scholarly journals Allelic diversity at the primate major histocompatibility complex DRB6 locus

1992 ◽  
Vol 36 (6) ◽  
Author(s):  
Alfredo Corell ◽  
Pablo Morales ◽  
Pilar Varela ◽  
Estela Paz-Artal ◽  
J.Manuel Martin-Villa ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Allelic Diversity ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Primate Major Histocompatibility Complex

Allelic diversity at the primate major histocompatibility complex DRB6 locus

1992 ◽  
Vol 36 (1) ◽  
pp. 33-38 ◽  
Author(s):  
Alfredo Corell ◽  
Pablo Morales ◽  
Pilar Varela ◽  
Estela Paz-Artal ◽  
J.Manuel Martin-Villa ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Allelic Diversity ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Primate Major Histocompatibility Complex

Phylogeny of primate major histocompatibility complex DRB alleles

1991 ◽  
Vol 31 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Jan Klein ◽  
Masanori Kasahara ◽  
Jutta Gutknecht ◽  
Christian Schönbach
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Histocompatibility Complex ◽  
Primate Major Histocompatibility Complex

Alu elements of the primate major histocompatibility complex

1994 ◽  
Vol 5 (7) ◽  
pp. 405-415 ◽  
Author(s):  
M. Mňuková-Fajdelová ◽  
Y. Satta ◽  
C. O'hUigin ◽  
W. E. Mayer ◽  
F. Figueroa ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility ◽  
Alu Elements ◽  
Histocompatibility Complex ◽  
Primate Major Histocompatibility Complex

scholarly journals Major Histocompatibility complex-DMB allelic diversity in old and new world nonhuman primates: Intraspecies pattern of evolution

2015 ◽  
Vol 1 (8) ◽  
pp. 25 ◽  
Author(s):  
Maria José Recio ◽  
Ester Muniz ◽  
Jose Palacio-Grüber ◽  
Jorge Martinez-Laso ◽  
Eduardo Gomez-Casado ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
New World ◽  
Nonhuman Primates ◽  
Allelic Diversity ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

scholarly journals Bovine Leukocyte Antigen Major Histocompatibility Complex Class II DRB3*2703 and DRB3*1501 Alleles Are Associated with Variation in Levels of Protection against Theileria parva Challenge following Immunization with the Sporozoite p67 Antigen

2004 ◽  
Vol 72 (5) ◽  
pp. 2738-2741 ◽  
Author(s):  
Keith T. Ballingall ◽  
Anthony Luyai ◽  
G. John Rowlands ◽  
Jill Sales ◽  
Anthony J. Musoke ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
Major Histocompatibility Complex Class ◽  
Clinical Signs ◽  
Allelic Diversity ◽  
Class Ii ◽  
Theileria Parva ◽  
Complex Class ◽  
Major Histocompatibility ◽  
Leukocyte Antigen ◽  
Histocompatibility Complex

ABSTRACT Initial laboratory trials of an experimental subunit vaccine against Theileria parva based on the 67-kDa major sporozoite surface antigen revealed a range of responses to challenge. We have analyzed convergence in seven sets of monozygotic twins which suggests that genetic factors may have an influence in determining the degree of protection provided by p67 immunization. In addition, we have examined whether allelic diversity at major histocompatibility complex class II loci influences protection. Analysis of bovine leukocyte antigen DRB3 diversity in 201 animals identified significant associations with vaccine success (DRB3*2703; P = 0.027) and vaccine failure (DRB3*1501; P = 0.013). Furthermore, DRB3*2703 was associated with the likelihood of immunized animals showing little to no clinical signs of disease following challenge. We discuss the acquired and innate immune mechanisms that may be behind the associations described here.

scholarly journals Sexual selection and the evolutionary dynamics of the major histocompatibility complex

2014 ◽  
Vol 281 (1796) ◽  
pp. 20141662 ◽  
Author(s):  
Maciej Jan Ejsmond ◽  
Jacek Radwan ◽  
Anthony B. Wilson
Keyword(s):  
Sexual Selection ◽  
Major Histocompatibility Complex ◽  
Natural Selection ◽  
Evolutionary Dynamics ◽  
Allelic Variation ◽  
Allelic Diversity ◽  
Major Histocompatibility ◽  
Disassortative Mating ◽  
Functional Variants ◽  
Histocompatibility Complex

The genes of the major histocompatibility complex (MHC) are a key component of the adaptive immune system and among the most variable loci in the vertebrate genome. Pathogen-mediated natural selection and MHC-based disassortative mating are both thought to structure MHC polymorphism, but their effects have proven difficult to discriminate in natural systems. Using the first model of MHC dynamics incorporating both survival and reproduction, we demonstrate that natural and sexual selection produce distinctive signatures of MHC allelic diversity with critical implications for understanding host–pathogen dynamics. While natural selection produces the Red Queen dynamics characteristic of host–parasite interactions, disassortative mating stabilizes allele frequencies, damping major fluctuations in dominant alleles and protecting functional variants against drift. This subtle difference generates a complex interaction between MHC allelic diversity and population size. In small populations, the stabilizing effects of sexual selection moderate the effects of drift, whereas pathogen-mediated selection accelerates the loss of functionally important genetic diversity. Natural selection enhances MHC allelic variation in larger populations, with the highest levels of diversity generated by the combined action of pathogen-mediated selection and disassortative mating. MHC-based sexual selection may help to explain how functionally important genetic variation can be maintained in populations of conservation concern.

scholarly journals Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae)

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0254604
Author(s):  
Janet C. Buckner ◽  
Katharine M. Jack ◽  
Amanda D. Melin ◽  
Valérie A. M. Schoof ◽  
Gustavo A. Gutiérrez-Espeleta ◽  
...  
Keyword(s):  
Major Histocompatibility Complex ◽  
High Throughput Sequencing ◽  
Gene Evolution ◽  
Phylogenetic Analyses ◽  
Genome Structure ◽  
Allelic Diversity ◽  
Class Ii ◽  
Experimental Models ◽  
Major Histocompatibility ◽  
Histocompatibility Complex

The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primarily in captive platyrrhine individuals from research colonies. However, investigations of standing MHC variation and evolution in wild populations are essential to understanding its role in immunity, sociality and ecology. Capuchins are a promising model group exhibiting the greatest habitat diversity, widest diet breadth and arguably the most social complexity among platyrrhines, together likely resulting in varied immunological challenges. We use high-throughput sequencing to characterize polymorphism in four Class II DR and DQ exons for the first time in seven capuchin species. We find evidence for at least three copies for DQ genes and at least five for DRB, with possible additional unrecovered diversity. Our data also reveal common genotypes that are inherited across our most widely sampled population, Cebus imitator in Sector Santa Rosa, Costa Rica. Notably, phylogenetic analyses reveal that platyrrhine DQA sequences form a monophyletic group to the exclusion of all Catarrhini sequences examined. This result is inconsistent with the trans-species hypothesis for MHC evolution across infraorders in Primates and provides further evidence for the independent origin of current MHC genetic diversity in Platyrrhini. Identical allele sharing across cebid species, and more rarely genera, however, does underscore the complexity of MHC gene evolution and the need for more comprehensive assessments of allelic diversity and genome structure.

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