Antiproliferative activity of 2-[N,N-bis-2-chloroethyl}-amino]-4-[2-sulfonato-ethylthio]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide cyclohexamine (ASIA Z 7557, INN mafosfamide) against human and murine tumor cells in vitro

1984 ◽  
Vol 2 (2) ◽  
Author(s):  
JohnS. Kovach ◽  
PhyllisA. Svingen
Keyword(s):  
Tumor Cells ◽  
Antiproliferative Activity ◽  
Murine Tumor ◽  
Murine Tumor Cells

Echinococcus multilocularis: In vitro secretion of antigen by hybridomas from metacestode germinal cells and murine tumor cells

1989 ◽  
Vol 68 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Angela Dieckmann-Schuppert ◽  
Andreas Ruppel ◽  
Reinhard Burger ◽  
Werner Frank
Keyword(s):  
Tumor Cells ◽  
Echinococcus Multilocularis ◽  
Murine Tumor ◽  
Germinal Cells ◽  
Murine Tumor Cells

Inhibitory Effect of Gramicidin S on the Growth of Murine Tumor Cells in vitro and in vivo

Oncology ◽  
1984 ◽  
Vol 41 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Kouji Okamoto ◽  
Yoshifumi Tomita ◽  
Hiroo Yonezawa ◽  
Tomio Hirohata ◽  
Ryohei Ogura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Inhibitory Effect ◽  
Murine Tumor ◽  
Gramicidin S ◽  
Murine Tumor Cells

Arabinosyladenine and arabinosylhypoxanthine metabolism in murine tumor cells

1970 ◽  
Vol 48 (1) ◽  
pp. 75-78 ◽  
Author(s):  
G. A. LePage
Keyword(s):  
Tumor Cells ◽  
Dna Polymerase ◽  
Antiviral Agent ◽  
In Vitro Metabolism ◽  
Free Base ◽  
Ascites Tumor ◽  
Murine Tumor ◽  
Murine Tumor Cells

The in vitro metabolism of 9-β-D-arabinofuranosyladenine (Ara-A) in TA3 ascites tumor cells was examined and compared with that of its metabolite 9-β-D-arabinofuranosylhypoxanthine (Ara-H). Some evidence for reamination of Ara-H to Ara-A was obtained. Such reamination may explain its activity as an antiviral agent. Unlike Ara-A, Ara-H was not phosphorylated and it did not inhibit DNA polymerase. Incorporation of radioactivity from Ara-A-14C or Ara-H-14C into RNA occurred, but was shown to have proceeded by a cleavage to free base and efficient reutilization of the labeled base.

Inhibitory effects of canthaxanthin on in vitro growth of murine tumor cells

1992 ◽  
Vol 65 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Dennis S. Huang ◽  
Olalekan E. Odeleye ◽  
Ronald R. Watson
Keyword(s):  
Tumor Cells ◽  
In Vitro Growth ◽  
Inhibitory Effects ◽  
Murine Tumor ◽  
Murine Tumor Cells

scholarly journals Synthesis and Evaluation of the Antitumor Activity of Novel 1-(4-Substituted phenyl)-2-ethyl Imidazole Apoptosis Inducers In Vitro

Molecules ◽  
2020 ◽  
Vol 25 (18) ◽  
pp. 4293
Author(s):  
Zhen-Wang Li ◽  
Chun-Yan Zhong ◽  
Xiao-Ran Wang ◽  
Shi-Nian Li ◽  
Chun-Yuan Pan ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Cells ◽  
Antiproliferative Activity ◽  
Antitumor Agent ◽  
Positive Control ◽  
Selectivity Index ◽  
Time Dependent ◽  
Potential Candidate ◽  
Dependent Manner

Novel imidazole derivatives were designed, prepared, and evaluated in vitro for antitumor activity. The majority of the tested derivatives showed improved antiproliferative activity compared to the positive control drugs 5-FU and MTX. Among them, compound 4f exhibited outstanding antiproliferative activity against three cancer cell lines and was considerably more potent than both 5-FU and MTX. In particular, the selectivity index indicated that the tolerance of normal L-02 cells to 4f was 23–46-fold higher than that of tumor cells. This selectivity was significantly higher than that exhibited by the positive control drugs. Furthermore, compound 4f induced cell apoptosis by increasing the protein expression levels of Bax and decreasing those of Bcl-2 in a time-dependent manner. Therefore, 4f could be a potential candidate for the development of a novel antitumor agent.

Expression of Ly-6, a marker for highly malignant murine tumor cells, is regulated by growth conditions and stress

1998 ◽  
Vol 77 (2) ◽  
pp. 306-313 ◽  
Author(s):  
Alexandra Treister ◽  
Orit Sagi-Assif ◽  
Michal Meer ◽  
Nechama I. Smorodinsky ◽  
Romema Anavi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Growth Conditions ◽  
Murine Tumor ◽  
Murine Tumor Cells
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