Inhibitors of cytoplasmic protein synthesis purified from rat liver mitochondria

1984 ◽  
Vol 62 (2) ◽  
Author(s):  
Jos�Luis P�rez ◽  
Blas Dorta ◽  
Nestor Gonz�lez-Cadavid
Keyword(s):  
Protein Synthesis ◽  
Rat Liver ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Cytoplasmic Protein

scholarly journals Inhibition of protein synthesis by ricin: experiments with rat liver mitochondria and nuclei and with ribosomes from Escherichia coli

1974 ◽  
Vol 142 (3) ◽  
pp. 695-697 ◽  
Author(s):  
Margherita Greco ◽  
Lucio Montanaro ◽  
Francesco Novello ◽  
Cecilia Saccone ◽  
Simonetta Sperti ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Protein Synthesis ◽  
Rat Liver ◽  
Ricinus Communis ◽  
Liver Mitochondria ◽  
Rat Liver Mitochondria ◽  
Isolated Rat Liver ◽  
Liver Nuclei ◽  
Isolated Rat ◽  
Liver Ribosomes

1. Ricin, a toxic protein from the seeds of Ricinus communis which inhibits poly(U)-directed polyphenylalanine synthesis by rat liver ribosomes (Montanaro et al., 1973), does not affect protein synthesis by isolated rat liver mitochondria. 2. The toxin is ineffective also on poly(U)-directed polyphenylalanine synthesis in reconstituted systems with ribosomes isolated from rat liver mitochondria or from Escherichia coli. 3. Ricin inhibits protein synthesis by isolated rat liver nuclei, but at concentrations much higher than those affecting rat liver ribosomes.

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