Monoclonal antibody 473 selectively stains a population of GABAergic neurons containing the calcium-binding protein parvalbumin in the rat cerebral cortex

1992 ◽  
Vol 89 (1) ◽  
Author(s):  
Toshio Kosaka ◽  
ClausW. Heizmann ◽  
ShinobuC. Fujita
Keyword(s):  
Monoclonal Antibody ◽  
Cerebral Cortex ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Gabaergic Neurons ◽  
Rat Cerebral Cortex

Immunohistochemical localization of S100 beta in human nervous system tumors by using monoclonal antibodies with specificity for the S100 beta polypeptide.

1986 ◽  
Vol 34 (8) ◽  
pp. 977-982 ◽  
Author(s):  
L J Van Eldik ◽  
R A Jensen ◽  
B A Ehrenfried ◽  
W O Whetsell
Keyword(s):  
Monoclonal Antibody ◽  
Nervous System ◽  
Monoclonal Antibodies ◽  
Calcium Binding ◽  
Binding Protein ◽  
Immunohistochemical Localization ◽  
Calcium Binding Protein ◽  
Nervous System Tumors ◽  
Human Nervous System

The immunohistochemical localization of the calcium-binding protein, S100 beta, in human nervous system tumors has been examined by using a monoclonal antibody with specificity for the S100 beta polypeptide. S100 beta-specific immunoreactivity is detected in astrocytoma, glioblastoma, Schwannoma, ependymoma, and craniopharyngioma, whereas no reactivity is seen in oligodendroglioma, meningioma, neuroblastoma, or medulloblastoma. These data suggest that analysis of S100 beta localization with these monoclonal antibodies may be useful for research or diagnostic purposes.

scholarly journals Neutrophilic Cell-Free Exudate Induces Antinociception Mediate by the Protein S100A9

2006 ◽  
Vol 2006 ◽  
pp. 1-6 ◽  
Author(s):  
Rosana L. Pagano ◽  
Mario Mariano ◽  
Renata Giorgi
Keyword(s):  
Monoclonal Antibody ◽  
Calcium Binding ◽  
Inflammatory Pain ◽  
Initial Phase ◽  
Binding Protein ◽  
Antinociceptive Effect ◽  
Calcium Binding Protein ◽  
Nociceptive Response ◽  
Endogenous Control

Calcium-binding protein S100A9 (MRP-14) induces antinociceptive effect in an experimental model of painful sensibility and participates of antinociception observed during neutrophilic peritonitis induced by glycogen or carrageenan in mice. In this study, the direct antinociceptive role of the protein S100A9 in neutrophilic cell-free exudates obtained of mice injected with glycogen was investigated. Mice were intraperitoneally injected with a glycogen solution, and after4,8,24, and48hours, either the pattern of cell migration of the peritoneal exudate or the nociceptive response of animals was evaluated. The glycogen-induced neutrophilic peritonitis evoked antinociception4and8hours after inoculation of the irritant. Peritoneal cell-free exudates, collected in different times after the irritant injection, were transferred to naive animals which were submitted to the nociceptive test. The transference of exudates also induced antinociceptive effect, and neutralization of S100A9 activity by anti-S100A9 monoclonal antibody totally reverted this response. This effect was not observed when experiments were made24or48hours after glycogen injection. These results clearly indicate that S100A9 is secreted during glycogen-induced neutrophilic peritonitis, and that this protein is responsible by antinociception observed in the initial phase of inflammatory reaction. Thus, these data reinforce the hypothesis that the calcium-binding protein S100A9 participates of the endogenous control of inflammatory pain.

scholarly journals Changes in density of calcium-binding-protein-immunoreactive GABAergic neurons in prefrontal cortex in schizophrenia and bipolar disorder

2008 ◽  
Vol 28 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Tsutomu Sakai ◽  
Akihiko Oshima ◽  
Yusuke Nozaki ◽  
Itsuro Ida ◽  
Chie Haga ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Prefrontal Cortex ◽  
Calcium Binding ◽  
Binding Protein ◽  
Calcium Binding Protein ◽  
Gabaergic Neurons
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