adam Stenman ◽  
Ivan Shabo ◽  
Annica Ramström ◽  
Jan Zedenius ◽  
Carl Christofer Juhlin
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Histopathological Diagnosis ◽  
Hormone Production ◽  
Postoperative Evaluation ◽  
Clinical Routine ◽  
Adrenocortical Adenomas ◽  
Adrenocortical Hyperplasia ◽  
Clinical Consequences ◽  
Autonomous Cortisol Secretion

Immunohistochemistry with antibodies targeting enzymes responsible for the final conversion steps of cortisol (CYP11B1) and aldosterone (CYP11B2) is gaining ground as an adjunct tool in the postoperative evaluation of adrenocortical nodules. The method allows the pathologist to visualize hormone production for each lesion, thereby permitting a more exact assessment regarding the distinction between adrenocortical adenomas and adrenocortical hyperplasia, with implications for patient follow-up. We describe how immunohistochemistry facilitated the histopathological diagnosis of twin adenoma (one cortisol- and one aldosterone-producing) from suspected hyperplasia in a patient with hypertension, mild autonomous cortisol secretion and concurrent adrenocorticotropic hormone–producing adrenomedullary hyperplasia. As the nodules were similar in size and displayed rather analogous histology, CYP11B1 and B2 immunohistochemistry was needed to exclude adrenocortical hyperplasia, allowing us to discharge the patient from further surveillance. We conclude that the application of functional immunohistochemistry has direct clinical consequences and advocates the prompt introduction of these markers in clinical routine.

Inhibition of Adrenocorticotropic Hormone Production by Glucocorticoids in Mouse Pituitary Tumor Cells1

Endocrinology ◽  
1973 ◽  
Vol 93 (2) ◽  
pp. 411-416 ◽  
Author(s):  
HIROKO WATANABE ◽  
WENDELL E. NICHOLSON ◽  
DAVID N. ORTH
Keyword(s):  
Pituitary Tumor ◽  
Adrenocorticotropic Hormone ◽  
Hormone Production ◽  
Mouse Pituitary
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