Spectral sensitivity of photoreceptors mediating phase-shifts of circadian rhythms in retinally degenerate CBA/J (rd/rd) and normal CBA/N (+/+) mice

1996 ◽  
Vol 178 (6) ◽  
Author(s):  
T. Yoshimura ◽  
S. Ebihara
Keyword(s):  
Circadian Rhythms ◽  
Spectral Sensitivity ◽  
Phase Shifts

Seizures induce phase shifts of rat circadian rhythms

2001 ◽  
Vol 913 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Mark Quigg ◽  
Martin Straume ◽  
Teresa Smith ◽  
Michael Menaker ◽  
Edward H Bertram
Keyword(s):  
Circadian Rhythms ◽  
Phase Shifts ◽  
Induce Phase

Morphine phase-shifts circadian rhythms in mice

Neuroreport ◽  
1995 ◽  
Vol 7 (1) ◽  
pp. 209-212 ◽  
Author(s):  
Elliott G. Marchant ◽  
Ralph E. Mistlberger
Keyword(s):  
Circadian Rhythms ◽  
Phase Shifts

Histamine synthesis inhibition reduces light-induced phase shifts of circadian rhythms

1995 ◽  
Vol 695 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Sara J. Eaton ◽  
Niki K. Cote ◽  
Mary E. Harrington
Keyword(s):  
Circadian Rhythms ◽  
Phase Shifts ◽  
Synthesis Inhibition ◽  
Histamine Synthesis

scholarly journals Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study

2002 ◽  
Vol 282 (2) ◽  
pp. R454-R463 ◽  
Author(s):  
Katherine M. Sharkey ◽  
Charmane I. Eastman
Keyword(s):  
Circadian Rhythms ◽  
Shift Work ◽  
Phase Shifts ◽  
Night Work ◽  
Phase Shifting ◽  
Jet Lag ◽  
Work Study ◽  
Temperature Minimum ◽  
Sleep Schedule ◽  
Dim Light

There has been scant evidence for a phase-shifting effect of melatonin in shift-work or jet-lag protocols. This study tested whether melatonin can facilitate phase shifts in a simulated night-work protocol. Subjects ( n = 32) slept in the afternoons/evenings before night work (a 7-h advance of the sleep schedule). They took melatonin (0.5 mg or 3.0 mg) or placebo before the first four of eight afternoon/evening sleep episodes at a time when melatonin has been shown to phase advance the circadian clock. Melatonin produced larger phase advances than placebo in the circadian rhythms of melatonin and temperature. Average phase advances (±SD) of the dim light melatonin onset were 1.7 ± 1.2 h (placebo), 3.0 ± 1.1 h (0.5 mg), and 3.9 ± 0.5 h (3.0 mg). A measure of circadian adaptation, shifting the temperature minimum enough to occur within afternoon/evening sleep, showed that only subjects given melatonin achieved this goal (73% with 3.0 mg, 56% with 0.5 mg, and 0% with placebo). Melatonin could be used to promote adaptation to night work and jet travel.

The relation between light-induced discharge in the suprachiasmatic nucleus and phase shifts of hamster circadian rhythms

1992 ◽  
Vol 598 (1-2) ◽  
pp. 257-263 ◽  
Author(s):  
Johanna H. Meijer ◽  
Benjamin Rusak ◽  
Gabriëlla Gänshirt
Keyword(s):  
Circadian Rhythms ◽  
Suprachiasmatic Nucleus ◽  
Phase Shifts

Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms

Nature ◽  
1984 ◽  
Vol 308 (5955) ◽  
pp. 186-188 ◽  
Author(s):  
Joseph S. Takahashi ◽  
Patricia J. DeCoursey ◽  
Lisa Bauman ◽  
Michael Menaker
Keyword(s):  
Circadian Rhythms ◽  
Spectral Sensitivity

scholarly journals Pituitary Adenylate Cyclase Activating Peptide Phase Shifts Circadian Rhythms in a Manner Similar to Light

1999 ◽  
Vol 19 (15) ◽  
pp. 6637-6642 ◽  
Author(s):  
Mary E. Harrington ◽  
Sabina Hoque ◽  
Adam Hall ◽  
Diego Golombek ◽  
Stephany Biello
Keyword(s):  
Circadian Rhythms ◽  
Adenylate Cyclase ◽  
Phase Shifts ◽  
Pituitary Adenylate Cyclase

scholarly journals Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN

1988 ◽  
Vol 255 (6) ◽  
pp. R1055-R1058
Author(s):  
S. T. Inouye ◽  
J. S. Takahashi ◽  
F. Wollnik ◽  
F. W. Turek
Keyword(s):  
Protein Synthesis ◽  
Circadian Rhythms ◽  
Activity Rhythm ◽  
Phase Shifts ◽  
Protein Synthesis Inhibitor ◽  
Circadian Pacemaker ◽  
Synthesis Inhibitor ◽  
Anatomic Site ◽  
Site Of Action ◽  
Inhibitor Of Protein Synthesis

The suprachiasmatic nucleus (SCN) of the hypothalamus contains a circadian pacemaker that regulates many circadian rhythms in mammals. Experimental work in microorganisms and invertebrates suggests that protein synthesis is required for the function of the circadian oscillator, and recent experiments in golden hamsters suggest an acute inhibition of protein synthesis can induce phase shifts in a mammalian circadian pacemaker. To determine whether protein synthesis in the SCN region is involved in the generation of circadian rhythms in mammals, a protein synthesis inhibitor, anisomycin, was microinjected into the SCN region, and the effect on the circadian rhythm of locomotor activity of hamsters was measured. A single injection of anisomycin into the SCN region induced phase shifts in the circadian activity rhythm that varied systematically as a function of the phase of injection within the circadian cycle. These results suggest that protein synthesis may be involved in the generation of circadian rhythms in mammals and that the anatomic site of action of anisomycin is within the hypothalamic suprachiasmatic region.

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