Sex differences in GABA/benzodiazepine receptor changes and corticosterone release after acute stress in rats

1994 ◽  
Vol 101 (2) ◽  
pp. 297-306 ◽  
Author(s):  
Marlene A. Wilson ◽  
Rosemary Biscardi
Keyword(s):  
Sex Differences ◽  
Acute Stress ◽  
Benzodiazepine Receptor ◽  
Corticosterone Release

scholarly journals Sex differences in the effects of acute stress on behavior in the ultimatum game

2018 ◽  
Vol 96 ◽  
pp. 126-131 ◽  
Author(s):  
Farid F. Youssef ◽  
Raecho Bachew ◽  
Satyavi Bissessar ◽  
Molly J. Crockett ◽  
Nadira S. Faber
Keyword(s):  
Sex Differences ◽  
Acute Stress ◽  
Ultimatum Game

scholarly journals Diazepam-binding inhibitor/acyl-CoA-binding protein mRNA and peripheral benzodiazepine receptor mRNA in endocrine and immune tissues after prenatal diazepam exposure of male and female rats

2000 ◽  
Vol 166 (1) ◽  
pp. 163-171 ◽  
Author(s):  
B Burgi ◽  
W Lichtensteiger ◽  
M Schlumpf
Keyword(s):  
Sex Differences ◽  
Mrna Expression ◽  
Binding Protein ◽  
Benzodiazepine Receptor ◽  
Female Offspring ◽  
Female Rats ◽  
Drug Induced ◽  
Immune Organs ◽  
Male And Female Rats ◽  
Immune Tissues

Peripheral benzodiazepine (BDZ) receptor (PBR) and diazepam-binding inhibitor/acyl-CoA-binding protein (DBI/ACBP) characterized as a ligand at central BDZ receptors, at PBR with involvement in the regulation of steroidogenesis, and as an intracellular acyl-CoA transporter, are both known to interact with BDZ in adult systems. We investigated their expression after prenatal exposure to BDZ. Diazepam (1.25 mg/kg per day s.c.) was administered to time-pregnant Long Evans rats from gestational day (GD) 14 to 20. Expression of mRNAs encoding for PBR and for DBI/ACBP was studied in the same animals with (33)P-labeled 60 mer oligonucleotides (oligos) by in situ hybridization at GD20, and with (32)P-labeled oligos by Northern blot in steroidogenic and immune organs at postnatal day (PN) 14 and in adult offspring. Prenatal diazepam increased DBI/ACBP mRNA expression in male fetal adrenal and in fetal and PN14 testis. Thymus exhibited increased DBI/ACBP mRNA in male fetuses and in adult female offspring, and reduced organ weight at PN14 in both sexes. In female spleen, an increase in DBI/ACBP mRNA and a decrease in PBR mRNA was seen at PN14. Apart from the finding in spleen, no drug-induced changes in PBR mRNA were observed. The effects of prenatal diazepam were superimposed on treatment-independent sex differences in DBI/ACBP mRNA and PBR mRNA expression. Our data indicate that expression of DBI/ACBP mRNA in steroidogenic and immune organs can be affected by exposure to BDZ during ontogeny, while PBR mRNA expression appears to be less sensitive. They further reveal marked sex differences in the developmental patterns of the two proteins during pre- and postpubertal ontogeny.

Sex differences, or not, in spatial cognition in albino rats: acute stress is the key

2008 ◽  
Vol 76 (5) ◽  
pp. 1579-1589 ◽  
Author(s):  
Anjanette P. Harris ◽  
Richard B. D'eath ◽  
Susan D. Healy
Keyword(s):  
Sex Differences ◽  
Spatial Cognition ◽  
Acute Stress ◽  
Albino Rats

scholarly journals Molecular diversity of corticotropin-releasing hormone mRNA-containing neurons in the hypothalamus

2017 ◽  
Vol 232 (3) ◽  
pp. R161-R172 ◽  
Author(s):  
Roman A Romanov ◽  
Alán Alpár ◽  
Tomas Hökfelt ◽  
Tibor Harkany
Keyword(s):  
Paraventricular Nucleus ◽  
Acute Stress ◽  
Corticotropin Releasing Hormone ◽  
Hormonal Responses ◽  
Releasing Hormone ◽  
Rapid Induction ◽  
Hypothalamic Nuclei ◽  
Molecular Machinery ◽  
As Stress ◽  
Corticosterone Release

Hormonal responses to acute stress rely on the rapid induction of corticotropin-releasing hormone (CRH) production in the mammalian hypothalamus, with subsequent instructive steps culminating in corticosterone release at the periphery. Hypothalamic CRH neurons in the paraventricular nucleus of the hypothalamus are therefore considered as ‘stress neurons’. However, significant morphological and functional diversity among neurons that can transiently produce CRH in other hypothalamic nuclei has been proposed, particularly as histochemical and molecular biology evidence associates CRH to both GABA and glutamate neurotransmission. Here, we review recent advances through single-cell RNA sequencing and circuit mapping to suggest that CRH production reflects a state switch in hypothalamic neurons and thus confers functional competence rather than being an identity mark of phenotypically segregated neurons. We show that CRH mRNA transcripts can therefore be seen in GABAergic, glutamatergic and dopaminergic neuronal contingents in the hypothalamus. We then distinguish ‘stress neurons’ of the paraventricular nucleus that constitutively express secretagogin, a Ca2+ sensor critical for the stimulus-driven assembly of the molecular machinery underpinning the fast regulated exocytosis of CRH at the median eminence. Cumulatively, we infer that CRH neurons are functionally and molecularly more diverse than previously thought.

scholarly journals Weight loss in rats exposed to repeated acute restraint stress is independent of energy or leptin status

2002 ◽  
Vol 282 (1) ◽  
pp. R77-R88 ◽  
Author(s):  
Ruth B. S. Harris ◽  
Tiffany D. Mitchell ◽  
Jacob Simpson ◽  
Stephen M. Redmann ◽  
Bradley D. Youngblood ◽  
...  
Keyword(s):  
Weight Loss ◽  
Weight Regain ◽  
Acute Stress ◽  
Significant Weight Loss ◽  
Endocrine Response ◽  
Sustained Reduction ◽  
Response To Stress ◽  
Corticosterone Release ◽  
Chronic Change ◽  
Crf System

Acute release of corticotropin-releasing factor (CRF) during repeated restraint (3-h restraint on each of 3 days) causes temporary hypophagia but chronic suppression of body weight in rats. Here we demonstrated that a second bout of repeated restraint caused additional weight loss, but continuing restraint daily for 10 days did not increase weight loss because the rats adapted to the stress. In these two studies serum leptin, which suppresses the endocrine response to stress, was reduced in restrained rats. Peripheral infusion of leptin before and during restraint did not prevent stress-induced weight loss, although stress-induced corticosterone release was suppressed. Restrained rats were hyperthermic during restraint, but there was no evidence that fever or elevated free interleukin-6 caused the sustained reduction in weight. Restraining food-restricted rats caused a small but significant weight loss. Food-restricted rats fed ad libitum after the end of restraint showed a blunted hyperphagia and slower rate of weight regain than their controls. These results indicate that repeated acute stress induces a chronic change in weight independent of stress-induced hypophagia and may represent a change in homeostasis initiated by repeated acute activation of the central CRF system.

The impact of cortisol reactivity to acute stress on memory: Sex differences in middle-aged people

Stress ◽  
2010 ◽  
Vol 14 (2) ◽  
pp. 117-127 ◽  
Author(s):  
Mercedes Almela ◽  
Vanesa Hidalgo ◽  
Carolina Villada ◽  
Laura Espín ◽  
Jesús Gómez-Amor ◽  
...  
Keyword(s):  
Sex Differences ◽  
Acute Stress ◽  
Middle Aged ◽  
Cortisol Reactivity ◽  
Aged People ◽  
The Impact
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