Localization and function of cyclic guanosine monophosphate-phosphodiesterase activity in the retinal rods of the rat by means of a newly developed cytochemical method

1984 ◽  
Vol 238 (3) ◽  
Author(s):  
Satoki Ueno ◽  
HeinzJoachim Bambauer ◽  
Hikmet Umar ◽  
Manfred Ueck
Keyword(s):  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Phosphodiesterase Activity ◽  
Cytochemical Method ◽  
Retinal Rods ◽  
Cyclic Guanosine Monophosphate Phosphodiesterase ◽  
And Function

Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma

2003 ◽  
Vol 32 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Giuseppe Spoto ◽  
Massimiliano Fioroni ◽  
Corrado Rubini ◽  
Alessandro Contento ◽  
Maurizio Di Nicola ◽  
...  
Keyword(s):  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Phosphodiesterase Activity ◽  
Cyclic Guanosine Monophosphate Phosphodiesterase

scholarly journals cGMP: a unique 2nd messenger molecule – recent developments in cGMP research and development

2019 ◽  
Vol 393 (2) ◽  
pp. 287-302 ◽  
Author(s):  
Andreas Friebe ◽  
Peter Sandner ◽  
Achim Schmidtko
Keyword(s):  
Guanylyl Cyclase ◽  
Soluble Guanylyl Cyclase ◽  
Cell Types ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Therapeutic Implications ◽  
Cellular Effects ◽  
Recent Developments ◽  
And Function ◽  
Messenger Molecule

AbstractCyclic guanosine monophosphate (cGMP) is a unique second messenger molecule formed in different cell types and tissues. cGMP targets a variety of downstream effector molecules and, thus, elicits a very broad variety of cellular effects. Its production is triggered by stimulation of either soluble guanylyl cyclase (sGC) or particulate guanylyl cyclase (pGC); both enzymes exist in different isoforms. cGMP-induced effects are regulated by endogenous receptor ligands such as nitric oxide (NO) and natriuretic peptides (NPs). Depending on the distribution of sGC and pGC and the formation of ligands, this pathway regulates not only the cardiovascular system but also the kidney, lung, liver, and brain function; in addition, the cGMP pathway is involved in the pathogenesis of fibrosis, inflammation, or neurodegeneration and may also play a role in infectious diseases such as malaria. Moreover, new pharmacological approaches are being developed which target sGC- and pGC-dependent pathways for the treatment of various diseases. Therefore, it is of key interest to understand this pathway from scratch, beginning with the molecular basis of cGMP generation, the structure and function of both guanylyl cyclases and cGMP downstream targets; research efforts also focus on the subsequent signaling cascades, their potential crosstalk, and also the translational and, ultimately, the clinical implications of cGMP modulation. This review tries to summarize the contributions to the “9th International cGMP Conference on cGMP Generators, Effectors and Therapeutic Implications” held in Mainz in 2019. Presented data will be discussed and extended also in light of recent landmark findings and ongoing activities in the field of preclinical and clinical cGMP research.

The cGMP system: components and function

2020 ◽  
Vol 401 (4) ◽  
pp. 447-469 ◽  
Author(s):  
Franz Hofmann
Keyword(s):  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Signaling System ◽  
Pde Inhibitors ◽  
Mammalian Tissues ◽  
System Components ◽  
Cgmp Signaling ◽  
Dependent Protein ◽  
Successful Approach ◽  
And Function

AbstractThe cyclic guanosine monophosphate (cGMP) signaling system is one of the most prominent regulators of a variety of physiological and pathophysiological processes in many mammalian and non-mammalian tissues. Targeting this pathway by increasing cGMP levels has been a very successful approach in pharmacology as shown for nitrates, phosphodiesterase (PDE) inhibitors and stimulators of nitric oxide-guanylyl cyclase (NO-GC) and particulate GC (pGC). This is an introductory review to the cGMP signaling system intended to introduce those readers to this system, who do not work in this area. This article does not intend an in-depth review of this system. Signal transduction by cGMP is controlled by the generating enzymes GCs, the degrading enzymes PDEs and the cGMP-regulated enzymes cyclic nucleotide-gated ion channels, cGMP-dependent protein kinases and cGMP-regulated PDEs. Part A gives a very concise introduction to the components. Part B gives a very concise introduction to the functions modulated by cGMP. The article cites many recent reviews for those who want a deeper insight.

Dibenzoquinazoline diones as antihypertensive cyclic guanosine monophosphate phosphodiesterase inhibitors

1987 ◽  
Vol 36 (20) ◽  
pp. 3517-3521 ◽  
Author(s):  
Robert F.G. Booth ◽  
Susan P. Buckham ◽  
David O. Lunt ◽  
Paul W. Manley ◽  
Roderick A. Porter
Keyword(s):  
Phosphodiesterase Inhibitors ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Cyclic Guanosine Monophosphate Phosphodiesterase
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