Aldosterone and thyroid hormone modulation of ?1-, ?1-mRNA, and Na,K-Pump sites in rabbit distal colon epithelium. Evidence for a novel mechanism of escape from the effect of hyperaldosteronemia

1993 ◽  
Vol 133 (3) ◽  
Author(s):  
Hubert Wiener ◽  
JesperM. Nielsen ◽  
DanA. Klaerke ◽  
PeterL. J�rgensen
1978 ◽  
Vol 176 (3) ◽  
pp. 1007-1010 ◽  
Author(s):  
Y Giudicelli

Adipocytes from thyroidectomized rats contain 3 times less [3H]dihydroalprenolol-binding sites (beta-adrenergic receptors) than adipocytes from euthyroid animals. This alteration is not solely due to cell-size differences, but also to a thyroidectomy-induced defect in beta-adrenergic receptor density per adipocyte surface area, a defect that is furthermore corrected by tri-iodothyronine treatment.


1991 ◽  
Vol 260 (4) ◽  
pp. C750-C755 ◽  
Author(s):  
T. R. Traynor ◽  
S. M. O'Grady

Porcine distal colon epithelium was mounted in Ussing chambers and bathed with porcine Ringer solution. The serosal addition of brain natriuretic peptide (BNP; 50 nM) or atriopeptin III (AP-III; 500 nM) produced significant increases (50-75 microA/cm2) in short-circuit current (Isc). These increases in Isc were not inhibited by pretreatment with tetrodotoxin (TTX) or 5,8,11,14-eicosatetraynoic acid (ETYA). Analysis of concentration-response relationships revealed that BNP was 5.8-fold more potent than AP-III in stimulating the Isc. BNP and AP-III significantly increased the serosal-to-mucosal (S----M) Cl flux and reduced net Cl absorption by 38 and 41%, respectively. The BNP-stimulated S----M Cl flux was abolished when HCO3 was removed. In contrast, the vasoactive intestinal peptide (VIP)-stimulated S----M Cl flux was not affected by HCO3 replacement. In addition to their effects on Cl transport, BNP and AP-III increased net Rb secretion by 79 and 58%, respectively. BNP-stimulated Rb secretion was reduced by 76% after HCO3 replacement. These results indicate that natriuretic peptides stimulate K- and HCO3-dependent Cl secretion which is not present under basal conditions or after VIP stimulation. The difference in potency between BNP and AP-III suggests that ANP-B receptors may mediate their effects on ion transport in the porcine colon.


2010 ◽  
Vol 6 (4) ◽  
pp. 339-347 ◽  
Author(s):  
Ana M. Genaro ◽  
Alicia J. Klecha ◽  
Luciana R. Frick ◽  
Maria L. Barreiro Arcos ◽  
Graciela A. Cremaschi

1998 ◽  
Vol 86 (6) ◽  
pp. 1187-1193 ◽  
Author(s):  
Roberto Imberti ◽  
Mariapia Vairetti ◽  
Maria Rita Gualea ◽  
Fausto Feletti ◽  
Giuseppe Poma ◽  
...  

2019 ◽  
Vol 21 (5) ◽  
pp. 231-246 ◽  
Author(s):  
Demi Galindo ◽  
Elly Sweet ◽  
Zoey DeLeon ◽  
Mitchel Wagner ◽  
Adrian DeLeon ◽  
...  

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