Growth hormone stimulates the secretion of insulin-like growth factor binding protein-2 (IGFBP-2) by monolayer cultures of sheep costal growth plate chondrocytes

1996 ◽  
Vol 162 (2) ◽  
Author(s):  
V. Borromeo ◽  
S. Bramani ◽  
A.T. Holder ◽  
C. Carter ◽  
C. Secchi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Growth Plate ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Growth Plate Chondrocytes ◽  
Factor Binding ◽  
Monolayer Cultures

scholarly journals Differential effects of insulin-like growth factor binding proteins-1, -2, -3, and -6 on cultured growth plate chondrocytes

2002 ◽  
Vol 62 (5) ◽  
pp. 1591-1600 ◽  
Author(s):  
Daniela Kiepe ◽  
Tim Ulinski ◽  
David R. Powell ◽  
Susan K. Durham ◽  
Otto Mehls ◽  
...  
Keyword(s):  
Growth Factor ◽  
Growth Plate ◽  
Binding Proteins ◽  
Insulin Like Growth Factor ◽  
Growth Plate Chondrocytes ◽  
Differential Effects ◽  
Factor Binding

Rat ovarian insulin-like growth factor binding protein-3: a growth hormone-dependent theca-interstitial cell-derived antigonadotropin.

Endocrinology ◽  
1992 ◽  
Vol 130 (5) ◽  
pp. 3092-3094 ◽  
Author(s):  
E Ricciarelli ◽  
E R Hernandez ◽  
C Tedeschi ◽  
L F Botero ◽  
E Kokia ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Interstitial Cell ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Growth Inhibition in Giant Growth Hormone Transgenic Mice by Overexpression of Insulin-Like Growth Factor-Binding Protein-2

Endocrinology ◽  
2001 ◽  
Vol 142 (5) ◽  
pp. 1889-1898 ◽  
Author(s):  
Andreas Hoeflich ◽  
Sabine Nedbal ◽  
Werner F. Blum ◽  
Michael Erhard ◽  
Harald Lahm ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Transgenic Mice ◽  
Growth Inhibition ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding

A homologous radioimmunoassay for ovine insulin-like growth factor-binding protein-2: ontogenesis and the response to growth hormone, placental lactogen and insulin-like growth factor-I treatment in sheep

1995 ◽  
Vol 144 (1) ◽  
pp. 75-82 ◽  
Author(s):  
B W Gallaher ◽  
B H Breier ◽  
W F Blum ◽  
S N McCutcheon ◽  
P D Gluckman
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Binding Protein ◽  
Negative Relationship ◽  
Serum Levels ◽  
Treated Group ◽  
Placental Lactogen ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Igf I

Abstract Although insulin-like growth factor-binding protein-2 (IGFBP-2) is an abundant IGFBP in fetal and postnatal plasma, its regulation is not yet clearly understood. To address this question in sheep, we purified ovine IGFBP-2 and developed a homologous radioimmunoassay. We have studied its ontogenesis and measured serum concentrations of ovine IGFBP-2 after bovine growth hormone (bGH), ovine placental lactogen (oPL) and IGF-I treatment. Concentrations of IGFBP-2 were high at 125 days of gestation (550 ± 15 μg/l) but fell after birth P<0·05) and plateaued after 1 year of age (340 ± 20 μg/l). In lactating ewes, bGH treatment for 7 days significantly reduced (21%; P<0·05) IGFBP-2 relative to the saline-treated group. Similarly, in neonatal lambs, bGH treatment from day 3 to day 23 of life reduced (P<0·05) IGFBP-2 by 23% relative to the saline-treated group. oPL had no effect on serum levels of IGFBP-2 in the ewe or the neonatal lamb. In well-fed yearling lambs, treatment with IGF-I reduced IGFBP-2 values by 27% (P<0·05) relative to control animals. In yearling lambs, reduced nutrition increased plasma IGFBP-2 (41%; P<0·05). However this increase was abolished by IGF-I treatment. The changes in plasma levels of IGFBP-2 were positively related to changes in IGF-II while there was a negative relationship between circulating IGF-I and IGFBP-2 such that both IGF-I and IGF-II may play a role in the regulation of IGFBP-2 in serum. Journal of Endocrinology (1995) 144, 75–82

Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3

2016 ◽  
Vol 31 (4) ◽  
pp. 827-835 ◽  
Author(s):  
Ömer Kartal ◽  
Seçil Aydınöz ◽  
Ayşe Tuğba Kartal ◽  
Taha Kelestemur ◽  
Ahmet Burak Caglayan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Binding Protein ◽  
Time Dependent ◽  
Insulin Like Growth Factor ◽  
Perinatal Hypoxia ◽  
Factor Binding
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