Thyroxine accelerates the differentiation of granular convoluted tubule cells and the appearance of epidermal growth factor in the submandibular gland of the neonatal mouse

1987 ◽  
Vol 248 (2) ◽  
Author(s):  
J.-G. Chabot ◽  
P. Walker ◽  
G. Pelletier
1984 ◽  
Vol 106 (2) ◽  
pp. 184-187 ◽  
Author(s):  
J. Perheentupa ◽  
J. Lakshmanan ◽  
T. Macaso ◽  
D. A. Fisher

Abstract. The effects of bovine growth hormone (bGH) and triiodothyronine (T3), alone and in combination, were studied on urinary-EGF (U-EGF) in newborn mice. All three treatments significantly augmented the concentration of U-EGF. The effect was far greater for T3 than for bGH. No EGF response was seen in submandibular gland or kidney tissues suggesting that, in newborn animals, these hormones selectively modulate U-EGF.


1990 ◽  
Vol 45 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Eduardo C. Salido ◽  
Jayaraman Lakshmanan ◽  
Larry J. Shapiro ◽  
Delbert A. Fisher ◽  
Luciano Barajas

2002 ◽  
Vol 106 (1-3) ◽  
pp. 105-114 ◽  
Author(s):  
Jesper Thulesen ◽  
Mustafa Vakur Bor ◽  
Stina Thulesen ◽  
Ebba Nexø ◽  
Steen Seier Poulsen ◽  
...  

1985 ◽  
Vol 249 (3) ◽  
pp. R285-R289
Author(s):  
S. Okamoto ◽  
T. Oka

The eyelid opening of pups born to and nursed by normal mice occurred by the 15th day of birth, whereas pregestational sialoadenectomy (removal of submandibular glands) of nursing mice delayed eyelid opening of their pups by as much as 5 days. Parotidectomy, however, had no effect on eyelid opening. Cross-foster nursing experiments indicated that the cause for delayed eyelid opening of pups was to be found in sialoadenectomized mothers, not their pups. Sialoadenectomized mothers had underdeveloped mammary glands that produced approximately 50% less milk than controls, and the amount of epidermal growth factor in their milk was similarly reduced. When epidermal growth factor, a polypeptide produced by the submandibular gland, was injected daily at a dose of 5 micrograms into sialoadenectomized pregnant mice, the eyelid opening of the pups nursed by their mothers occurred normally. These results are discussed with regard to the possible role of the submandibular gland and epidermal growth factor in neonatal eyelid opening.


1990 ◽  
Vol 52 ◽  
pp. 305
Author(s):  
Masanori Kashimata ◽  
Masahiko Hiramatsu ◽  
Makoto Murayama ◽  
Akinao Sato ◽  
Satoshi Yokose ◽  
...  

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