Increased platelet sodium-proton exchange rates in insulin-dependent (type 1) diabetic patients with nephropathy and hypertension

1992 ◽  
Vol 109 (2) ◽  
Author(s):  
Pierre Barbe ◽  
Jean-Pierre Salles ◽  
Philippe Barthe ◽  
Jean-Pierre Louvet ◽  
Hugues Chap
Keyword(s):  
Exchange Rates ◽  
Proton Exchange ◽  
Diabetic Patients ◽  
Sodium Proton Exchange ◽  
Insulin Dependent ◽  
Type 1 Diabetic Patients ◽  
Dependent Type

Measurement of whole-body protein turnover in insulin-dependent (type 1) diabetic patients during insulin withdrawal and infusion: comparison of [13C]leucine and [2H5]phenylalanine methodologies

1991 ◽  
Vol 80 (4) ◽  
pp. 345-352 ◽  
Author(s):  
P. J. Pacy ◽  
G. N. Thompson ◽  
D. Halliday
Keyword(s):  
Protein Turnover ◽  
Insulin Infusion ◽  
Whole Body ◽  
Diabetic Patients ◽  
Body Protein ◽  
Insulin Withdrawal ◽  
Insulin Dependent ◽  
Type 1 Diabetic Patients ◽  
Dependent Type

1. The aims of this study were twofold: (i) to investigate the ability of a recently described [2H5]phenylalanine method for quantifying whole-body protein turnover during acute physiological perturbation; (ii) to determine specifically whether the previously observed increase in protein synthesis on insulin withdrawal in insulin-dependent (type 1) diabetic patients seen when employing the [13C]leucine technique could be corroborated by using [2H5]phenylalanine. 2. Whole-body protein turnover was measured by both the [2H5]phenylalanine and [13C]leucine primed continuous infusion methods applied simultaneously to six type I post-absorptive diabetic patients during insulin withdrawal and infusion. 3. Values were determined by the [13C]leucine method by measuring either [13C]leucine (primary pool) or α-[13C]ketoisocaproic acid (reciprocal pool) enrichment in plasma. 4. Values of whole-body protein breakdown during insulin withdrawal derived from the [2H5]phenylalanine and primary and reciprocal pool [13C]leucine models respectively were 3.54 ± 0.43, 3.85 ± 0.41 and 4.62 ± 0.44 g day−1 kg−1 (means ± SD). Insulin infusion resulted in a significant reduction (P <0.02) to 3.07 ± 0.34, 3.05 ± 0.26 and 3.82 ± 0.4 g day−1 kg−1, respectively. Synthesis values fell significantly but by a smaller amount than breakdown, resulting in increased (P <0.05) net protein deposition, regardless of the model used. 5. These data demonstrate that the [2H5]phenylalanine and [13C]leucine methods generate similar results both in absolute and relative terms in response to short-term insulin infusion. 6. The confirmation of increased whole-body protein synthesis during insulin withdrawal by two independent methods supports the validity of this observation.

Decreased distensibility of resistance vessels of the skin in type 1 (insulin-dependent) diabetic patients with microangiopathy

1987 ◽  
Vol 72 (1) ◽  
pp. 123-130 ◽  
Author(s):  
J. Kastrup ◽  
T. Nørgaard ◽  
H.-H. Parving ◽  
N. A. Lassen
Keyword(s):  
Blood Flow ◽  
Inverse Correlation ◽  
Diabetic Patients ◽  
Resistance Vessels ◽  
Head Up Tilt ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Type 1 Diabetic Patients ◽  
Term Type

1. The distensibility of the resistance vessels of the skin at the dorsum of the foot was determined in 11 long-term type 1 (insulin-dependent) diabetic patients with nephropathy and retinopathy, nine short-term type 1 diabetic patients without clinical microangiopathy and in nine healthy non-diabetic subjects. 2. Blood flow was measured by the local 133Xexenon washout technique in a vascular bed locally paralysed by the injection of histamine. Blood flow was measured before, during and after a 40 mmHg increase of the vascular transmural pressure, induced by head-up tilt. 3. The mean increase in blood flow during headup tilt was only 24% in diabetic subjects with and 48% in diabetic patients without clinical microangiopathy, compared with 79% in normal non-diabetic subjects (P < 0.0005 and P < 0.05, respectively). 4. An inverse correlation between microvascular distensibility and degree of hyalinosis of the terminal arterioles in biopsies from the skin was demonstrated (r = − 0.57, P < 0.001). 5. Our results suggest that terminal arteriolar hyalinosis reduces the microvascular distensibility and probably increases the minimal vascular resistance, thereby impeding hyperaemic responses.

scholarly journals Species-Specific Autoantibodies in Type 1 Diabetes1

1999 ◽  
Vol 84 (2) ◽  
pp. 643-648
Author(s):  
C. S. Hampe ◽  
E. Örtqvist ◽  
O. Rolandsson ◽  
M. Landin-Olsson ◽  
C. Törn ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Age At Onset ◽  
Insulin Dependent Diabetes Mellitus ◽  
Positive Control ◽  
Dependent Diabetes Mellitus ◽  
Diabetic Patients ◽  
Insulin Dependent ◽  
Species Specific ◽  
Type 1 Diabetic Patients

GAD65 autoantibodies (GAD65Ab) are important markers for type 1 (insulin-dependent) diabetes mellitus. Although most patients have GAD65Ab at the time of clinical diagnosis, there are also GAD65Ab-positive individuals in the population at low risk of developing type 1 diabetes. The aim of this study was to test the hypothesis that the GAD65Ab reactivity to GAD65 cloned from human, mouse, and rat in newly diagnosed type 1 diabetic patients differ from antibody-positive healthy individuals. Sera from 254 new-onset 0- to 34-yr-old type 1 diabetic patients and 270 controls were assayed for their reactivity to human, mouse, and rat GAD65. Among the type 1 diabetic patients there was a significant better binding of human GAD65 compared to either mouse (P = 0.03) or rat GAD65 (P = 0.0005). The preference for human GAD65 increased with increasing age at onset (P = 0.0002). This differentiation was not observed in 88 GAD65Ab-positive control subjects. Our data indicate that recognition of epitopes by GAD65Ab in type 1 diabetes is different from that in nontype 1 diabetes, GAD65Ab-positive individuals.

Is there a relationship between body composition and insulin regimen modality in type 1 diabetic patients?

2014 ◽  
Author(s):  
Merve Yilmaz ◽  
Arzu Gedik ◽  
Simge Yilmaz ◽  
Belgin Bektas ◽  
Dilek Cimrin ◽  
...  
Keyword(s):  
Body Composition ◽  
Diabetic Patients ◽  
Insulin Regimen ◽  
Type 1 Diabetic Patients

Insulin-mimetic effects of short-term Rapamycin in type 1 diabetic patients prior islet transplantation

2017 ◽  
Author(s):  
Federica Ermetici ◽  
Silvia Briganti ◽  
Stefano Benedini ◽  
Roberto Codella ◽  
Paola Maffi ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Diabetic Patients ◽  
Short Term ◽  
Insulin Mimetic ◽  
Type 1 Diabetic Patients

Products of therapeutic insulins in the blood of insulin-dependent (type I) diabetic patients

Diabetes ◽  
1985 ◽  
Vol 34 (5) ◽  
pp. 510-519 ◽  
Author(s):  
D. C. Robbins ◽  
S. E. Shoelson ◽  
H. S. Tager ◽  
P. M. Mead ◽  
D. H. Gaynor
Keyword(s):  
Diabetic Patients ◽  
Type I ◽  
Insulin Dependent ◽  
Dependent Type

GENETIC ROLE OF HLA-G14 BASE PAIR INDEL POLYMORPHIC GENE WITH TYPE 1 DIABETIC PATIENTS

2019 ◽  
Vol 22 (09) ◽  
pp. 154-160
Author(s):  
Hasanain Khaleel Shareef ◽  
Ahmed Adil Ali ◽  
Rafah F. Al-Jebori
Keyword(s):  
Base Pair ◽  
Diabetic Patients ◽  
Polymorphic Gene ◽  
Type 1 Diabetic Patients
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