Quantal analysis of long-term potentiation of ?minimal? excitatory postsynaptic potentials in guinea pig hippocampal slices: binomial approach

1992 ◽  
Vol 89 (2) ◽  
Author(s):  
L.L. Voronin ◽  
U. Kuhnt ◽  
A.G. Gusev ◽  
G. Hess
Keyword(s):  
Guinea Pig ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Excitatory Postsynaptic Potentials ◽  
Postsynaptic Potentials ◽  
Term Potentiation ◽  
Quantal Analysis

Long-term potentiation in hippocampal slices induced by temporary suppression of glycolysis

1995 ◽  
Vol 74 (6) ◽  
pp. 2763-2766 ◽  
Author(s):  
S. Tekkok ◽  
K. Krnjevic
Keyword(s):  
Nmda Receptors ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Synaptic Function ◽  
Excitatory Postsynaptic Potentials ◽  
Postsynaptic Potentials ◽  
After Effects ◽  
Population Spikes ◽  
Term Potentiation

1. Temporary suppression of glycolysis by 2-deoxy-D-glucose (2-DG)-long enough to abolish CA1 population spikes (PSs) and reduce field excitatory postsynaptic potentials (EPSPs) by two-thirds-is followed by a sustained rebound of EPSPs and PSs (both up by 70-150%). 2. Post 2-DG long-term potentiation (2-DG-LTP) is prevented by block of N-methyl-D-aspartate (NMDA) receptors (NMDARs). Though 2-DG-LTP is normally expressed by other receptors, in presence of picrotoxin 2-DG causes similar LTP of NMDAR-mediated EPSPs. 3. Stimulation at 1 s-1 fully depotentiates 2-DG-LTP. 4. Unlike tetanic LTP, 2-DG-LTP is not pathway-specific, is not occluded by a preceding tetanic LTP (or vice versa) and is insensitive to block of NO synthesis. 5. Hypoglycemic states may have long-lasting after-effects on cerebral synaptic function.

Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices

1991 ◽  
Vol 555 (1) ◽  
pp. 112-122 ◽  
Author(s):  
Satoshi Fujii ◽  
Kazuo Saito ◽  
Hiroyoshi Miyakawa ◽  
Ken-ichi Ito ◽  
Hiroshi Kato
Keyword(s):  
Guinea Pig ◽  
Hippocampal Slices ◽  
Long Term Potentiation ◽  
Ca1 Neurons ◽  
Term Potentiation ◽  
Stimulation Of
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